A mathematical model in immunoregulation where the spleen has a pivotal role
A simple mathematical model is introduced to investigate collaborative interactions between thymus-derived T and bursal-influenced B lymphocytes in the presence of specific antigen, intravenously presented. Such encounters are assumed to lead to humoral antibody response, and antigen interacting to...
Gespeichert in:
| Veröffentlicht in: | Journal of theoretical biology 1976-09, Vol.61 (2), p.363-376 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 376 |
|---|---|
| container_issue | 2 |
| container_start_page | 363 |
| container_title | Journal of theoretical biology |
| container_volume | 61 |
| creator | Wayne Streilein, J. Read, Campbell B. |
| description | A simple mathematical model is introduced to investigate collaborative interactions between thymus-derived T and bursal-influenced B lymphocytes in the presence of specific antigen, intravenously presented. Such encounters are assumed to lead to humoral antibody response, and antigen interacting to produce effector T cells in the absence of B cells is assumed to produce cell mediated immunity. The model is used further to consider (i) the resultant distribution of effector T cells, (ii) the effect of splenectomy on collaborative T-B cell interactions, and (iii) recent data relating to portal cirrhosis, sickle cell anemia, malignant lymphomas, and diseases involving an impaired thymic function.
It is concluded that for soluble antigen, such T-B cell encounters normally predominate in the spleen, as compared with the lymph nodes. Developing principles of immunoregulation may be applied to the theoretical basis of the model. |
| doi_str_mv | 10.1016/0022-5193(76)90024-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_83595843</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0022519376900242</els_id><sourcerecordid>83595843</sourcerecordid><originalsourceid>FETCH-LOGICAL-c357t-204d72aaddd0e405b23ba3741071e881143f5aebbfcb0c7730b86269bcd261753</originalsourceid><addsrcrecordid>eNp9kE9r3DAQxUVJSTdpv0EKOoX04HT0z7IvgbCkaWChl_YsZGm2q2BbG8ne0G8f7W4IOfUyw_Dem2F-hFwwuGbA6u8AnFeKteJK19_aMsmKfyALBq2qGiXZCVm8WT6Rs5wfAaCVoj4lpwyaWoJekNUtHey0wVKCsz0doseehpGGYZjHmPDv3BcpjvR5gwlpsdK87RFHurGZWroNuziVYIo9fiYf17bP-OW1n5M_P-5-L39Wq1_3D8vbVeWE0lPFQXrNrfXeA0pQHRedFVoy0AybhjEp1spi161dB05rAV1T87rtnOc100qck8vj3m2KTzPmyQwhO-x7O2Kcs2mEalUjRTHKo9GlmHPCtdmmMNj0zzAwe4hmT8jsCRldmwNEw0vs6-v-uRvQvwsdqBX95qhjeXIXMJnsAo4OfUjoJuNj-P-BF3AAgDo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>83595843</pqid></control><display><type>article</type><title>A mathematical model in immunoregulation where the spleen has a pivotal role</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Wayne Streilein, J. ; Read, Campbell B.</creator><creatorcontrib>Wayne Streilein, J. ; Read, Campbell B.</creatorcontrib><description>A simple mathematical model is introduced to investigate collaborative interactions between thymus-derived T and bursal-influenced B lymphocytes in the presence of specific antigen, intravenously presented. Such encounters are assumed to lead to humoral antibody response, and antigen interacting to produce effector T cells in the absence of B cells is assumed to produce cell mediated immunity. The model is used further to consider (i) the resultant distribution of effector T cells, (ii) the effect of splenectomy on collaborative T-B cell interactions, and (iii) recent data relating to portal cirrhosis, sickle cell anemia, malignant lymphomas, and diseases involving an impaired thymic function.
It is concluded that for soluble antigen, such T-B cell encounters normally predominate in the spleen, as compared with the lymph nodes. Developing principles of immunoregulation may be applied to the theoretical basis of the model.</description><identifier>ISSN: 0022-5193</identifier><identifier>EISSN: 1095-8541</identifier><identifier>DOI: 10.1016/0022-5193(76)90024-2</identifier><identifier>PMID: 1086407</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Antibody Formation ; B-Lymphocytes - immunology ; Humans ; Immunity, Cellular ; Lymph Nodes - immunology ; Lymphocyte Depletion ; Lymphoma - immunology ; Models, Biological ; Rats ; Spleen - immunology ; T-Lymphocytes - immunology ; Time Factors</subject><ispartof>Journal of theoretical biology, 1976-09, Vol.61 (2), p.363-376</ispartof><rights>1976</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-204d72aaddd0e405b23ba3741071e881143f5aebbfcb0c7730b86269bcd261753</citedby><cites>FETCH-LOGICAL-c357t-204d72aaddd0e405b23ba3741071e881143f5aebbfcb0c7730b86269bcd261753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0022-5193(76)90024-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1086407$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wayne Streilein, J.</creatorcontrib><creatorcontrib>Read, Campbell B.</creatorcontrib><title>A mathematical model in immunoregulation where the spleen has a pivotal role</title><title>Journal of theoretical biology</title><addtitle>J Theor Biol</addtitle><description>A simple mathematical model is introduced to investigate collaborative interactions between thymus-derived T and bursal-influenced B lymphocytes in the presence of specific antigen, intravenously presented. Such encounters are assumed to lead to humoral antibody response, and antigen interacting to produce effector T cells in the absence of B cells is assumed to produce cell mediated immunity. The model is used further to consider (i) the resultant distribution of effector T cells, (ii) the effect of splenectomy on collaborative T-B cell interactions, and (iii) recent data relating to portal cirrhosis, sickle cell anemia, malignant lymphomas, and diseases involving an impaired thymic function.
It is concluded that for soluble antigen, such T-B cell encounters normally predominate in the spleen, as compared with the lymph nodes. Developing principles of immunoregulation may be applied to the theoretical basis of the model.</description><subject>Animals</subject><subject>Antibody Formation</subject><subject>B-Lymphocytes - immunology</subject><subject>Humans</subject><subject>Immunity, Cellular</subject><subject>Lymph Nodes - immunology</subject><subject>Lymphocyte Depletion</subject><subject>Lymphoma - immunology</subject><subject>Models, Biological</subject><subject>Rats</subject><subject>Spleen - immunology</subject><subject>T-Lymphocytes - immunology</subject><subject>Time Factors</subject><issn>0022-5193</issn><issn>1095-8541</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9r3DAQxUVJSTdpv0EKOoX04HT0z7IvgbCkaWChl_YsZGm2q2BbG8ne0G8f7W4IOfUyw_Dem2F-hFwwuGbA6u8AnFeKteJK19_aMsmKfyALBq2qGiXZCVm8WT6Rs5wfAaCVoj4lpwyaWoJekNUtHey0wVKCsz0doseehpGGYZjHmPDv3BcpjvR5gwlpsdK87RFHurGZWroNuziVYIo9fiYf17bP-OW1n5M_P-5-L39Wq1_3D8vbVeWE0lPFQXrNrfXeA0pQHRedFVoy0AybhjEp1spi161dB05rAV1T87rtnOc100qck8vj3m2KTzPmyQwhO-x7O2Kcs2mEalUjRTHKo9GlmHPCtdmmMNj0zzAwe4hmT8jsCRldmwNEw0vs6-v-uRvQvwsdqBX95qhjeXIXMJnsAo4OfUjoJuNj-P-BF3AAgDo</recordid><startdate>19760921</startdate><enddate>19760921</enddate><creator>Wayne Streilein, J.</creator><creator>Read, Campbell B.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19760921</creationdate><title>A mathematical model in immunoregulation where the spleen has a pivotal role</title><author>Wayne Streilein, J. ; Read, Campbell B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-204d72aaddd0e405b23ba3741071e881143f5aebbfcb0c7730b86269bcd261753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>Animals</topic><topic>Antibody Formation</topic><topic>B-Lymphocytes - immunology</topic><topic>Humans</topic><topic>Immunity, Cellular</topic><topic>Lymph Nodes - immunology</topic><topic>Lymphocyte Depletion</topic><topic>Lymphoma - immunology</topic><topic>Models, Biological</topic><topic>Rats</topic><topic>Spleen - immunology</topic><topic>T-Lymphocytes - immunology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wayne Streilein, J.</creatorcontrib><creatorcontrib>Read, Campbell B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of theoretical biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wayne Streilein, J.</au><au>Read, Campbell B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A mathematical model in immunoregulation where the spleen has a pivotal role</atitle><jtitle>Journal of theoretical biology</jtitle><addtitle>J Theor Biol</addtitle><date>1976-09-21</date><risdate>1976</risdate><volume>61</volume><issue>2</issue><spage>363</spage><epage>376</epage><pages>363-376</pages><issn>0022-5193</issn><eissn>1095-8541</eissn><abstract>A simple mathematical model is introduced to investigate collaborative interactions between thymus-derived T and bursal-influenced B lymphocytes in the presence of specific antigen, intravenously presented. Such encounters are assumed to lead to humoral antibody response, and antigen interacting to produce effector T cells in the absence of B cells is assumed to produce cell mediated immunity. The model is used further to consider (i) the resultant distribution of effector T cells, (ii) the effect of splenectomy on collaborative T-B cell interactions, and (iii) recent data relating to portal cirrhosis, sickle cell anemia, malignant lymphomas, and diseases involving an impaired thymic function.
It is concluded that for soluble antigen, such T-B cell encounters normally predominate in the spleen, as compared with the lymph nodes. Developing principles of immunoregulation may be applied to the theoretical basis of the model.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>1086407</pmid><doi>10.1016/0022-5193(76)90024-2</doi><tpages>14</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-5193 |
| ispartof | Journal of theoretical biology, 1976-09, Vol.61 (2), p.363-376 |
| issn | 0022-5193 1095-8541 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83595843 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Antibody Formation B-Lymphocytes - immunology Humans Immunity, Cellular Lymph Nodes - immunology Lymphocyte Depletion Lymphoma - immunology Models, Biological Rats Spleen - immunology T-Lymphocytes - immunology Time Factors |
| title | A mathematical model in immunoregulation where the spleen has a pivotal role |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T19%3A30%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20mathematical%20model%20in%20immunoregulation%20where%20the%20spleen%20has%20a%20pivotal%20role&rft.jtitle=Journal%20of%20theoretical%20biology&rft.au=Wayne%20Streilein,%20J.&rft.date=1976-09-21&rft.volume=61&rft.issue=2&rft.spage=363&rft.epage=376&rft.pages=363-376&rft.issn=0022-5193&rft.eissn=1095-8541&rft_id=info:doi/10.1016/0022-5193(76)90024-2&rft_dat=%3Cproquest_cross%3E83595843%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=83595843&rft_id=info:pmid/1086407&rft_els_id=0022519376900242&rfr_iscdi=true |