A modified leukocyte nitroblue tetrazolium test in acute bacterial infection
The increased ability to leukocytes to reduce nitroblue tetrazolium (NBT) has been used to detect the presence of systemic bacterial infection. This test has been utilized to evaluate infections and leukocyte dysfunction in children, but has not been extensively applied to traumatized patients or in...
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| Veröffentlicht in: | American journal of clinical pathology 1976-11, Vol.66 (5), p.905-910 |
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| container_end_page | 910 |
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| container_issue | 5 |
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| container_title | American journal of clinical pathology |
| container_volume | 66 |
| creator | Miller, R M Garbus, J Schwartz, A R DuPont, H L Levine, M M Clyde, D F Hornick, R B |
| description | The increased ability to leukocytes to reduce nitroblue tetrazolium (NBT) has been used to detect the presence of systemic bacterial infection. This test has been utilized to evaluate infections and leukocyte dysfunction in children, but has not been extensively applied to traumatized patients or infected volunteers. Moreover, the technic as originally described presented methodologic difficulties. In this study of 889 such patients, a modified NBT test provided excellent differentiation of 63 systemic bacterial infections (NBT score greater than or equal to 10%) from non-infectious fevers, local enteric diseases, and certain viral and plasmodial infections (NBT score less than or equal to 9%). Splenectomy was associated with a transient false-positive score and clinical typhoid fever with a false-negative response |
| doi_str_mv | 10.1093/ajcp/66.5.905 |
| format | Article |
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This test has been utilized to evaluate infections and leukocyte dysfunction in children, but has not been extensively applied to traumatized patients or infected volunteers. Moreover, the technic as originally described presented methodologic difficulties. In this study of 889 such patients, a modified NBT test provided excellent differentiation of 63 systemic bacterial infections (NBT score greater than or equal to 10%) from non-infectious fevers, local enteric diseases, and certain viral and plasmodial infections (NBT score less than or equal to 9%). Splenectomy was associated with a transient false-positive score and clinical typhoid fever with a false-negative response</description><identifier>ISSN: 0002-9173</identifier><identifier>EISSN: 1943-7722</identifier><identifier>DOI: 10.1093/ajcp/66.5.905</identifier><identifier>PMID: 983998</identifier><language>eng</language><publisher>England</publisher><subject>Acute Disease ; Bacterial Infections - diagnosis ; Bacterial Infections - etiology ; False Positive Reactions ; Fever - diagnosis ; Humans ; Leukocytes - drug effects ; Malaria - diagnosis ; Nitroblue Tetrazolium ; Postoperative Complications - diagnosis ; Sepsis - diagnosis ; Splenectomy ; Tetrazolium Salts ; Virus Diseases - diagnosis ; Wounds and Injuries - complications</subject><ispartof>American journal of clinical pathology, 1976-11, Vol.66 (5), p.905-910</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c287t-43041a9b6ff2e762983ad84d520ddf829e6f6c95335f015a6e359b5d992be1613</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/983998$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miller, R M</creatorcontrib><creatorcontrib>Garbus, J</creatorcontrib><creatorcontrib>Schwartz, A R</creatorcontrib><creatorcontrib>DuPont, H L</creatorcontrib><creatorcontrib>Levine, M M</creatorcontrib><creatorcontrib>Clyde, D F</creatorcontrib><creatorcontrib>Hornick, R B</creatorcontrib><title>A modified leukocyte nitroblue tetrazolium test in acute bacterial infection</title><title>American journal of clinical pathology</title><addtitle>Am J Clin Pathol</addtitle><description>The increased ability to leukocytes to reduce nitroblue tetrazolium (NBT) has been used to detect the presence of systemic bacterial infection. This test has been utilized to evaluate infections and leukocyte dysfunction in children, but has not been extensively applied to traumatized patients or infected volunteers. Moreover, the technic as originally described presented methodologic difficulties. In this study of 889 such patients, a modified NBT test provided excellent differentiation of 63 systemic bacterial infections (NBT score greater than or equal to 10%) from non-infectious fevers, local enteric diseases, and certain viral and plasmodial infections (NBT score less than or equal to 9%). Splenectomy was associated with a transient false-positive score and clinical typhoid fever with a false-negative response</description><subject>Acute Disease</subject><subject>Bacterial Infections - diagnosis</subject><subject>Bacterial Infections - etiology</subject><subject>False Positive Reactions</subject><subject>Fever - diagnosis</subject><subject>Humans</subject><subject>Leukocytes - drug effects</subject><subject>Malaria - diagnosis</subject><subject>Nitroblue Tetrazolium</subject><subject>Postoperative Complications - diagnosis</subject><subject>Sepsis - diagnosis</subject><subject>Splenectomy</subject><subject>Tetrazolium Salts</subject><subject>Virus Diseases - diagnosis</subject><subject>Wounds and Injuries - complications</subject><issn>0002-9173</issn><issn>1943-7722</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kDtPwzAURi3EqxRGNoZMbGn9iJ14rBAvqRILzJZjX0suSV1sZyi_HletmO7V1dGn7x6E7gleECzZUm_MbinEgi8k5mdoRmTD6ral9BzNMMa0lqRl1-gmpQ3GhHa4uUKXsmNSdjO0XlVjsN55sNUA03cw-wzV1ucY-mGCKkOO-jcMfhrLnnLlt5U2U2F6bTJEr4dycmCyD9tbdOH0kODuNOfo6-X58-mtXn-8vj-t1rWhXZvrhuGGaNkL5yi0gpYu2naN5RRb6zoqQThhJGeMO0y4FsC47LmVkvZABGFz9HjM3cXwM5VWavTJwDDoLYQpqY5x0bXl6zmqj6CJIaUITu2iH3XcK4LVQZ46yFNCKK6KvMI_nIKnfgT7Tx9tsT-AC2tm</recordid><startdate>197611</startdate><enddate>197611</enddate><creator>Miller, R M</creator><creator>Garbus, J</creator><creator>Schwartz, A R</creator><creator>DuPont, H L</creator><creator>Levine, M M</creator><creator>Clyde, D F</creator><creator>Hornick, R B</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197611</creationdate><title>A modified leukocyte nitroblue tetrazolium test in acute bacterial infection</title><author>Miller, R M ; Garbus, J ; Schwartz, A R ; DuPont, H L ; Levine, M M ; Clyde, D F ; Hornick, R B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c287t-43041a9b6ff2e762983ad84d520ddf829e6f6c95335f015a6e359b5d992be1613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>Acute Disease</topic><topic>Bacterial Infections - diagnosis</topic><topic>Bacterial Infections - etiology</topic><topic>False Positive Reactions</topic><topic>Fever - diagnosis</topic><topic>Humans</topic><topic>Leukocytes - drug effects</topic><topic>Malaria - diagnosis</topic><topic>Nitroblue Tetrazolium</topic><topic>Postoperative Complications - diagnosis</topic><topic>Sepsis - diagnosis</topic><topic>Splenectomy</topic><topic>Tetrazolium Salts</topic><topic>Virus Diseases - diagnosis</topic><topic>Wounds and Injuries - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miller, R M</creatorcontrib><creatorcontrib>Garbus, J</creatorcontrib><creatorcontrib>Schwartz, A R</creatorcontrib><creatorcontrib>DuPont, H L</creatorcontrib><creatorcontrib>Levine, M M</creatorcontrib><creatorcontrib>Clyde, D F</creatorcontrib><creatorcontrib>Hornick, R B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miller, R M</au><au>Garbus, J</au><au>Schwartz, A R</au><au>DuPont, H L</au><au>Levine, M M</au><au>Clyde, D F</au><au>Hornick, R B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A modified leukocyte nitroblue tetrazolium test in acute bacterial infection</atitle><jtitle>American journal of clinical pathology</jtitle><addtitle>Am J Clin Pathol</addtitle><date>1976-11</date><risdate>1976</risdate><volume>66</volume><issue>5</issue><spage>905</spage><epage>910</epage><pages>905-910</pages><issn>0002-9173</issn><eissn>1943-7722</eissn><abstract>The increased ability to leukocytes to reduce nitroblue tetrazolium (NBT) has been used to detect the presence of systemic bacterial infection. This test has been utilized to evaluate infections and leukocyte dysfunction in children, but has not been extensively applied to traumatized patients or infected volunteers. Moreover, the technic as originally described presented methodologic difficulties. In this study of 889 such patients, a modified NBT test provided excellent differentiation of 63 systemic bacterial infections (NBT score greater than or equal to 10%) from non-infectious fevers, local enteric diseases, and certain viral and plasmodial infections (NBT score less than or equal to 9%). Splenectomy was associated with a transient false-positive score and clinical typhoid fever with a false-negative response</abstract><cop>England</cop><pmid>983998</pmid><doi>10.1093/ajcp/66.5.905</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9173 |
| ispartof | American journal of clinical pathology, 1976-11, Vol.66 (5), p.905-910 |
| issn | 0002-9173 1943-7722 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Acute Disease Bacterial Infections - diagnosis Bacterial Infections - etiology False Positive Reactions Fever - diagnosis Humans Leukocytes - drug effects Malaria - diagnosis Nitroblue Tetrazolium Postoperative Complications - diagnosis Sepsis - diagnosis Splenectomy Tetrazolium Salts Virus Diseases - diagnosis Wounds and Injuries - complications |
| title | A modified leukocyte nitroblue tetrazolium test in acute bacterial infection |
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