Neutralizing Activity of Fragments Obtained by Papain Digestion of Viral Antibody

When pure by Ouchterlony and immunoelectrophoretic analyses, 3.5 S Fractions I and II from anti-poliovirus γ-globulin and anti-WEE virus γ-globulin neutralized their respective viruses in the metabolic inhibition test, while 3.5 S crystalline Fractions III with trace contamination of Fraction II gav...

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Veröffentlicht in:	The Journal of immunology (1950) 1964-08, Vol.93 (2), p.283-292
Hauptverfasser:	Cremer, Natalie E, Riggs, John L, Fujimoto, Frances Y, Hagens, Shirley J, Ota, Margaret I, Lennette, Edwin H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Viral Encephalitis Viruses gamma-Globulins Immune Sera Immunoelectrophoresis Mice Neutralization Tests Old Medline Papain Pharmacology Poliovirus Precipitin Tests Rabbits
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Beschreibung
Zusammenfassung:	When pure by Ouchterlony and immunoelectrophoretic analyses, 3.5 S Fractions I and II from anti-poliovirus γ-globulin and anti-WEE virus γ-globulin neutralized their respective viruses in the metabolic inhibition test, while 3.5 S crystalline Fractions III with trace contamination of Fraction II gave minimal (with poliovirus) or no neutralization (WEE virus). Pure, 3.5 S Fractions I and II from anti-WEE virus γ-globulin did not give significant neutralization of WEE virus in the mouse, while 3.5 S Fraction III with trace contamination of Fraction II gave significant neutralization (NI ≧ 2).
ISSN:	0022-1767 1550-6606
DOI:	10.4049/jimmunol.93.2.283