Circulating suppressor cells in man as a function of age
Concanavalin A (Con A) was used to activate suppressor cells derived from the peripheral blood of human donors. Activated suppressor cells reduced the mitogenic response of autologous peripheral blood lymphocytes (PBLs) more markedly in elderly than in young adults (72.2 ± 5.0 vs 41.8 ± 7.2%, P <...
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| Veröffentlicht in: | Clinical immunology and immunopathology 1978, Vol.9 (1), p.134-141 |
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| container_title | Clinical immunology and immunopathology |
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| creator | Antel, Jack P. Weinrich, Michael Arnason, Barry G.W. |
| description | Concanavalin A (Con A) was used to activate suppressor cells derived from the peripheral blood of human donors. Activated suppressor cells reduced the mitogenic response of autologous peripheral blood lymphocytes (PBLs) more markedly in elderly than in young adults (72.2 ± 5.0 vs 41.8 ± 7.2%,
P < 0.02). The baseline mitogenic response of PBLs from elderly adults was significantly lower than that of PBLs from normal young adults (9497 ± 2609 vs 28,068 ± 3973 cpm,
P < 0.01). A group of young multiple sclerosis patients showed poor mitogenic responsiveness (11,017 ± 2679 cpm) and low suppressor activity (36.0 ± 3.0%) suggesting that suppressor influence need not depend on the activity of responder cells. Unconcentrated supernatants from Con A-activated cells did not suppress the mitogenic response of autologous lymphocytes but did suppress a human lymphoblast cell line (Raji). |
| doi_str_mv | 10.1016/0090-1229(78)90130-7 |
| format | Article |
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P < 0.02). The baseline mitogenic response of PBLs from elderly adults was significantly lower than that of PBLs from normal young adults (9497 ± 2609 vs 28,068 ± 3973 cpm,
P < 0.01). A group of young multiple sclerosis patients showed poor mitogenic responsiveness (11,017 ± 2679 cpm) and low suppressor activity (36.0 ± 3.0%) suggesting that suppressor influence need not depend on the activity of responder cells. Unconcentrated supernatants from Con A-activated cells did not suppress the mitogenic response of autologous lymphocytes but did suppress a human lymphoblast cell line (Raji).</description><identifier>ISSN: 0090-1229</identifier><identifier>EISSN: 1090-2341</identifier><identifier>DOI: 10.1016/0090-1229(78)90130-7</identifier><identifier>PMID: 618406</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Aging ; Cell Line ; Concanavalin A - pharmacology ; Humans ; Immunity, Cellular ; Immunosuppression ; Lymphocyte Activation ; Lymphocytes - immunology ; Time Factors</subject><ispartof>Clinical immunology and immunopathology, 1978, Vol.9 (1), p.134-141</ispartof><rights>1978</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-a9c4efb9d5ca41af635bcae6b04ece3ed21ce894a5e688a493d69637fd17db123</citedby><cites>FETCH-LOGICAL-c356t-a9c4efb9d5ca41af635bcae6b04ece3ed21ce894a5e688a493d69637fd17db123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4021,27921,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/618406$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Antel, Jack P.</creatorcontrib><creatorcontrib>Weinrich, Michael</creatorcontrib><creatorcontrib>Arnason, Barry G.W.</creatorcontrib><title>Circulating suppressor cells in man as a function of age</title><title>Clinical immunology and immunopathology</title><addtitle>Clin Immunol Immunopathol</addtitle><description>Concanavalin A (Con A) was used to activate suppressor cells derived from the peripheral blood of human donors. Activated suppressor cells reduced the mitogenic response of autologous peripheral blood lymphocytes (PBLs) more markedly in elderly than in young adults (72.2 ± 5.0 vs 41.8 ± 7.2%,
P < 0.02). The baseline mitogenic response of PBLs from elderly adults was significantly lower than that of PBLs from normal young adults (9497 ± 2609 vs 28,068 ± 3973 cpm,
P < 0.01). A group of young multiple sclerosis patients showed poor mitogenic responsiveness (11,017 ± 2679 cpm) and low suppressor activity (36.0 ± 3.0%) suggesting that suppressor influence need not depend on the activity of responder cells. Unconcentrated supernatants from Con A-activated cells did not suppress the mitogenic response of autologous lymphocytes but did suppress a human lymphoblast cell line (Raji).</description><subject>Adult</subject><subject>Aged</subject><subject>Aging</subject><subject>Cell Line</subject><subject>Concanavalin A - pharmacology</subject><subject>Humans</subject><subject>Immunity, Cellular</subject><subject>Immunosuppression</subject><subject>Lymphocyte Activation</subject><subject>Lymphocytes - immunology</subject><subject>Time Factors</subject><issn>0090-1229</issn><issn>1090-2341</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kElLxDAUx4O4jaPfYA45iR6qSZPJchFkcIMBL3oOafI6RLqZtILf3tbKHD09eP-F934IrSi5oYSKW0I0yWie6yuprjWhjGTyAC3otM4Zp4dosbecorOUPgghghN5go4FVZyIBVKbEN1Q2T40O5yGrouQUhuxg6pKODS4tg22CVtcDo3rQ9vgtsR2B-foqLRVgou_uUTvjw9vm-ds-_r0srnfZo6tRZ9Z7TiUhfZrZzm1pWDrwlkQBeHggIHPqQOluV2DUMpyzbzQgsnSU-kLmrMlupx7u9h-DpB6U4c0XWcbaIdkFJO5YpqNRj4bXWxTilCaLobaxm9DiZl4mQmGmWAYqcwvLyPH2Oqvfyhq8PvQDGiU72YZxh-_AkSTXIDGgQ8RXG98G_7v_wHONnlY</recordid><startdate>1978</startdate><enddate>1978</enddate><creator>Antel, Jack P.</creator><creator>Weinrich, Michael</creator><creator>Arnason, Barry G.W.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1978</creationdate><title>Circulating suppressor cells in man as a function of age</title><author>Antel, Jack P. ; Weinrich, Michael ; Arnason, Barry G.W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-a9c4efb9d5ca41af635bcae6b04ece3ed21ce894a5e688a493d69637fd17db123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aging</topic><topic>Cell Line</topic><topic>Concanavalin A - pharmacology</topic><topic>Humans</topic><topic>Immunity, Cellular</topic><topic>Immunosuppression</topic><topic>Lymphocyte Activation</topic><topic>Lymphocytes - immunology</topic><topic>Time Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>Antel, Jack P.</creatorcontrib><creatorcontrib>Weinrich, Michael</creatorcontrib><creatorcontrib>Arnason, Barry G.W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical immunology and immunopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Antel, Jack P.</au><au>Weinrich, Michael</au><au>Arnason, Barry G.W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating suppressor cells in man as a function of age</atitle><jtitle>Clinical immunology and immunopathology</jtitle><addtitle>Clin Immunol Immunopathol</addtitle><date>1978</date><risdate>1978</risdate><volume>9</volume><issue>1</issue><spage>134</spage><epage>141</epage><pages>134-141</pages><issn>0090-1229</issn><eissn>1090-2341</eissn><abstract>Concanavalin A (Con A) was used to activate suppressor cells derived from the peripheral blood of human donors. Activated suppressor cells reduced the mitogenic response of autologous peripheral blood lymphocytes (PBLs) more markedly in elderly than in young adults (72.2 ± 5.0 vs 41.8 ± 7.2%,
P < 0.02). The baseline mitogenic response of PBLs from elderly adults was significantly lower than that of PBLs from normal young adults (9497 ± 2609 vs 28,068 ± 3973 cpm,
P < 0.01). A group of young multiple sclerosis patients showed poor mitogenic responsiveness (11,017 ± 2679 cpm) and low suppressor activity (36.0 ± 3.0%) suggesting that suppressor influence need not depend on the activity of responder cells. Unconcentrated supernatants from Con A-activated cells did not suppress the mitogenic response of autologous lymphocytes but did suppress a human lymphoblast cell line (Raji).</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>618406</pmid><doi>10.1016/0090-1229(78)90130-7</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Clinical immunology and immunopathology, 1978, Vol.9 (1), p.134-141 |
| issn | 0090-1229 1090-2341 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83728393 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Aged Aging Cell Line Concanavalin A - pharmacology Humans Immunity, Cellular Immunosuppression Lymphocyte Activation Lymphocytes - immunology Time Factors |
| title | Circulating suppressor cells in man as a function of age |
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