antitumor and antibacterial activity of the Isodon diterpenoids
Oridonin (1), lasiokaurin (2), enmein (8), and enmein-3-acetate (9) and related compounds (3 and 10, ) all of which have α-methylene cyclopentanone function in their molecule, have been shown to have antitumor activity against Ehrlich ascites carcinoma inoculated into mice. These compounds have also...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1976/09/25, Vol.24(9), pp.2118-2127 |
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| container_title | Chemical & pharmaceutical bulletin |
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| creator | Fujita, E Nagao, Y Kaneko, K Nakazawa, S Kuroda, H |
| description | Oridonin (1), lasiokaurin (2), enmein (8), and enmein-3-acetate (9) and related compounds (3 and 10, ) all of which have α-methylene cyclopentanone function in their molecule, have been shown to have antitumor activity against Ehrlich ascites carcinoma inoculated into mice. These compounds have also indicated specific activity against gram-positive bacteria. On the other hand, oridonin dihydro-derivative (4), compound (5), trichokaurin (6), and dihydroenmein (11) show any activity against neither tumor nor bacteria. Thus, it is concluded that the α-methylene-cyclopentanone system must be an important active center. Biomimetic reactions of oridonin and enmein with several thiols etc. support this conclusion. |
| doi_str_mv | 10.1248/cpb.24.2118 |
| format | Article |
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These compounds have also indicated specific activity against gram-positive bacteria. On the other hand, oridonin dihydro-derivative (4), compound (5), trichokaurin (6), and dihydroenmein (11) show any activity against neither tumor nor bacteria. Thus, it is concluded that the α-methylene-cyclopentanone system must be an important active center. 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Pharm. Bull.</addtitle><date>1976</date><risdate>1976</risdate><volume>24</volume><issue>9</issue><spage>2118</spage><epage>2127</epage><pages>2118-2127</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><abstract>Oridonin (1), lasiokaurin (2), enmein (8), and enmein-3-acetate (9) and related compounds (3 and 10, ) all of which have α-methylene cyclopentanone function in their molecule, have been shown to have antitumor activity against Ehrlich ascites carcinoma inoculated into mice. These compounds have also indicated specific activity against gram-positive bacteria. On the other hand, oridonin dihydro-derivative (4), compound (5), trichokaurin (6), and dihydroenmein (11) show any activity against neither tumor nor bacteria. Thus, it is concluded that the α-methylene-cyclopentanone system must be an important active center. 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| identifier | ISSN: 0009-2363 |
| ispartof | Chemical and Pharmaceutical Bulletin, 1976/09/25, Vol.24(9), pp.2118-2127 |
| issn | 0009-2363 1347-5223 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83661136 |
| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Anti-Bacterial Agents Antineoplastic Agents Bacteria - drug effects Diterpenes - pharmacology Mice plant biochemistry Plant Extracts plant physiology Plants, Medicinal |
| title | antitumor and antibacterial activity of the Isodon diterpenoids |
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