Quinazolines and 1,4-benzodiazepines. 75. 7-Hydroxyaminobenzodiazepines and derivatives

7-Nitro-substituted benzodiazepines were reduced with stannous chloride in a buffered system to the corresponding 7-hydroxyamino derivatives. These compounds were alkylated, acylated, and converted to nitroso and azoxy derivatives. The rearrangement of a hydroxyamine to an aminophenol and its oxidat...

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Veröffentlicht in:	Journal of medicinal chemistry 1976-12, Vol.19 (12), p.1378-1381
Hauptverfasser:	Walser, Armin, Zenchoff, Gladys, Fryer, R. Ian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzodiazepines - chemical synthesis Benzodiazepines - metabolism Benzodiazepines - pharmacology Central Nervous System - drug effects Depression, Chemical Mice Pentylenetetrazole - antagonists & inhibitors Structure-Activity Relationship
Online-Zugang:	Volltext
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