Monoamine oxidase and catechol-O-methyltransferase activities in cultured human skin fibroblasts

Human fibroblasts obtained from normal male children and children with the Lesch-Nyhan syndrome were found to contain both the A and B forms of monoamine oxidase, with the A form predominating. Both forms of monoamine oxidase showed decreased activities in Lesch-Nyhan, as compared to normal cells; w...

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Veröffentlicht in:	Life sciences (1973) 1976-12, Vol.19 (11), p.1705-1710
Hauptverfasser:	Roth, Jerome A., Breakefield, Xandra O., Castiglione, Carmela M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Catechol O-Methyltransferase - metabolism Cells, Cultured Clorgyline - pharmacology Fibroblasts Humans Hypoxanthine Phosphoribosyltransferase - metabolism Lesch-Nyhan Syndrome - enzymology Male Monoamine Oxidase - metabolism Monoamine Oxidase Inhibitors Phenethylamines - metabolism Serotonin - metabolism Skin - enzymology
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