Heparin and the removal of triglyceride from the blood stream
This article reviews all the known facts about the mechanism of action of the postheparin lipemia-clearing factor, also termed lipoprotein lipase, in triglyceride lipolysis. This enzyme is normally present in tissues, probably in the capillary walls, and is frequently demonstrable in the plasma. Hep...
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| Veröffentlicht in: | The American journal of cardiology 1964-07, Vol.14 (1), p.8-17 |
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| container_title | The American journal of cardiology |
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| creator | Engelberg, Hyman |
| description | This article reviews all the known facts about the mechanism of action of the postheparin lipemia-clearing factor, also termed lipoprotein lipase, in triglyceride lipolysis. This enzyme is normally present in tissues, probably in the capillary walls, and is frequently demonstrable in the plasma. Heparin is probably a component of the enzyme, functioning as a prosthetic group.
The available evidence on the physiologic pathways involved in the removal of triglyceride from the bloodstream is discussed. The facts indicate that the reticuloendothelial system does not remove chylomicra. Chylomicra probably enter the liver, but the evidence suggests that this organ does not effect a net removal of triglyceride but probably converts it to lipoproteins. The author believes that the heparinactivated lipolytic enzyme, lipoprotein lipase, is the major pathway for the removal of alimentary and endogenous triglycerides from the blood. |
| doi_str_mv | 10.1016/0002-9149(64)90098-0 |
| format | Article |
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The available evidence on the physiologic pathways involved in the removal of triglyceride from the bloodstream is discussed. The facts indicate that the reticuloendothelial system does not remove chylomicra. Chylomicra probably enter the liver, but the evidence suggests that this organ does not effect a net removal of triglyceride but probably converts it to lipoproteins. The author believes that the heparinactivated lipolytic enzyme, lipoprotein lipase, is the major pathway for the removal of alimentary and endogenous triglycerides from the blood.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/0002-9149(64)90098-0</identifier><identifier>PMID: 14176898</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Enzyme Inhibitors ; Glycerides ; Heparin ; Humans ; Lipids - blood ; Lipoprotein Lipase ; Liver - physiology ; Mononuclear Phagocyte System ; Old Medline ; Pharmacology ; Physiology ; Triglycerides</subject><ispartof>The American journal of cardiology, 1964-07, Vol.14 (1), p.8-17</ispartof><rights>1964</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c275t-f5fba5a063794672e96c2432c835b2b853742ab0d3bb7e47e044a558adcfb4633</citedby><cites>FETCH-LOGICAL-c275t-f5fba5a063794672e96c2432c835b2b853742ab0d3bb7e47e044a558adcfb4633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0002914964900980$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14176898$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Engelberg, Hyman</creatorcontrib><title>Heparin and the removal of triglyceride from the blood stream</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>This article reviews all the known facts about the mechanism of action of the postheparin lipemia-clearing factor, also termed lipoprotein lipase, in triglyceride lipolysis. This enzyme is normally present in tissues, probably in the capillary walls, and is frequently demonstrable in the plasma. Heparin is probably a component of the enzyme, functioning as a prosthetic group.
The available evidence on the physiologic pathways involved in the removal of triglyceride from the bloodstream is discussed. The facts indicate that the reticuloendothelial system does not remove chylomicra. Chylomicra probably enter the liver, but the evidence suggests that this organ does not effect a net removal of triglyceride but probably converts it to lipoproteins. The author believes that the heparinactivated lipolytic enzyme, lipoprotein lipase, is the major pathway for the removal of alimentary and endogenous triglycerides from the blood.</description><subject>Enzyme Inhibitors</subject><subject>Glycerides</subject><subject>Heparin</subject><subject>Humans</subject><subject>Lipids - blood</subject><subject>Lipoprotein Lipase</subject><subject>Liver - physiology</subject><subject>Mononuclear Phagocyte System</subject><subject>Old Medline</subject><subject>Pharmacology</subject><subject>Physiology</subject><subject>Triglycerides</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1964</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMo7rr6D0R6Ej1Uk-arOSjIoq6w4EXPIUmnGmmbNeku7L-3-4HePA0Dz_sO8yB0TvANwUTcYoyLXBGmrgS7VhirMscHaExKqXKiCD1E419khE5S-hpWQrg4RiPCiBSlKsfobgYLE32Xma7K-k_IIrRhZZos1Fkf_UezdhB9BVkdQ7sFbBNClaU-gmlP0VFtmgRn-zlB70-Pb9NZPn99fpk-zHNXSN7nNa-t4QYLKhUTsgAlXMFo4UrKbWFLTiUrjMUVtVYCk4AZM5yXpnK1ZYLSCbrc9S5i-F5C6nXrk4OmMR2EZdJDj1RKsgFkO9DFkFKEWi-ib01ca4L1RpveONEbJ1owvdWm8RC72PcvbQvVX2jvaQDudwAMX648RJ2ch85B5SO4XlfB_3_hB0Gheww</recordid><startdate>196407</startdate><enddate>196407</enddate><creator>Engelberg, Hyman</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196407</creationdate><title>Heparin and the removal of triglyceride from the blood stream</title><author>Engelberg, Hyman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c275t-f5fba5a063794672e96c2432c835b2b853742ab0d3bb7e47e044a558adcfb4633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1964</creationdate><topic>Enzyme Inhibitors</topic><topic>Glycerides</topic><topic>Heparin</topic><topic>Humans</topic><topic>Lipids - blood</topic><topic>Lipoprotein Lipase</topic><topic>Liver - physiology</topic><topic>Mononuclear Phagocyte System</topic><topic>Old Medline</topic><topic>Pharmacology</topic><topic>Physiology</topic><topic>Triglycerides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Engelberg, Hyman</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Engelberg, Hyman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heparin and the removal of triglyceride from the blood stream</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>1964-07</date><risdate>1964</risdate><volume>14</volume><issue>1</issue><spage>8</spage><epage>17</epage><pages>8-17</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><abstract>This article reviews all the known facts about the mechanism of action of the postheparin lipemia-clearing factor, also termed lipoprotein lipase, in triglyceride lipolysis. This enzyme is normally present in tissues, probably in the capillary walls, and is frequently demonstrable in the plasma. Heparin is probably a component of the enzyme, functioning as a prosthetic group.
The available evidence on the physiologic pathways involved in the removal of triglyceride from the bloodstream is discussed. The facts indicate that the reticuloendothelial system does not remove chylomicra. Chylomicra probably enter the liver, but the evidence suggests that this organ does not effect a net removal of triglyceride but probably converts it to lipoproteins. The author believes that the heparinactivated lipolytic enzyme, lipoprotein lipase, is the major pathway for the removal of alimentary and endogenous triglycerides from the blood.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>14176898</pmid><doi>10.1016/0002-9149(64)90098-0</doi><tpages>10</tpages></addata></record> |
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| ispartof | The American journal of cardiology, 1964-07, Vol.14 (1), p.8-17 |
| issn | 0002-9149 1879-1913 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Enzyme Inhibitors Glycerides Heparin Humans Lipids - blood Lipoprotein Lipase Liver - physiology Mononuclear Phagocyte System Old Medline Pharmacology Physiology Triglycerides |
| title | Heparin and the removal of triglyceride from the blood stream |
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