Neutralizing Activity of Fragments Obtained by Papain Digestion of Viral Antibody
When pure by Ouchterlony and immunoelectrophoretic analyses, 3.5 S Fractions I and II from anti-poliovirus γ-globulin and anti-WEE virus γ-globulin neutralized their respective viruses in the metabolic inhibition test, while 3.5 S crystalline Fractions III with trace contamination of Fraction II gav...
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| Veröffentlicht in: | The Journal of immunology (1950) 1964-08, Vol.93 (2), p.283-292 |
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| container_title | The Journal of immunology (1950) |
| container_volume | 93 |
| creator | Cremer, Natalie E Riggs, John L Fujimoto, Frances Y Hagens, Shirley J Ota, Margaret I Lennette, Edwin H |
| description | When pure by Ouchterlony and immunoelectrophoretic analyses, 3.5 S Fractions I and II from anti-poliovirus γ-globulin and anti-WEE virus γ-globulin neutralized their respective viruses in the metabolic inhibition test, while 3.5 S crystalline Fractions III with trace contamination of Fraction II gave minimal (with poliovirus) or no neutralization (WEE virus).
Pure, 3.5 S Fractions I and II from anti-WEE virus γ-globulin did not give significant neutralization of WEE virus in the mouse, while 3.5 S Fraction III with trace contamination of Fraction II gave significant neutralization (NI ≧ 2). |
| doi_str_mv | 10.4049/jimmunol.93.2.283 |
| format | Article |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Antibodies Antibodies, Viral Encephalitis Viruses gamma-Globulins Immune Sera Immunoelectrophoresis Mice Neutralization Tests Old Medline Papain Pharmacology Poliovirus Precipitin Tests Rabbits |
| title | Neutralizing Activity of Fragments Obtained by Papain Digestion of Viral Antibody |
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