Application of Trichloroacetyl Isocyanate to NMR Analysis of Steroids of Pharmaceutical Interest I: Corticosteroids and Chemically Related Compounds

The trichloroacetyl carbamates of 38 corticosteroids and chemically related compounds were prepared, and their NMR spectra in deuterochloroform were obtained. The effects of the introduction of a number of functional groups on the chemical shift of the carbamate proton signals were determined.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 1976-08, Vol.65 (8), p.1214-1217
Hauptverfasser:	Lanouette, Monique, Legault, Donald, Lodge, Bruce A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Adrenal Cortex Hormones - analysis application to NMR analysis Carbamates carbamates of corticosteroids formed by reaction with trichloroacetyl isocyanate Carbamates-formed by reaction of trichloroacetyl isocyanate with corticosteroids Carbamates—formed by reaction of trichloroacetyl isocyanate with corticosteroids, NMR analysis Chemical Phenomena Chemistry Corticosteroids-NMR analysis of carbamates formed by reaction with trichloroacetyl isocyanate Cyanates Hydroxysteroids - analysis Magnetic Resonance Spectroscopy Methods NMR analysis NMR—analysis, carbamates of corticosteroids formed by reaction with trichloroacetyl isocyanate Trichloroacetyl isocyanate-reaction with corticosteroids to form carbamates Trichloroacetyl isocyanate—reaction with corticosteroids to form carbamates, application to NMR analysis
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Beschreibung
Zusammenfassung:	The trichloroacetyl carbamates of 38 corticosteroids and chemically related compounds were prepared, and their NMR spectra in deuterochloroform were obtained. The effects of the introduction of a number of functional groups on the chemical shift of the carbamate proton signals were determined.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600650821