Enhanced Resistance of Mice to Infection with Langat (TP21) Virus Following Pre-treatment with Sindbis or Semliki Forest Virus
The Rayne Institute, St Thomas' Hospital, London, SE1 and * Microbiological Research Establishment, Porton Down, nr. Salisbury, Wilts., U.K. Significant protection to heterologous i.c. challenge with the flavovirus Langat occurred after a single i.c. injection of avirulent strains of the alpha...
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| Veröffentlicht in: | Journal of general virology 1976-12, Vol.33 (3), p.381-388 |
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| container_title | Journal of general virology |
| container_volume | 33 |
| creator | Oaten, Susan W Webb, H. E Bowen, E. T. W |
| description | The Rayne Institute, St Thomas' Hospital, London, SE1 and
* Microbiological Research Establishment, Porton Down, nr. Salisbury, Wilts., U.K.
Significant protection to heterologous i.c. challenge with the flavovirus Langat occurred after a single i.c. injection of avirulent strains of the alpha viruses Semliki Forest or Sindbis given 1 day to 5 weeks before challenge. Some protection also occurred after an i.p. infection with these viruses. We consider that the protection afforded by the alpha viruses is due to interference with the multiplication of Langat virus and is related to the maximum level of brain infectivity reached in the alpha virus infection.
Received 7 April 1976;
accepted 16 June 1976. |
| doi_str_mv | 10.1099/0022-1317-33-3-381 |
| format | Article |
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* Microbiological Research Establishment, Porton Down, nr. Salisbury, Wilts., U.K.
Significant protection to heterologous i.c. challenge with the flavovirus Langat occurred after a single i.c. injection of avirulent strains of the alpha viruses Semliki Forest or Sindbis given 1 day to 5 weeks before challenge. Some protection also occurred after an i.p. infection with these viruses. We consider that the protection afforded by the alpha viruses is due to interference with the multiplication of Langat virus and is related to the maximum level of brain infectivity reached in the alpha virus infection.
Received 7 April 1976;
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* Microbiological Research Establishment, Porton Down, nr. Salisbury, Wilts., U.K.
Significant protection to heterologous i.c. challenge with the flavovirus Langat occurred after a single i.c. injection of avirulent strains of the alpha viruses Semliki Forest or Sindbis given 1 day to 5 weeks before challenge. Some protection also occurred after an i.p. infection with these viruses. We consider that the protection afforded by the alpha viruses is due to interference with the multiplication of Langat virus and is related to the maximum level of brain infectivity reached in the alpha virus infection.
Received 7 April 1976;
accepted 16 June 1976.</description><subject>Animals</subject><subject>Antibodies, Viral - analysis</subject><subject>Arbovirus Infections - immunology</subject><subject>Arboviruses - immunology</subject><subject>Cross Reactions</subject><subject>Encephalitis Viruses, Tick-Borne - growth & development</subject><subject>Encephalitis Viruses, Tick-Borne - immunology</subject><subject>Encephalitis Viruses, Tick-Borne - pathogenicity</subject><subject>Female</subject><subject>Hemagglutination, Viral</subject><subject>Interferons - metabolism</subject><subject>Male</subject><subject>Mice</subject><subject>Neutralization Tests</subject><subject>Semliki forest virus - immunology</subject><subject>Sindbis Virus - immunology</subject><subject>Viral Interference</subject><issn>0022-1317</issn><issn>1465-2099</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFUEtv1DAQtipoWVr-AOrBJx6HgMdOss4RVS1UWkRFS6-WY0923SZ2sb2suPDb8ZKqaA4z0vfSfIS8BvYBWNd9ZIzzCgQsKyGqMhIOyALqtql4gZ-RxRPhBXmZ0h1jUNfN8ogcglwuoVuQP-d-o71BS79jcinvbxoG-tWVnQO99AOa7IKnO5c3dKX9Wmf67uaKw3t66-I20YswjmHn_JpeRaxyRJ0n9HkWXDtve5doiPQap9Hdu8KPmPIsPiHPBz0mfPW4j8mPi_Obsy_V6tvny7NPq8pwzqDiTddhNzDJ2vKQBhh60wreyB6kldY2jUVjuOWd4VrXNavZALa2sgXkg5DimLyZfR9i-Lkt8WpyyeA4ao9hm5QULRNNVxcin4kmhpQiDuohuknH3wqY2neu9pWqfaVKCFVGQhGdPrpv-wntf8m_kgv8doY3br3ZuYhqjX5yJaF3Qf1y8cnoL_Yxids</recordid><startdate>19761201</startdate><enddate>19761201</enddate><creator>Oaten, Susan W</creator><creator>Webb, H. E</creator><creator>Bowen, E. T. W</creator><general>Soc General Microbiol</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19761201</creationdate><title>Enhanced Resistance of Mice to Infection with Langat (TP21) Virus Following Pre-treatment with Sindbis or Semliki Forest Virus</title><author>Oaten, Susan W ; Webb, H. E ; Bowen, E. T. W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2201-2599e9f0806022a11fbc63258b18d8dd55decc2d29c2aa44040f1d4d861e2f383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>Animals</topic><topic>Antibodies, Viral - analysis</topic><topic>Arbovirus Infections - immunology</topic><topic>Arboviruses - immunology</topic><topic>Cross Reactions</topic><topic>Encephalitis Viruses, Tick-Borne - growth & development</topic><topic>Encephalitis Viruses, Tick-Borne - immunology</topic><topic>Encephalitis Viruses, Tick-Borne - pathogenicity</topic><topic>Female</topic><topic>Hemagglutination, Viral</topic><topic>Interferons - metabolism</topic><topic>Male</topic><topic>Mice</topic><topic>Neutralization Tests</topic><topic>Semliki forest virus - immunology</topic><topic>Sindbis Virus - immunology</topic><topic>Viral Interference</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oaten, Susan W</creatorcontrib><creatorcontrib>Webb, H. E</creatorcontrib><creatorcontrib>Bowen, E. T. W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of general virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oaten, Susan W</au><au>Webb, H. E</au><au>Bowen, E. T. W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhanced Resistance of Mice to Infection with Langat (TP21) Virus Following Pre-treatment with Sindbis or Semliki Forest Virus</atitle><jtitle>Journal of general virology</jtitle><addtitle>J Gen Virol</addtitle><date>1976-12-01</date><risdate>1976</risdate><volume>33</volume><issue>3</issue><spage>381</spage><epage>388</epage><pages>381-388</pages><issn>0022-1317</issn><eissn>1465-2099</eissn><abstract>The Rayne Institute, St Thomas' Hospital, London, SE1 and
* Microbiological Research Establishment, Porton Down, nr. Salisbury, Wilts., U.K.
Significant protection to heterologous i.c. challenge with the flavovirus Langat occurred after a single i.c. injection of avirulent strains of the alpha viruses Semliki Forest or Sindbis given 1 day to 5 weeks before challenge. Some protection also occurred after an i.p. infection with these viruses. We consider that the protection afforded by the alpha viruses is due to interference with the multiplication of Langat virus and is related to the maximum level of brain infectivity reached in the alpha virus infection.
Received 7 April 1976;
accepted 16 June 1976.</abstract><cop>England</cop><pub>Soc General Microbiol</pub><pmid>187719</pmid><doi>10.1099/0022-1317-33-3-381</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1317 |
| ispartof | Journal of general virology, 1976-12, Vol.33 (3), p.381-388 |
| issn | 0022-1317 1465-2099 |
| language | eng |
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| source | MEDLINE; Microbiology Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Antibodies, Viral - analysis Arbovirus Infections - immunology Arboviruses - immunology Cross Reactions Encephalitis Viruses, Tick-Borne - growth & development Encephalitis Viruses, Tick-Borne - immunology Encephalitis Viruses, Tick-Borne - pathogenicity Female Hemagglutination, Viral Interferons - metabolism Male Mice Neutralization Tests Semliki forest virus - immunology Sindbis Virus - immunology Viral Interference |
| title | Enhanced Resistance of Mice to Infection with Langat (TP21) Virus Following Pre-treatment with Sindbis or Semliki Forest Virus |
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