Effect of Aminopterin on the Replication of the Murine Salivary Gland Virus
RECENT evidence has indicated that the synthesis of DNA viruses is prevented by specific DNA inhibitors while the synthesis of RNA viruses is not affected 1–3 . On this basis, therefore, experiments were undertaken to determine if aminopterin (4 amino-pteroylglutamic acid), a folic acid antagonist,...
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| Veröffentlicht in: | Nature (London) 1964-04, Vol.202 (4930), p.419-420 |
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| creator | HENSON, DONALD PINKERTON, HENRY |
| description | RECENT evidence has indicated that the synthesis of DNA viruses is prevented by specific DNA inhibitors while the synthesis of RNA viruses is not affected
1–3
. On this basis, therefore, experiments were undertaken to determine if aminopterin (4 amino-pteroylglutamic acid), a folic acid antagonist, would block the replication of the murine salivary gland virus (MSGV) in tissue culture. In the presence of adenine and glycine the antifolic drugs have been shown specifically to block the formation of DNA in mammalian cell cultures
3
. Under such conditions the antifolics will inhibit replication of DNA but not RNA viruses
2,3
. |
| doi_str_mv | 10.1038/202419a0 |
| format | Article |
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1–3
. On this basis, therefore, experiments were undertaken to determine if aminopterin (4 amino-pteroylglutamic acid), a folic acid antagonist, would block the replication of the murine salivary gland virus (MSGV) in tissue culture. In the presence of adenine and glycine the antifolic drugs have been shown specifically to block the formation of DNA in mammalian cell cultures
3
. Under such conditions the antifolics will inhibit replication of DNA but not RNA viruses
2,3
.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/202419a0</identifier><identifier>PMID: 14152854</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adenine ; Aminopterin ; Animals ; Antiviral Agents ; Cytomegalovirus ; Cytomegalovirus Infections ; DNA Replication ; Glycine ; Humanities and Social Sciences ; letter ; Mice ; multidisciplinary ; Muromegalovirus ; Old Medline ; Pharmacology ; Science ; Science (multidisciplinary) ; Thymidine ; Tissue Culture Techniques ; Vertebrates ; Virus Cultivation ; Viruses</subject><ispartof>Nature (London), 1964-04, Vol.202 (4930), p.419-420</ispartof><rights>Springer Nature Limited 1964</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c315t-66751c9edb9ec4c4d673e79f40893cd98d50a24da76737f3f7990a082787f7d93</citedby><cites>FETCH-LOGICAL-c315t-66751c9edb9ec4c4d673e79f40893cd98d50a24da76737f3f7990a082787f7d93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/202419a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/202419a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14152854$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HENSON, DONALD</creatorcontrib><creatorcontrib>PINKERTON, HENRY</creatorcontrib><title>Effect of Aminopterin on the Replication of the Murine Salivary Gland Virus</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>RECENT evidence has indicated that the synthesis of DNA viruses is prevented by specific DNA inhibitors while the synthesis of RNA viruses is not affected
1–3
. On this basis, therefore, experiments were undertaken to determine if aminopterin (4 amino-pteroylglutamic acid), a folic acid antagonist, would block the replication of the murine salivary gland virus (MSGV) in tissue culture. In the presence of adenine and glycine the antifolic drugs have been shown specifically to block the formation of DNA in mammalian cell cultures
3
. Under such conditions the antifolics will inhibit replication of DNA but not RNA viruses
2,3
.</description><subject>Adenine</subject><subject>Aminopterin</subject><subject>Animals</subject><subject>Antiviral Agents</subject><subject>Cytomegalovirus</subject><subject>Cytomegalovirus Infections</subject><subject>DNA Replication</subject><subject>Glycine</subject><subject>Humanities and Social Sciences</subject><subject>letter</subject><subject>Mice</subject><subject>multidisciplinary</subject><subject>Muromegalovirus</subject><subject>Old Medline</subject><subject>Pharmacology</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Thymidine</subject><subject>Tissue Culture Techniques</subject><subject>Vertebrates</subject><subject>Virus Cultivation</subject><subject>Viruses</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1964</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkEtLAzEUhYMotlbBXyCzEl2M3kwyk2RZSq1iRfC1HdI8NGVeJjOC_96UVly4utx7Pg7nHoROMVxhIPw6g4xiIWEPjTFlRUoLzvbRGCDjKXBSjNBRCGsAyDGjh2iEKc4zntMxup9ba1SftDaZ1q5pu9541yRtk_QfJnkyXeWU7F3cI7E5PQxRN8mzrNyX9N_JopKNTt6cH8IxOrCyCuZkNyfo9Wb-MrtNl4-Lu9l0mSqC8z4tCpZjJYxeCaOoorpgxDBhKXBBlBZc5yAzqiWLArPEMiFAAs8YZ5ZpQSbofOvb-fZzMKEvaxeUqWIS0w6h5CQnmEMWwYstqHwbgje27LyrY-oSQ7kprvwtLqJnO89hVRv9B-6aisDlFghRat6NL9ft4Jv453-zH227c9c</recordid><startdate>19640425</startdate><enddate>19640425</enddate><creator>HENSON, DONALD</creator><creator>PINKERTON, HENRY</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19640425</creationdate><title>Effect of Aminopterin on the Replication of the Murine Salivary Gland Virus</title><author>HENSON, DONALD ; PINKERTON, HENRY</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c315t-66751c9edb9ec4c4d673e79f40893cd98d50a24da76737f3f7990a082787f7d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1964</creationdate><topic>Adenine</topic><topic>Aminopterin</topic><topic>Animals</topic><topic>Antiviral Agents</topic><topic>Cytomegalovirus</topic><topic>Cytomegalovirus Infections</topic><topic>DNA Replication</topic><topic>Glycine</topic><topic>Humanities and Social Sciences</topic><topic>letter</topic><topic>Mice</topic><topic>multidisciplinary</topic><topic>Muromegalovirus</topic><topic>Old Medline</topic><topic>Pharmacology</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Thymidine</topic><topic>Tissue Culture Techniques</topic><topic>Vertebrates</topic><topic>Virus Cultivation</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HENSON, DONALD</creatorcontrib><creatorcontrib>PINKERTON, HENRY</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HENSON, DONALD</au><au>PINKERTON, HENRY</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Aminopterin on the Replication of the Murine Salivary Gland Virus</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1964-04-25</date><risdate>1964</risdate><volume>202</volume><issue>4930</issue><spage>419</spage><epage>420</epage><pages>419-420</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>RECENT evidence has indicated that the synthesis of DNA viruses is prevented by specific DNA inhibitors while the synthesis of RNA viruses is not affected
1–3
. On this basis, therefore, experiments were undertaken to determine if aminopterin (4 amino-pteroylglutamic acid), a folic acid antagonist, would block the replication of the murine salivary gland virus (MSGV) in tissue culture. In the presence of adenine and glycine the antifolic drugs have been shown specifically to block the formation of DNA in mammalian cell cultures
3
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2,3
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| ispartof | Nature (London), 1964-04, Vol.202 (4930), p.419-420 |
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| subjects | Adenine Aminopterin Animals Antiviral Agents Cytomegalovirus Cytomegalovirus Infections DNA Replication Glycine Humanities and Social Sciences letter Mice multidisciplinary Muromegalovirus Old Medline Pharmacology Science Science (multidisciplinary) Thymidine Tissue Culture Techniques Vertebrates Virus Cultivation Viruses |
| title | Effect of Aminopterin on the Replication of the Murine Salivary Gland Virus |
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