Dihydroergotamine binding to rat brain membranes

3H-dihydroergotamine, which is used clinically to treat orthostatic hypotension and migraine, binds saturably, reversibly and with high affinity (K D = 0.2 nM) to rat brain membranes. The binding is time, temperature and pH dependent and is highest in the hippocampus and the corpus striatum. Seroton...

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Veröffentlicht in:	Life sciences (1973) 1976-12, Vol.19 (12), p.1851-1864
Hauptverfasser:	Closse, Annemarie, Hauser, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Binding, Competitive Brain - ultrastructure Cations, Divalent - pharmacology Dihydroergotamine - metabolism Ergot Alkaloids - metabolism Ergotamines Heart Hydrogen-Ion Concentration Kinetics Male Rats Serotonin - metabolism Stereoisomerism Structure-Activity Relationship Subcellular Fractions - metabolism
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