STUDIES ON JUVENIMICIN, A NEW ANTIBIOTIC. II: ISOLATION, CHEMICAL CHARACTERIZATION AND STRUCTURES
A series of new macrolide antibiotics was isolated from the culture filtrate of Micromonospora chalcea var. izumensis. The fat-soluble basic complex consisted of eight components which were named juvenimicin A1-A4 and B1-B4. Juvenimicin A3 was found to be identical with rosamicin and the structures...
Gespeichert in:
| Veröffentlicht in: | Journal of antibiotics 1976, Vol.29(11), pp.1171-1181 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1181 |
|---|---|
| container_issue | 11 |
| container_start_page | 1171 |
| container_title | Journal of antibiotics |
| container_volume | 29 |
| creator | KISHI, TOYOKAZU HARADA, SETSUO YAMANA, HIDEO MIYAKE, AKIRA |
| description | A series of new macrolide antibiotics was isolated from the culture filtrate of Micromonospora chalcea var. izumensis. The fat-soluble basic complex consisted of eight components which were named juvenimicin A1-A4 and B1-B4. Juvenimicin A3 was found to be identical with rosamicin and the structures of four of the other components (JVM A2, A4, B1 and B3) have been elucidated. Juvenimicin A2 has a methyl group at position 6 instead of the formyl-methyl group of juvenimicin A3. Juvenimicin A4, B1 and B3 possess a hydroxyethyl group at position 6. Juvenimicin A4 and B1 differ from each other in the nature of the chromophore. Juvenimicin B3 differs from juvenimicin B1 in that a hydroxymethyl group is present at position 14 in the former. |
| doi_str_mv | 10.7164/antibiotics.29.1171 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_83559940</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>83559940</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3961-d2d7300230551049f850ba0aa8b61cc073a23dfc273573fec2cfd516565acb03</originalsourceid><addsrcrecordid>eNpNkD1PwzAYhC3EVyn8AhgyMTXBH3FsjyUEMCrp0BRGy3EcCGqbEqcD_55Eqaou7zvc3XPSAXCLYMBQFD7oTVvlVd1WxgVYBAgxdAJGiHPkozASp2AEIUY-5xhegivnfiAkjDB-Ac6FIAiGIzBZZMsnmSy8eeq9LT-SVL7LWKYTb-qlyac3TTP5KOeZjANPymtwVuqVszf7PwbZc5LFr_5s_iLj6cw3RETIL3DBSNdMIKVdiSg5hbmGWvM8QsZARjQmRWkwI5SR0hpsyoKiiEZUmxySMbgfsNum_t1Z16p15YxdrfTG1junOKFUiLA3ksFomtq5xpZq21Rr3fwpBFW_kDpaSGGh-oW61N0ev8vXtjhkhkk6OR3kH9fqL3uQddNRVvYYiUTEB-z-9vyD0XzrRtkN-Qc1sXqo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>83559940</pqid></control><display><type>article</type><title>STUDIES ON JUVENIMICIN, A NEW ANTIBIOTIC. II: ISOLATION, CHEMICAL CHARACTERIZATION AND STRUCTURES</title><source>J-STAGE Free</source><source>MEDLINE</source><creator>KISHI, TOYOKAZU ; HARADA, SETSUO ; YAMANA, HIDEO ; MIYAKE, AKIRA</creator><creatorcontrib>KISHI, TOYOKAZU ; HARADA, SETSUO ; YAMANA, HIDEO ; MIYAKE, AKIRA</creatorcontrib><description>A series of new macrolide antibiotics was isolated from the culture filtrate of Micromonospora chalcea var. izumensis. The fat-soluble basic complex consisted of eight components which were named juvenimicin A1-A4 and B1-B4. Juvenimicin A3 was found to be identical with rosamicin and the structures of four of the other components (JVM A2, A4, B1 and B3) have been elucidated. Juvenimicin A2 has a methyl group at position 6 instead of the formyl-methyl group of juvenimicin A3. Juvenimicin A4, B1 and B3 possess a hydroxyethyl group at position 6. Juvenimicin A4 and B1 differ from each other in the nature of the chromophore. Juvenimicin B3 differs from juvenimicin B1 in that a hydroxymethyl group is present at position 14 in the former.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.29.1171</identifier><identifier>PMID: 993104</identifier><language>eng</language><publisher>Japan: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>Animals ; Anti-Bacterial Agents - analysis ; Anti-Bacterial Agents - isolation & purification ; Anti-Bacterial Agents - pharmacology ; Bacteria - drug effects ; Chemical Phenomena ; Chemistry ; Mice ; Staphylococcal Infections - prevention & control ; Staphylococcus aureus</subject><ispartof>The Journal of Antibiotics, 1976, Vol.29(11), pp.1171-1181</ispartof><rights>Japan Antibiotics Research Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3961-d2d7300230551049f850ba0aa8b61cc073a23dfc273573fec2cfd516565acb03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/993104$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KISHI, TOYOKAZU</creatorcontrib><creatorcontrib>HARADA, SETSUO</creatorcontrib><creatorcontrib>YAMANA, HIDEO</creatorcontrib><creatorcontrib>MIYAKE, AKIRA</creatorcontrib><title>STUDIES ON JUVENIMICIN, A NEW ANTIBIOTIC. II: ISOLATION, CHEMICAL CHARACTERIZATION AND STRUCTURES</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>A series of new macrolide antibiotics was isolated from the culture filtrate of Micromonospora chalcea var. izumensis. The fat-soluble basic complex consisted of eight components which were named juvenimicin A1-A4 and B1-B4. Juvenimicin A3 was found to be identical with rosamicin and the structures of four of the other components (JVM A2, A4, B1 and B3) have been elucidated. Juvenimicin A2 has a methyl group at position 6 instead of the formyl-methyl group of juvenimicin A3. Juvenimicin A4, B1 and B3 possess a hydroxyethyl group at position 6. Juvenimicin A4 and B1 differ from each other in the nature of the chromophore. Juvenimicin B3 differs from juvenimicin B1 in that a hydroxymethyl group is present at position 14 in the former.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - analysis</subject><subject>Anti-Bacterial Agents - isolation & purification</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Bacteria - drug effects</subject><subject>Chemical Phenomena</subject><subject>Chemistry</subject><subject>Mice</subject><subject>Staphylococcal Infections - prevention & control</subject><subject>Staphylococcus aureus</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkD1PwzAYhC3EVyn8AhgyMTXBH3FsjyUEMCrp0BRGy3EcCGqbEqcD_55Eqaou7zvc3XPSAXCLYMBQFD7oTVvlVd1WxgVYBAgxdAJGiHPkozASp2AEIUY-5xhegivnfiAkjDB-Ac6FIAiGIzBZZMsnmSy8eeq9LT-SVL7LWKYTb-qlyac3TTP5KOeZjANPymtwVuqVszf7PwbZc5LFr_5s_iLj6cw3RETIL3DBSNdMIKVdiSg5hbmGWvM8QsZARjQmRWkwI5SR0hpsyoKiiEZUmxySMbgfsNum_t1Z16p15YxdrfTG1junOKFUiLA3ksFomtq5xpZq21Rr3fwpBFW_kDpaSGGh-oW61N0ev8vXtjhkhkk6OR3kH9fqL3uQddNRVvYYiUTEB-z-9vyD0XzrRtkN-Qc1sXqo</recordid><startdate>1976</startdate><enddate>1976</enddate><creator>KISHI, TOYOKAZU</creator><creator>HARADA, SETSUO</creator><creator>YAMANA, HIDEO</creator><creator>MIYAKE, AKIRA</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1976</creationdate><title>STUDIES ON JUVENIMICIN, A NEW ANTIBIOTIC. II</title><author>KISHI, TOYOKAZU ; HARADA, SETSUO ; YAMANA, HIDEO ; MIYAKE, AKIRA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3961-d2d7300230551049f850ba0aa8b61cc073a23dfc273573fec2cfd516565acb03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - analysis</topic><topic>Anti-Bacterial Agents - isolation & purification</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Bacteria - drug effects</topic><topic>Chemical Phenomena</topic><topic>Chemistry</topic><topic>Mice</topic><topic>Staphylococcal Infections - prevention & control</topic><topic>Staphylococcus aureus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KISHI, TOYOKAZU</creatorcontrib><creatorcontrib>HARADA, SETSUO</creatorcontrib><creatorcontrib>YAMANA, HIDEO</creatorcontrib><creatorcontrib>MIYAKE, AKIRA</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KISHI, TOYOKAZU</au><au>HARADA, SETSUO</au><au>YAMANA, HIDEO</au><au>MIYAKE, AKIRA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>STUDIES ON JUVENIMICIN, A NEW ANTIBIOTIC. II: ISOLATION, CHEMICAL CHARACTERIZATION AND STRUCTURES</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>1976</date><risdate>1976</risdate><volume>29</volume><issue>11</issue><spage>1171</spage><epage>1181</epage><pages>1171-1181</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><abstract>A series of new macrolide antibiotics was isolated from the culture filtrate of Micromonospora chalcea var. izumensis. The fat-soluble basic complex consisted of eight components which were named juvenimicin A1-A4 and B1-B4. Juvenimicin A3 was found to be identical with rosamicin and the structures of four of the other components (JVM A2, A4, B1 and B3) have been elucidated. Juvenimicin A2 has a methyl group at position 6 instead of the formyl-methyl group of juvenimicin A3. Juvenimicin A4, B1 and B3 possess a hydroxyethyl group at position 6. Juvenimicin A4 and B1 differ from each other in the nature of the chromophore. Juvenimicin B3 differs from juvenimicin B1 in that a hydroxymethyl group is present at position 14 in the former.</abstract><cop>Japan</cop><pub>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</pub><pmid>993104</pmid><doi>10.7164/antibiotics.29.1171</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1976, Vol.29(11), pp.1171-1181 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83559940 |
| source | J-STAGE Free; MEDLINE |
| subjects | Animals Anti-Bacterial Agents - analysis Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Bacteria - drug effects Chemical Phenomena Chemistry Mice Staphylococcal Infections - prevention & control Staphylococcus aureus |
| title | STUDIES ON JUVENIMICIN, A NEW ANTIBIOTIC. II: ISOLATION, CHEMICAL CHARACTERIZATION AND STRUCTURES |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T13%3A32%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=STUDIES%20ON%20JUVENIMICIN,%20A%20NEW%20ANTIBIOTIC.%20II:%20ISOLATION,%20CHEMICAL%20CHARACTERIZATION%20AND%20STRUCTURES&rft.jtitle=Journal%20of%20antibiotics&rft.au=KISHI,%20TOYOKAZU&rft.date=1976&rft.volume=29&rft.issue=11&rft.spage=1171&rft.epage=1181&rft.pages=1171-1181&rft.issn=0021-8820&rft.eissn=1881-1469&rft_id=info:doi/10.7164/antibiotics.29.1171&rft_dat=%3Cproquest_cross%3E83559940%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=83559940&rft_id=info:pmid/993104&rfr_iscdi=true |