A comparison of the acute and chronic effects of four antidepressant drugs on the turnover of serotonin, dopamine and noradrenaline in the rat brain
The acute effects of imipramine, Org GB 94 and iprindol and the chronic effects of imipramine, desipramine, iprindol and Org GB 94 were studied on the turnover of dopamine, noradrenaline and serotonin in the whole rat brain. The effects of these drugs on amine turnover was assessed from the incorpor...
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| Veröffentlicht in: | Biochemical pharmacology 1976-09, Vol.25 (17), p.1939-1942 |
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| container_end_page | 1942 |
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| container_issue | 17 |
| container_start_page | 1939 |
| container_title | Biochemical pharmacology |
| container_volume | 25 |
| creator | Leonard, B.E. Kafoe, W.F. |
| description | The acute effects of imipramine, Org GB 94 and iprindol and the chronic effects of imipramine, desipramine, iprindol and Org GB 94 were studied on the turnover of dopamine, noradrenaline and serotonin in the whole rat brain. The effects of these drugs on amine turnover was assessed from the incorporation of tritiated tyrosine and tryptophan into the amines. Following acute administration, imipramine significantly reduced the turnover of serotonin whereas Org GB 94 increased that of noradrenaline. After chronic administration, imipramine and desipramine reduced the turnover of serotonin and dopamine, iprindol had no significant effect on brain amine turnover whereas Org GB 94 increased the turnover of noradrenaline. The effect of Org GB 94 on noradrenaline turnover was more marked after intraperitoneal than after oral administration. |
| doi_str_mv | 10.1016/0006-2952(76)90046-0 |
| format | Article |
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The effects of these drugs on amine turnover was assessed from the incorporation of tritiated tyrosine and tryptophan into the amines. Following acute administration, imipramine significantly reduced the turnover of serotonin whereas Org GB 94 increased that of noradrenaline. After chronic administration, imipramine and desipramine reduced the turnover of serotonin and dopamine, iprindol had no significant effect on brain amine turnover whereas Org GB 94 increased the turnover of noradrenaline. The effect of Org GB 94 on noradrenaline turnover was more marked after intraperitoneal than after oral administration.</description><identifier>ISSN: 0006-2952</identifier><identifier>EISSN: 1873-2968</identifier><identifier>DOI: 10.1016/0006-2952(76)90046-0</identifier><identifier>PMID: 985530</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Animals ; Antidepressive Agents - pharmacology ; Brain - drug effects ; Brain - metabolism ; Dopamine - metabolism ; Imipramine - pharmacology ; Iprindole - pharmacology ; Male ; Mianserin - metabolism ; Norepinephrine - metabolism ; Rats ; Serotonin - metabolism ; Time Factors ; Tyrosine - metabolism</subject><ispartof>Biochemical pharmacology, 1976-09, Vol.25 (17), p.1939-1942</ispartof><rights>1976</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c271t-ab32d9981ab6c081e380f9faf113925b7d48e957c557ac4f05ff3165fded57683</citedby><cites>FETCH-LOGICAL-c271t-ab32d9981ab6c081e380f9faf113925b7d48e957c557ac4f05ff3165fded57683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-2952(76)90046-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/985530$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leonard, B.E.</creatorcontrib><creatorcontrib>Kafoe, W.F.</creatorcontrib><title>A comparison of the acute and chronic effects of four antidepressant drugs on the turnover of serotonin, dopamine and noradrenaline in the rat brain</title><title>Biochemical pharmacology</title><addtitle>Biochem Pharmacol</addtitle><description>The acute effects of imipramine, Org GB 94 and iprindol and the chronic effects of imipramine, desipramine, iprindol and Org GB 94 were studied on the turnover of dopamine, noradrenaline and serotonin in the whole rat brain. The effects of these drugs on amine turnover was assessed from the incorporation of tritiated tyrosine and tryptophan into the amines. Following acute administration, imipramine significantly reduced the turnover of serotonin whereas Org GB 94 increased that of noradrenaline. After chronic administration, imipramine and desipramine reduced the turnover of serotonin and dopamine, iprindol had no significant effect on brain amine turnover whereas Org GB 94 increased the turnover of noradrenaline. The effect of Org GB 94 on noradrenaline turnover was more marked after intraperitoneal than after oral administration.</description><subject>Animals</subject><subject>Antidepressive Agents - pharmacology</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Dopamine - metabolism</subject><subject>Imipramine - pharmacology</subject><subject>Iprindole - pharmacology</subject><subject>Male</subject><subject>Mianserin - metabolism</subject><subject>Norepinephrine - metabolism</subject><subject>Rats</subject><subject>Serotonin - metabolism</subject><subject>Time Factors</subject><subject>Tyrosine - metabolism</subject><issn>0006-2952</issn><issn>1873-2968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uctu1TAQtRCvS-EPuvAKgUTATq4de1OpqnhJldjA2nLsMTW6scPYqcR_8ME4TdUlG49nzkOaM4Scc_aeMy4_MMZk12vRvxnlW83YUXbsETlwNQ5tLNVjcnigPCcvSvm1tUryZ-SpVkIM7ED-XlKX58ViLDnRHGi9AWrdWtubPHU3mFN0FEIAV8tGCHnFhtXoYUEopX2px_VnA9Oduq6Y8i3gRi6AuTaH9I76vNg5pt03ZbQeIdnTNom7EG2lE9qYXpInwZ4KvLqvZ-THp4_fr750198-f726vO5cP_La2WnovdaK20k6pjgMigUdbOB80L2YRn9UoMXohBitOwYmQhi4FMGDF6NUwxl5vfsumH-vUKqZY3FwOtkEeS1GDZK1mHQjHneiw1wKQjALxtniH8OZ2W5htmTNFrQZpbm7hWFNdn7vv04z-AfRHn6DL3YY2o63EdAUFyE58BFb2sbn-H__f4Bxmuo</recordid><startdate>19760901</startdate><enddate>19760901</enddate><creator>Leonard, B.E.</creator><creator>Kafoe, W.F.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19760901</creationdate><title>A comparison of the acute and chronic effects of four antidepressant drugs on the turnover of serotonin, dopamine and noradrenaline in the rat brain</title><author>Leonard, B.E. ; Kafoe, W.F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c271t-ab32d9981ab6c081e380f9faf113925b7d48e957c557ac4f05ff3165fded57683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>Animals</topic><topic>Antidepressive Agents - pharmacology</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Dopamine - metabolism</topic><topic>Imipramine - pharmacology</topic><topic>Iprindole - pharmacology</topic><topic>Male</topic><topic>Mianserin - metabolism</topic><topic>Norepinephrine - metabolism</topic><topic>Rats</topic><topic>Serotonin - metabolism</topic><topic>Time Factors</topic><topic>Tyrosine - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leonard, B.E.</creatorcontrib><creatorcontrib>Kafoe, W.F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leonard, B.E.</au><au>Kafoe, W.F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A comparison of the acute and chronic effects of four antidepressant drugs on the turnover of serotonin, dopamine and noradrenaline in the rat brain</atitle><jtitle>Biochemical pharmacology</jtitle><addtitle>Biochem Pharmacol</addtitle><date>1976-09-01</date><risdate>1976</risdate><volume>25</volume><issue>17</issue><spage>1939</spage><epage>1942</epage><pages>1939-1942</pages><issn>0006-2952</issn><eissn>1873-2968</eissn><abstract>The acute effects of imipramine, Org GB 94 and iprindol and the chronic effects of imipramine, desipramine, iprindol and Org GB 94 were studied on the turnover of dopamine, noradrenaline and serotonin in the whole rat brain. The effects of these drugs on amine turnover was assessed from the incorporation of tritiated tyrosine and tryptophan into the amines. Following acute administration, imipramine significantly reduced the turnover of serotonin whereas Org GB 94 increased that of noradrenaline. After chronic administration, imipramine and desipramine reduced the turnover of serotonin and dopamine, iprindol had no significant effect on brain amine turnover whereas Org GB 94 increased the turnover of noradrenaline. The effect of Org GB 94 on noradrenaline turnover was more marked after intraperitoneal than after oral administration.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>985530</pmid><doi>10.1016/0006-2952(76)90046-0</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-2952 |
| ispartof | Biochemical pharmacology, 1976-09, Vol.25 (17), p.1939-1942 |
| issn | 0006-2952 1873-2968 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antidepressive Agents - pharmacology Brain - drug effects Brain - metabolism Dopamine - metabolism Imipramine - pharmacology Iprindole - pharmacology Male Mianserin - metabolism Norepinephrine - metabolism Rats Serotonin - metabolism Time Factors Tyrosine - metabolism |
| title | A comparison of the acute and chronic effects of four antidepressant drugs on the turnover of serotonin, dopamine and noradrenaline in the rat brain |
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