7-(2-AMINOMETHYLPHENYLACETAMIDO)-3-(1-CARBOXYMETHYLTETRAZOL- 5-YLTHIOMETHYL)-3-CEPHEM-4-CARBOXYLIC ACID
The synthesis of 7-(2-aminomethylphenylacetamido)-3-(1-carboxymethyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid (BL-S786) is described and the antimicrobial activities are compared with cefazolin and cefamandole. The compound exhibits broad antimicrobial spectrum, produces high intramuscular...
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| Veröffentlicht in: | Journal of antibiotics 1976, Vol.29(11), pp.1226-1229 |
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| container_end_page | 1229 |
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| container_issue | 11 |
| container_start_page | 1226 |
| container_title | Journal of antibiotics |
| container_volume | 29 |
| creator | GOTTSTEIN, WILLIAM J. KAPLAN, MURRAY A. COOPER, JEAN A. SILVER, VERA H. NACHFOLGER, SOLOMON J. GRANATEK, ALPHONSE P. |
| description | The synthesis of 7-(2-aminomethylphenylacetamido)-3-(1-carboxymethyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid (BL-S786) is described and the antimicrobial activities are compared with cefazolin and cefamandole. The compound exhibits broad antimicrobial spectrum, produces high intramuscular blood levels in mice and demonstrates a high degree of therapeutic efficacy in experimental bacterial infections in rodents. |
| doi_str_mv | 10.7164/antibiotics.29.1226 |
| format | Article |
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The compound exhibits broad antimicrobial spectrum, produces high intramuscular blood levels in mice and demonstrates a high degree of therapeutic efficacy in experimental bacterial infections in rodents.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.29.1226</identifier><identifier>PMID: 993108</identifier><language>eng</language><publisher>Japan: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>Animals ; Bacteria - drug effects ; Bacterial Infections - drug therapy ; Cefazolin - blood ; Cefazolin - pharmacology ; Cephalosporins - blood ; Cephalosporins - pharmacology ; Cephalosporins - therapeutic use ; Chemical Phenomena ; Chemistry ; Mandelic Acids - blood ; Mandelic Acids - pharmacology ; Mice</subject><ispartof>The Journal of Antibiotics, 1976, Vol.29(11), pp.1226-1229</ispartof><rights>Japan Antibiotics Research Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-13a5b59946d03de90a2d4931edec13fafa374fca61be3c87711bb322a1f7b6773</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/993108$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GOTTSTEIN, WILLIAM J.</creatorcontrib><creatorcontrib>KAPLAN, MURRAY A.</creatorcontrib><creatorcontrib>COOPER, JEAN A.</creatorcontrib><creatorcontrib>SILVER, VERA H.</creatorcontrib><creatorcontrib>NACHFOLGER, SOLOMON J.</creatorcontrib><creatorcontrib>GRANATEK, ALPHONSE P.</creatorcontrib><title>7-(2-AMINOMETHYLPHENYLACETAMIDO)-3-(1-CARBOXYMETHYLTETRAZOL- 5-YLTHIOMETHYL)-3-CEPHEM-4-CARBOXYLIC ACID</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>The synthesis of 7-(2-aminomethylphenylacetamido)-3-(1-carboxymethyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid (BL-S786) is described and the antimicrobial activities are compared with cefazolin and cefamandole. The compound exhibits broad antimicrobial spectrum, produces high intramuscular blood levels in mice and demonstrates a high degree of therapeutic efficacy in experimental bacterial infections in rodents.</description><subject>Animals</subject><subject>Bacteria - drug effects</subject><subject>Bacterial Infections - drug therapy</subject><subject>Cefazolin - blood</subject><subject>Cefazolin - pharmacology</subject><subject>Cephalosporins - blood</subject><subject>Cephalosporins - pharmacology</subject><subject>Cephalosporins - therapeutic use</subject><subject>Chemical Phenomena</subject><subject>Chemistry</subject><subject>Mandelic Acids - blood</subject><subject>Mandelic Acids - pharmacology</subject><subject>Mice</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkM1OwzAQhC3EXyk8ARw4oXJw8dppbB9DCDRS2qAqSJSL5SQOBLVNidMDb09KSsVlrfXMfFoNQpdAhhxc506vmjItq6bM7JDKIVDqHqAeCAEYHFceoh4hFLAQlJyiM2s_CWGccXGCjqVkQEQPvXM8oNibhNN4EiTjefQ8DqbzyPODpP18iG8xwwPAvje7j1_nnSUJkpn3Fkf4eoTbbRzuoluvH7SACXb-ElHoX3t--HCOjgq9sOZi9_bRy2OQ-GMcxU-h70U4czhtMDA9SkdSOm5OWG4k0TR32lNNbjJghS40406RaRdSwzLBOUCaMko1FDx1OWd9dNNx13X1tTG2UcvSZmax0CtTbawSzKWMgGiNrDNmdWVtbQq1rsulrr8VELVtV_1rV1Gptu22qasdfpMuTb7PdHW28rSTP22j381e1nVLWZj_SJCu-MXCbm75e2P2oWtlVuwHX_OL2g</recordid><startdate>19760101</startdate><enddate>19760101</enddate><creator>GOTTSTEIN, WILLIAM J.</creator><creator>KAPLAN, MURRAY A.</creator><creator>COOPER, JEAN A.</creator><creator>SILVER, VERA H.</creator><creator>NACHFOLGER, SOLOMON J.</creator><creator>GRANATEK, ALPHONSE P.</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19760101</creationdate><title>7-(2-AMINOMETHYLPHENYLACETAMIDO)-3-(1-CARBOXYMETHYLTETRAZOL- 5-YLTHIOMETHYL)-3-CEPHEM-4-CARBOXYLIC ACID</title><author>GOTTSTEIN, WILLIAM J. ; KAPLAN, MURRAY A. ; COOPER, JEAN A. ; SILVER, VERA H. ; NACHFOLGER, SOLOMON J. ; GRANATEK, ALPHONSE P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-13a5b59946d03de90a2d4931edec13fafa374fca61be3c87711bb322a1f7b6773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>Animals</topic><topic>Bacteria - drug effects</topic><topic>Bacterial Infections - drug therapy</topic><topic>Cefazolin - blood</topic><topic>Cefazolin - pharmacology</topic><topic>Cephalosporins - blood</topic><topic>Cephalosporins - pharmacology</topic><topic>Cephalosporins - therapeutic use</topic><topic>Chemical Phenomena</topic><topic>Chemistry</topic><topic>Mandelic Acids - blood</topic><topic>Mandelic Acids - pharmacology</topic><topic>Mice</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GOTTSTEIN, WILLIAM J.</creatorcontrib><creatorcontrib>KAPLAN, MURRAY A.</creatorcontrib><creatorcontrib>COOPER, JEAN A.</creatorcontrib><creatorcontrib>SILVER, VERA H.</creatorcontrib><creatorcontrib>NACHFOLGER, SOLOMON J.</creatorcontrib><creatorcontrib>GRANATEK, ALPHONSE P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GOTTSTEIN, WILLIAM J.</au><au>KAPLAN, MURRAY A.</au><au>COOPER, JEAN A.</au><au>SILVER, VERA H.</au><au>NACHFOLGER, SOLOMON J.</au><au>GRANATEK, ALPHONSE P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>7-(2-AMINOMETHYLPHENYLACETAMIDO)-3-(1-CARBOXYMETHYLTETRAZOL- 5-YLTHIOMETHYL)-3-CEPHEM-4-CARBOXYLIC ACID</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>1976-01-01</date><risdate>1976</risdate><volume>29</volume><issue>11</issue><spage>1226</spage><epage>1229</epage><pages>1226-1229</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><abstract>The synthesis of 7-(2-aminomethylphenylacetamido)-3-(1-carboxymethyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid (BL-S786) is described and the antimicrobial activities are compared with cefazolin and cefamandole. The compound exhibits broad antimicrobial spectrum, produces high intramuscular blood levels in mice and demonstrates a high degree of therapeutic efficacy in experimental bacterial infections in rodents.</abstract><cop>Japan</cop><pub>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</pub><pmid>993108</pmid><doi>10.7164/antibiotics.29.1226</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1976, Vol.29(11), pp.1226-1229 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83623018 |
| source | J-STAGE Free; MEDLINE |
| subjects | Animals Bacteria - drug effects Bacterial Infections - drug therapy Cefazolin - blood Cefazolin - pharmacology Cephalosporins - blood Cephalosporins - pharmacology Cephalosporins - therapeutic use Chemical Phenomena Chemistry Mandelic Acids - blood Mandelic Acids - pharmacology Mice |
| title | 7-(2-AMINOMETHYLPHENYLACETAMIDO)-3-(1-CARBOXYMETHYLTETRAZOL- 5-YLTHIOMETHYL)-3-CEPHEM-4-CARBOXYLIC ACID |
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