Iso-renin of extrarenal origin: The tissue angiotensinogenase systems

Enzymes, similar to kidney renin, are present in extrarenal tissue of most mammals; they hydrolyze angiotensinogen to form angiotensin I. We suggest that these enzymes be called angiotensinogenases. Angiotensinogenase concentrations in extrarenal tissue can exceed those in the kidney. The enzyme has...

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Veröffentlicht in:	The American journal of medicine 1976-05, Vol.60 (6), p.760-772
Hauptverfasser:	Ganten, Detlev, Schelling, Pierre, Vecsei, Paul, Ganten, Ursula
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Glands - enzymology Angiotensin II - analogs & derivatives Angiotensin II - biosynthesis Angiotensinogen - metabolism Animals Brain - enzymology Cells, Cultured Cerebrospinal Fluid - enzymology Female Humans Kidney Neoplasms - enzymology Mice Rabbits Rats Renin - analysis Renin - biosynthesis Renin - isolation & purification Submandibular Gland - enzymology Uterus - enzymology
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