The quantitation of plasma phytanic acid by mass fragmentography

Plasma phytanic acid has been quantitated by mass fragmentography after its successive reduction and derivatization to the corresponding t-butyldimethylsilyl ether. The latter was estimated by selective ion monitoring of its characteristic (M-57) ion (M/z 355). The technique has the advantage of bei...

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Veröffentlicht in:Clinica chimica acta 1976-11, Vol.72 (3), p.319-325
Hauptverfasser: Phillipou, G., Poulos, A.
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description Plasma phytanic acid has been quantitated by mass fragmentography after its successive reduction and derivatization to the corresponding t-butyldimethylsilyl ether. The latter was estimated by selective ion monitoring of its characteristic (M-57) ion (M/z 355). The technique has the advantage of being more rapid, specific and sensitive than existing methods, permitting the determination of phytanic acid at levels > 5 μg/ml plasma.
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source MEDLINE; Elsevier ScienceDirect Journals
subjects Chromatography, Gas - methods
Eicosanoic Acids - blood
Gas Chromatography-Mass Spectrometry - methods
Humans
Microchemistry
Phytanic Acid - blood
title The quantitation of plasma phytanic acid by mass fragmentography
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