The immune response at the tumor site in lung carcinoma

The local immune response to lung cancer was investigated by histologic and immunologic means. Distinctive patterns of stromal cellular reaction, characteristic for different histologic types of lung carcinoma, were recognized. The amount of cellular infiltration was highest in squamous cell carcino...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cancer 1976-12, Vol.38 (6), p.2296-2309
Hauptverfasser: Ioachim, Harry L., Dorsett, Brent H., Paluch, Edward
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 2309
container_issue 6
container_start_page 2296
container_title Cancer
container_volume 38
creator Ioachim, Harry L.
Dorsett, Brent H.
Paluch, Edward
description The local immune response to lung cancer was investigated by histologic and immunologic means. Distinctive patterns of stromal cellular reaction, characteristic for different histologic types of lung carcinoma, were recognized. The amount of cellular infiltration was highest in squamous cell carcinomas and lowest or nonexistent in oat cell carcinomas. Within the various histologic categories the well‐differentiated tumors appeared to be accompanied by more reactive cells than the poorly differentiated ones; there was no relation between tumor necrosis and cellular infiltration. The plasma cells were distinctly associated with squamous cell carcinomas; their number in the stroma was proportionate to the degree of differentiation and the presence of keratin produced by the tumors. Eluates with a high content of immunoglobulins were recovered from pleural effusions and from solid lung carcinomas by dissociation of antigen‐antibody complexes. These preparations reacted positively in indirect immunofluorescence tests with tissue cultures and with fresh suspensions of lung carcinoma cells, but not with tissue culture cells of most nonpulmonary tumors or with cell suspensions of normal adult and fetal lung. Similarly prepared fractions of noncarcinomatous pleural effusions did not react with lung cancer cells.
doi_str_mv 10.1002/1097-0142(197612)38:6<2296::AID-CNCR2820380617>3.0.CO;2-1
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_83625579</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>83625579</sourcerecordid><originalsourceid>FETCH-LOGICAL-p2307-1c6265e51fbac1c2da25d136948779eb25316db8ba1c542d59e1d6314dc1e7ce3</originalsourceid><addsrcrecordid>eNpdkNtKxDAQhoN4WlffwIteiV50zSTNoasISz0tLC6IgndDmkat9GTTIr69XVYUvQqT_5th5iNkBnQClLJToLEKKUTsGGIlgZ1wPZXnjMVyOp3NL8PkLrlnmlGuqQR1wSd0kizPWAgbZPTTu0lGlFIdiog_7ZI979-GUjHBd8g2aMVBjoh6eHVBXpZ95YLW-aauvAtMF3TDd9eXdRv4vBuIKij66iWwprV5VZdmn2w9m8K7g-93TB6vrx6S23CxvJkns0XYME5VCFYyKZyA59RYsCwzTGTAZRxppWKXDsuAzFKdGrAiYpmIHWSSQ5RZcMo6PiZH67lNW7_3zndY5t66ojCVq3uPmksmhIoH8PAb7NPSZdi0eWnaT1wfOsTZOv7IC_f5m1Jc-caVM1w5w7Vv5BolrnzjoBv_6kaOFJMlDvC_hH8BLw14dw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>83625579</pqid></control><display><type>article</type><title>The immune response at the tumor site in lung carcinoma</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Ioachim, Harry L. ; Dorsett, Brent H. ; Paluch, Edward</creator><creatorcontrib>Ioachim, Harry L. ; Dorsett, Brent H. ; Paluch, Edward</creatorcontrib><description>The local immune response to lung cancer was investigated by histologic and immunologic means. Distinctive patterns of stromal cellular reaction, characteristic for different histologic types of lung carcinoma, were recognized. The amount of cellular infiltration was highest in squamous cell carcinomas and lowest or nonexistent in oat cell carcinomas. Within the various histologic categories the well‐differentiated tumors appeared to be accompanied by more reactive cells than the poorly differentiated ones; there was no relation between tumor necrosis and cellular infiltration. The plasma cells were distinctly associated with squamous cell carcinomas; their number in the stroma was proportionate to the degree of differentiation and the presence of keratin produced by the tumors. Eluates with a high content of immunoglobulins were recovered from pleural effusions and from solid lung carcinomas by dissociation of antigen‐antibody complexes. These preparations reacted positively in indirect immunofluorescence tests with tissue cultures and with fresh suspensions of lung carcinoma cells, but not with tissue culture cells of most nonpulmonary tumors or with cell suspensions of normal adult and fetal lung. Similarly prepared fractions of noncarcinomatous pleural effusions did not react with lung cancer cells.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(197612)38:6&lt;2296::AID-CNCR2820380617&gt;3.0.CO;2-1</identifier><identifier>PMID: 187316</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adenocarcinoma - immunology ; Adenocarcinoma - pathology ; Adenocarcinoma, Bronchiolo-Alveolar - immunology ; Adenocarcinoma, Bronchiolo-Alveolar - pathology ; Antibodies, Neoplasm - isolation &amp; purification ; Antigens, Neoplasm ; Carcinoma - immunology ; Carcinoma - pathology ; Carcinoma, Small Cell - immunology ; Carcinoma, Small Cell - pathology ; Carcinoma, Squamous Cell - immunology ; Carcinoma, Squamous Cell - pathology ; Culture Techniques ; Humans ; Immunity, Cellular ; Immunoglobulins - analysis ; Lung Neoplasms - immunology ; Lung Neoplasms - pathology ; Lymphocytes - immunology ; Plasma Cells - immunology</subject><ispartof>Cancer, 1976-12, Vol.38 (6), p.2296-2309</ispartof><rights>Copyright © 1976 American Cancer Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/187316$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ioachim, Harry L.</creatorcontrib><creatorcontrib>Dorsett, Brent H.</creatorcontrib><creatorcontrib>Paluch, Edward</creatorcontrib><title>The immune response at the tumor site in lung carcinoma</title><title>Cancer</title><addtitle>Cancer</addtitle><description>The local immune response to lung cancer was investigated by histologic and immunologic means. Distinctive patterns of stromal cellular reaction, characteristic for different histologic types of lung carcinoma, were recognized. The amount of cellular infiltration was highest in squamous cell carcinomas and lowest or nonexistent in oat cell carcinomas. Within the various histologic categories the well‐differentiated tumors appeared to be accompanied by more reactive cells than the poorly differentiated ones; there was no relation between tumor necrosis and cellular infiltration. The plasma cells were distinctly associated with squamous cell carcinomas; their number in the stroma was proportionate to the degree of differentiation and the presence of keratin produced by the tumors. Eluates with a high content of immunoglobulins were recovered from pleural effusions and from solid lung carcinomas by dissociation of antigen‐antibody complexes. These preparations reacted positively in indirect immunofluorescence tests with tissue cultures and with fresh suspensions of lung carcinoma cells, but not with tissue culture cells of most nonpulmonary tumors or with cell suspensions of normal adult and fetal lung. Similarly prepared fractions of noncarcinomatous pleural effusions did not react with lung cancer cells.</description><subject>Adenocarcinoma - immunology</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma, Bronchiolo-Alveolar - immunology</subject><subject>Adenocarcinoma, Bronchiolo-Alveolar - pathology</subject><subject>Antibodies, Neoplasm - isolation &amp; purification</subject><subject>Antigens, Neoplasm</subject><subject>Carcinoma - immunology</subject><subject>Carcinoma - pathology</subject><subject>Carcinoma, Small Cell - immunology</subject><subject>Carcinoma, Small Cell - pathology</subject><subject>Carcinoma, Squamous Cell - immunology</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Culture Techniques</subject><subject>Humans</subject><subject>Immunity, Cellular</subject><subject>Immunoglobulins - analysis</subject><subject>Lung Neoplasms - immunology</subject><subject>Lung Neoplasms - pathology</subject><subject>Lymphocytes - immunology</subject><subject>Plasma Cells - immunology</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkNtKxDAQhoN4WlffwIteiV50zSTNoasISz0tLC6IgndDmkat9GTTIr69XVYUvQqT_5th5iNkBnQClLJToLEKKUTsGGIlgZ1wPZXnjMVyOp3NL8PkLrlnmlGuqQR1wSd0kizPWAgbZPTTu0lGlFIdiog_7ZI979-GUjHBd8g2aMVBjoh6eHVBXpZ95YLW-aauvAtMF3TDd9eXdRv4vBuIKij66iWwprV5VZdmn2w9m8K7g-93TB6vrx6S23CxvJkns0XYME5VCFYyKZyA59RYsCwzTGTAZRxppWKXDsuAzFKdGrAiYpmIHWSSQ5RZcMo6PiZH67lNW7_3zndY5t66ojCVq3uPmksmhIoH8PAb7NPSZdi0eWnaT1wfOsTZOv7IC_f5m1Jc-caVM1w5w7Vv5BolrnzjoBv_6kaOFJMlDvC_hH8BLw14dw</recordid><startdate>197612</startdate><enddate>197612</enddate><creator>Ioachim, Harry L.</creator><creator>Dorsett, Brent H.</creator><creator>Paluch, Edward</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>197612</creationdate><title>The immune response at the tumor site in lung carcinoma</title><author>Ioachim, Harry L. ; Dorsett, Brent H. ; Paluch, Edward</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p2307-1c6265e51fbac1c2da25d136948779eb25316db8ba1c542d59e1d6314dc1e7ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>Adenocarcinoma - immunology</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma, Bronchiolo-Alveolar - immunology</topic><topic>Adenocarcinoma, Bronchiolo-Alveolar - pathology</topic><topic>Antibodies, Neoplasm - isolation &amp; purification</topic><topic>Antigens, Neoplasm</topic><topic>Carcinoma - immunology</topic><topic>Carcinoma - pathology</topic><topic>Carcinoma, Small Cell - immunology</topic><topic>Carcinoma, Small Cell - pathology</topic><topic>Carcinoma, Squamous Cell - immunology</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Culture Techniques</topic><topic>Humans</topic><topic>Immunity, Cellular</topic><topic>Immunoglobulins - analysis</topic><topic>Lung Neoplasms - immunology</topic><topic>Lung Neoplasms - pathology</topic><topic>Lymphocytes - immunology</topic><topic>Plasma Cells - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ioachim, Harry L.</creatorcontrib><creatorcontrib>Dorsett, Brent H.</creatorcontrib><creatorcontrib>Paluch, Edward</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ioachim, Harry L.</au><au>Dorsett, Brent H.</au><au>Paluch, Edward</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The immune response at the tumor site in lung carcinoma</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1976-12</date><risdate>1976</risdate><volume>38</volume><issue>6</issue><spage>2296</spage><epage>2309</epage><pages>2296-2309</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><abstract>The local immune response to lung cancer was investigated by histologic and immunologic means. Distinctive patterns of stromal cellular reaction, characteristic for different histologic types of lung carcinoma, were recognized. The amount of cellular infiltration was highest in squamous cell carcinomas and lowest or nonexistent in oat cell carcinomas. Within the various histologic categories the well‐differentiated tumors appeared to be accompanied by more reactive cells than the poorly differentiated ones; there was no relation between tumor necrosis and cellular infiltration. The plasma cells were distinctly associated with squamous cell carcinomas; their number in the stroma was proportionate to the degree of differentiation and the presence of keratin produced by the tumors. Eluates with a high content of immunoglobulins were recovered from pleural effusions and from solid lung carcinomas by dissociation of antigen‐antibody complexes. These preparations reacted positively in indirect immunofluorescence tests with tissue cultures and with fresh suspensions of lung carcinoma cells, but not with tissue culture cells of most nonpulmonary tumors or with cell suspensions of normal adult and fetal lung. Similarly prepared fractions of noncarcinomatous pleural effusions did not react with lung cancer cells.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>187316</pmid><doi>10.1002/1097-0142(197612)38:6&lt;2296::AID-CNCR2820380617&gt;3.0.CO;2-1</doi><tpages>14</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0008-543X
ispartof Cancer, 1976-12, Vol.38 (6), p.2296-2309
issn 0008-543X
1097-0142
language eng
recordid cdi_proquest_miscellaneous_83625579
source MEDLINE; Alma/SFX Local Collection
subjects Adenocarcinoma - immunology
Adenocarcinoma - pathology
Adenocarcinoma, Bronchiolo-Alveolar - immunology
Adenocarcinoma, Bronchiolo-Alveolar - pathology
Antibodies, Neoplasm - isolation & purification
Antigens, Neoplasm
Carcinoma - immunology
Carcinoma - pathology
Carcinoma, Small Cell - immunology
Carcinoma, Small Cell - pathology
Carcinoma, Squamous Cell - immunology
Carcinoma, Squamous Cell - pathology
Culture Techniques
Humans
Immunity, Cellular
Immunoglobulins - analysis
Lung Neoplasms - immunology
Lung Neoplasms - pathology
Lymphocytes - immunology
Plasma Cells - immunology
title The immune response at the tumor site in lung carcinoma
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T20%3A40%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20immune%20response%20at%20the%20tumor%20site%20in%20lung%20carcinoma&rft.jtitle=Cancer&rft.au=Ioachim,%20Harry%20L.&rft.date=1976-12&rft.volume=38&rft.issue=6&rft.spage=2296&rft.epage=2309&rft.pages=2296-2309&rft.issn=0008-543X&rft.eissn=1097-0142&rft_id=info:doi/10.1002/1097-0142(197612)38:6%3C2296::AID-CNCR2820380617%3E3.0.CO;2-1&rft_dat=%3Cproquest_pubme%3E83625579%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=83625579&rft_id=info:pmid/187316&rfr_iscdi=true