A TRANSMISSIBLE SUBACUTE SPONGIFORM ENCEPHALOPATHY IN A VISITOR TO THE EASTERN HIGHLANDS OF NEW GUINEA
A Caucasian male, clinically ill with a respiratory disease, visited the Eastern Highlands of New Guinea (endemic for kuru in the Fore people) and developed subacute spongiform encephalopathy (Jakob-Creutzfeldt disease) ten weeks later, from which he subsequently died. Brain material was inoculated...
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| Veröffentlicht in: | Brain (London, England : 1878) England : 1878), 1976-12, Vol.99 (4), p.637-658 |
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| container_end_page | 658 |
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| container_issue | 4 |
| container_start_page | 637 |
| container_title | Brain (London, England : 1878) |
| container_volume | 99 |
| creator | GRABOW, JACK D. CAMPBELL, R. JEAN OKAZAKI, HARUO SCHUT, LAWRENCE ZOLLMAN, PAUL E. KURLAND, LEONARD T. |
| description | A Caucasian male, clinically ill with a respiratory disease, visited the Eastern Highlands of New Guinea (endemic for kuru in the Fore people) and developed subacute spongiform encephalopathy (Jakob-Creutzfeldt disease) ten weeks later, from which he subsequently died. Brain material was inoculated intracranially into squirrel monkeys, and several of them developed a spongiform encephalopathy. Monkeys that received control material (normal brain) were normal. Electronmicroscopic features in affected brain tissue are described, and the question of a relationship between Jakob-Creutzfeldt disease and kuru is considered. |
| doi_str_mv | 10.1093/brain/99.4.637 |
| format | Article |
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JEAN ; OKAZAKI, HARUO ; SCHUT, LAWRENCE ; ZOLLMAN, PAUL E. ; KURLAND, LEONARD T.</creator><creatorcontrib>GRABOW, JACK D. ; CAMPBELL, R. JEAN ; OKAZAKI, HARUO ; SCHUT, LAWRENCE ; ZOLLMAN, PAUL E. ; KURLAND, LEONARD T.</creatorcontrib><description>A Caucasian male, clinically ill with a respiratory disease, visited the Eastern Highlands of New Guinea (endemic for kuru in the Fore people) and developed subacute spongiform encephalopathy (Jakob-Creutzfeldt disease) ten weeks later, from which he subsequently died. Brain material was inoculated intracranially into squirrel monkeys, and several of them developed a spongiform encephalopathy. Monkeys that received control material (normal brain) were normal. Electronmicroscopic features in affected brain tissue are described, and the question of a relationship between Jakob-Creutzfeldt disease and kuru is considered.</description><identifier>ISSN: 0006-8950</identifier><identifier>EISSN: 1460-2156</identifier><identifier>DOI: 10.1093/brain/99.4.637</identifier><identifier>PMID: 828865</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Animals ; Brain Diseases - microbiology ; Brain Diseases - physiopathology ; Brain Diseases - transmission ; Cerebral Cortex - pathology ; Creutzfeldt-Jakob Syndrome - microbiology ; Electroencephalography ; Haplorhini ; Humans ; Kuru - microbiology ; Male ; Middle Aged ; New Guinea ; Saimiri ; Slow Virus Diseases - microbiology ; Slow Virus Diseases - physiopathology ; Slow Virus Diseases - transmission</subject><ispartof>Brain (London, England : 1878), 1976-12, Vol.99 (4), p.637-658</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c327t-1eb9c25100b13b4d38f3257f4d6d641e63044458ee0a3dcef735cdaf6c2811d03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/828865$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GRABOW, JACK D.</creatorcontrib><creatorcontrib>CAMPBELL, R. 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Electronmicroscopic features in affected brain tissue are described, and the question of a relationship between Jakob-Creutzfeldt disease and kuru is considered.</description><subject>Animals</subject><subject>Brain Diseases - microbiology</subject><subject>Brain Diseases - physiopathology</subject><subject>Brain Diseases - transmission</subject><subject>Cerebral Cortex - pathology</subject><subject>Creutzfeldt-Jakob Syndrome - microbiology</subject><subject>Electroencephalography</subject><subject>Haplorhini</subject><subject>Humans</subject><subject>Kuru - microbiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>New Guinea</subject><subject>Saimiri</subject><subject>Slow Virus Diseases - microbiology</subject><subject>Slow Virus Diseases - physiopathology</subject><subject>Slow Virus Diseases - transmission</subject><issn>0006-8950</issn><issn>1460-2156</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kDtPwzAUhS3EqzxWJgZPbCl2_IgzmuI2RiGpkhQKi5WHIxVaCnErwb8nUMR0r3S-c4YPgAuMhhiF5LrqysXbdRgO6ZCTYA8MMOXI8zHj-2CAEOKeCBk6BifOvSCEKfH5ETgUvhCcDUArYZHJJL_Xea5vYgXz2Y0czYr-mabJRI_T7B6qZKSmkYzTqSyiJ6gTKOGDznWRZrBIYREpqGReqCyBkZ5EsUxuc5iOYaIe4WSmEyXPwEFbLp09_7unYDZWxSjy4nSiRzL2auIHGw_bKqx9hhGqMKloQ0RLfBa0tOENp9hygiilTFiLStLUtg0Iq5uy5bUvMG4QOQVXu933bv2xtW5jVgtX2-WyfLPrrTOCcMZ8LnpwuAPrbu1cZ1vz3i1WZfdlMDI_Xs2vVxOGhprea1-4_FveVivb_OM7kX3s7eKF29jP_7TsXg0PSMBMNH8287vbOQ-zzDySb-vYerA</recordid><startdate>197612</startdate><enddate>197612</enddate><creator>GRABOW, JACK D.</creator><creator>CAMPBELL, R. JEAN</creator><creator>OKAZAKI, HARUO</creator><creator>SCHUT, LAWRENCE</creator><creator>ZOLLMAN, PAUL E.</creator><creator>KURLAND, LEONARD T.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197612</creationdate><title>A TRANSMISSIBLE SUBACUTE SPONGIFORM ENCEPHALOPATHY IN A VISITOR TO THE EASTERN HIGHLANDS OF NEW GUINEA</title><author>GRABOW, JACK D. ; CAMPBELL, R. JEAN ; OKAZAKI, HARUO ; SCHUT, LAWRENCE ; ZOLLMAN, PAUL E. ; KURLAND, LEONARD T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c327t-1eb9c25100b13b4d38f3257f4d6d641e63044458ee0a3dcef735cdaf6c2811d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>Animals</topic><topic>Brain Diseases - microbiology</topic><topic>Brain Diseases - physiopathology</topic><topic>Brain Diseases - transmission</topic><topic>Cerebral Cortex - pathology</topic><topic>Creutzfeldt-Jakob Syndrome - microbiology</topic><topic>Electroencephalography</topic><topic>Haplorhini</topic><topic>Humans</topic><topic>Kuru - microbiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>New Guinea</topic><topic>Saimiri</topic><topic>Slow Virus Diseases - microbiology</topic><topic>Slow Virus Diseases - physiopathology</topic><topic>Slow Virus Diseases - transmission</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GRABOW, JACK D.</creatorcontrib><creatorcontrib>CAMPBELL, R. JEAN</creatorcontrib><creatorcontrib>OKAZAKI, HARUO</creatorcontrib><creatorcontrib>SCHUT, LAWRENCE</creatorcontrib><creatorcontrib>ZOLLMAN, PAUL E.</creatorcontrib><creatorcontrib>KURLAND, LEONARD T.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain (London, England : 1878)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GRABOW, JACK D.</au><au>CAMPBELL, R. 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Monkeys that received control material (normal brain) were normal. Electronmicroscopic features in affected brain tissue are described, and the question of a relationship between Jakob-Creutzfeldt disease and kuru is considered.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>828865</pmid><doi>10.1093/brain/99.4.637</doi><tpages>22</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-8950 |
| ispartof | Brain (London, England : 1878), 1976-12, Vol.99 (4), p.637-658 |
| issn | 0006-8950 1460-2156 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83655268 |
| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Animals Brain Diseases - microbiology Brain Diseases - physiopathology Brain Diseases - transmission Cerebral Cortex - pathology Creutzfeldt-Jakob Syndrome - microbiology Electroencephalography Haplorhini Humans Kuru - microbiology Male Middle Aged New Guinea Saimiri Slow Virus Diseases - microbiology Slow Virus Diseases - physiopathology Slow Virus Diseases - transmission |
| title | A TRANSMISSIBLE SUBACUTE SPONGIFORM ENCEPHALOPATHY IN A VISITOR TO THE EASTERN HIGHLANDS OF NEW GUINEA |
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