Targeting nicotinic acetylcholine receptor to treat smoking-related periodontitis
Summay Tobacco smoking is considered to be one of the major risk factors for periodontitis. Nicotine, the major component in tobacco smoke, has been considered playing an important role in tobacco-related morbidity by acting through the nicotinic acetylcholine receptors (nAChRs) expressed by non-neu...
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| Veröffentlicht in: | Medical hypotheses 2011-02, Vol.76 (2), p.244-245 |
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| creator | Liu, Ying-Feng Ge, Xin Wen, Ling-Ying Wang, Xiao-Jing |
| description | Summay Tobacco smoking is considered to be one of the major risk factors for periodontitis. Nicotine, the major component in tobacco smoke, has been considered playing an important role in tobacco-related morbidity by acting through the nicotinic acetylcholine receptors (nAChRs) expressed by non-neuronal cells. Recently studies found that nAChRs could be expressed on oral gingival and periodontal tissues. We hypothesize that nicotine may act on periodontal tissues directly and specifically through nAChRs to affect periodontitis activity, and that nicotine-induced periodontitis could be prevented by tissue-selective nAChR inhibitors targeting periodontal nAChRs. Thus, periodontal nAChRs may provide to be novel molecular targets to treat smoking-related periodontitis, effectively blocking of periodontal nAChRs may offer an optimistic outlook for the therapy of smoking- related periodontitis. |
| doi_str_mv | 10.1016/j.mehy.2010.10.009 |
| format | Article |
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Nicotine, the major component in tobacco smoke, has been considered playing an important role in tobacco-related morbidity by acting through the nicotinic acetylcholine receptors (nAChRs) expressed by non-neuronal cells. Recently studies found that nAChRs could be expressed on oral gingival and periodontal tissues. We hypothesize that nicotine may act on periodontal tissues directly and specifically through nAChRs to affect periodontitis activity, and that nicotine-induced periodontitis could be prevented by tissue-selective nAChR inhibitors targeting periodontal nAChRs. Thus, periodontal nAChRs may provide to be novel molecular targets to treat smoking-related periodontitis, effectively blocking of periodontal nAChRs may offer an optimistic outlook for the therapy of smoking- related periodontitis.</description><identifier>ISSN: 0306-9877</identifier><identifier>EISSN: 1532-2777</identifier><identifier>DOI: 10.1016/j.mehy.2010.10.009</identifier><identifier>PMID: 21041033</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Animals ; Cell Proliferation ; Gingiva - metabolism ; Humans ; Internal Medicine ; Neurons - metabolism ; Nicotine - chemistry ; Nicotinic Antagonists - pharmacology ; Periodontitis - drug therapy ; Periodontitis - etiology ; Rats ; Receptors, Nicotinic - metabolism ; Smoking - adverse effects</subject><ispartof>Medical hypotheses, 2011-02, Vol.76 (2), p.244-245</ispartof><rights>Elsevier Ltd</rights><rights>2010 Elsevier Ltd</rights><rights>Copyright © 2010 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-ecfaeb11e4226c231de251c2cd2463cfe651405bb856eceb25cda2629ac29d313</citedby><cites>FETCH-LOGICAL-c476t-ecfaeb11e4226c231de251c2cd2463cfe651405bb856eceb25cda2629ac29d313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.mehy.2010.10.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21041033$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Ying-Feng</creatorcontrib><creatorcontrib>Ge, Xin</creatorcontrib><creatorcontrib>Wen, Ling-Ying</creatorcontrib><creatorcontrib>Wang, Xiao-Jing</creatorcontrib><title>Targeting nicotinic acetylcholine receptor to treat smoking-related periodontitis</title><title>Medical hypotheses</title><addtitle>Med Hypotheses</addtitle><description>Summay Tobacco smoking is considered to be one of the major risk factors for periodontitis. Nicotine, the major component in tobacco smoke, has been considered playing an important role in tobacco-related morbidity by acting through the nicotinic acetylcholine receptors (nAChRs) expressed by non-neuronal cells. Recently studies found that nAChRs could be expressed on oral gingival and periodontal tissues. We hypothesize that nicotine may act on periodontal tissues directly and specifically through nAChRs to affect periodontitis activity, and that nicotine-induced periodontitis could be prevented by tissue-selective nAChR inhibitors targeting periodontal nAChRs. Thus, periodontal nAChRs may provide to be novel molecular targets to treat smoking-related periodontitis, effectively blocking of periodontal nAChRs may offer an optimistic outlook for the therapy of smoking- related periodontitis.</description><subject>Animals</subject><subject>Cell Proliferation</subject><subject>Gingiva - metabolism</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Neurons - metabolism</subject><subject>Nicotine - chemistry</subject><subject>Nicotinic Antagonists - pharmacology</subject><subject>Periodontitis - drug therapy</subject><subject>Periodontitis - etiology</subject><subject>Rats</subject><subject>Receptors, Nicotinic - metabolism</subject><subject>Smoking - adverse effects</subject><issn>0306-9877</issn><issn>1532-2777</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9PGzEQxa0KVELaL8AB7Y3TpvZ4_2SlCgkhKJUiIQScLe94kjjsrlPbQcq3x9vQHjhwGmv03tP49xg7E3wmuKh-bGY9rfcz4H8XM86bL2wiSgk51HV9xCZc8ipv5nV9wk5D2PCkKOT8KzsBwQvBpZywhyftVxTtsMoGiy49LGYaKe47XLvODpR5QtpG57PosuhJxyz07iU5ck-djmSyLXnrjBuijTZ8Y8dL3QX6_j6n7Pn25un6Ll_c__p9fbXIsairmBMuNbVCUAFQIUhhCEqBgAaKSuKSqlIUvGzbeVmlA1oo0WiooNEIjZFCTtnFIXfr3Z8dhah6G5C6Tg_kdkHNZV2UJYcmKeGgRO9C8LRUW2977fdKcDWSVBs1klQjyXGXOCXT-Xv8ru3J_Lf8Q5cEPw8CSp98teRVQEsDkrGJWFTG2c_zLz_YsRvh6-6F9hQ2bueHhE8JFUBx9Th2OVYpUosFcJBv-q2bXg</recordid><startdate>20110201</startdate><enddate>20110201</enddate><creator>Liu, Ying-Feng</creator><creator>Ge, Xin</creator><creator>Wen, Ling-Ying</creator><creator>Wang, Xiao-Jing</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110201</creationdate><title>Targeting nicotinic acetylcholine receptor to treat smoking-related periodontitis</title><author>Liu, Ying-Feng ; Ge, Xin ; Wen, Ling-Ying ; Wang, Xiao-Jing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-ecfaeb11e4226c231de251c2cd2463cfe651405bb856eceb25cda2629ac29d313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Cell Proliferation</topic><topic>Gingiva - metabolism</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Neurons - metabolism</topic><topic>Nicotine - chemistry</topic><topic>Nicotinic Antagonists - pharmacology</topic><topic>Periodontitis - drug therapy</topic><topic>Periodontitis - etiology</topic><topic>Rats</topic><topic>Receptors, Nicotinic - metabolism</topic><topic>Smoking - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Ying-Feng</creatorcontrib><creatorcontrib>Ge, Xin</creatorcontrib><creatorcontrib>Wen, Ling-Ying</creatorcontrib><creatorcontrib>Wang, Xiao-Jing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Medical hypotheses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Ying-Feng</au><au>Ge, Xin</au><au>Wen, Ling-Ying</au><au>Wang, Xiao-Jing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Targeting nicotinic acetylcholine receptor to treat smoking-related periodontitis</atitle><jtitle>Medical hypotheses</jtitle><addtitle>Med Hypotheses</addtitle><date>2011-02-01</date><risdate>2011</risdate><volume>76</volume><issue>2</issue><spage>244</spage><epage>245</epage><pages>244-245</pages><issn>0306-9877</issn><eissn>1532-2777</eissn><abstract>Summay Tobacco smoking is considered to be one of the major risk factors for periodontitis. Nicotine, the major component in tobacco smoke, has been considered playing an important role in tobacco-related morbidity by acting through the nicotinic acetylcholine receptors (nAChRs) expressed by non-neuronal cells. Recently studies found that nAChRs could be expressed on oral gingival and periodontal tissues. We hypothesize that nicotine may act on periodontal tissues directly and specifically through nAChRs to affect periodontitis activity, and that nicotine-induced periodontitis could be prevented by tissue-selective nAChR inhibitors targeting periodontal nAChRs. Thus, periodontal nAChRs may provide to be novel molecular targets to treat smoking-related periodontitis, effectively blocking of periodontal nAChRs may offer an optimistic outlook for the therapy of smoking- related periodontitis.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>21041033</pmid><doi>10.1016/j.mehy.2010.10.009</doi><tpages>2</tpages></addata></record> |
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| ispartof | Medical hypotheses, 2011-02, Vol.76 (2), p.244-245 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Cell Proliferation Gingiva - metabolism Humans Internal Medicine Neurons - metabolism Nicotine - chemistry Nicotinic Antagonists - pharmacology Periodontitis - drug therapy Periodontitis - etiology Rats Receptors, Nicotinic - metabolism Smoking - adverse effects |
| title | Targeting nicotinic acetylcholine receptor to treat smoking-related periodontitis |
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