ANTIGLOBULIN FACTOR IN SERA FROM PATIENTS WITH LIVER DISEASE
(1) An antiglobulin factor, non-neutralizable by human γ-globulin, was demonstrated in sera of two patients with liver disease. (2) By absorption and elution techniques, two fractions were differentiated in a serum: one is reactive to rabbit antibody and the other seems cross-reactive to rabbit and...
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| Veröffentlicht in: | Japanese Journal of Medical Science and Biology 1976, Vol.29(1), pp.1-9 |
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| container_title | Japanese Journal of Medical Science and Biology |
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| creator | YASUDA, JUNICHI ARAI, KAYOKO |
| description | (1) An antiglobulin factor, non-neutralizable by human γ-globulin, was demonstrated in sera of two patients with liver disease. (2) By absorption and elution techniques, two fractions were differentiated in a serum: one is reactive to rabbit antibody and the other seems cross-reactive to rabbit and human antibodies. (3) In double immunodiffusion test, the antiglobulin factor formed a precipitation band with heat-aggregated human IgG as did rheumatoid arthritis serum. (4) While the antiglobulin activity to rabbit antibody was demonstrated in both the IgM and IgG fractions, the reactivity to human antibody was localized in the IgM fraction. (5) From its selective reactivity to individual anti-D sera (sensitizers), at least a part of the specificity of the antiglobulin factor must be related to anti-Gm (1), and consequently can be regarded as auto-reactive. |
| doi_str_mv | 10.7883/yoken1952.29.1 |
| format | Article |
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(2) By absorption and elution techniques, two fractions were differentiated in a serum: one is reactive to rabbit antibody and the other seems cross-reactive to rabbit and human antibodies. (3) In double immunodiffusion test, the antiglobulin factor formed a precipitation band with heat-aggregated human IgG as did rheumatoid arthritis serum. (4) While the antiglobulin activity to rabbit antibody was demonstrated in both the IgM and IgG fractions, the reactivity to human antibody was localized in the IgM fraction. (5) From its selective reactivity to individual anti-D sera (sensitizers), at least a part of the specificity of the antiglobulin factor must be related to anti-Gm (1), and consequently can be regarded as auto-reactive.</description><identifier>ISSN: 0021-5112</identifier><identifier>EISSN: 1884-2828</identifier><identifier>DOI: 10.7883/yoken1952.29.1</identifier><identifier>PMID: 60503</identifier><language>eng</language><publisher>Japan: National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee</publisher><subject>Antibodies, Anti-Idiotypic - analysis ; Autoantibodies - analysis ; Cross Reactions ; Epitopes ; gamma-Globulins ; Humans ; Immunoglobulin Allotypes ; Immunoglobulin D ; Immunoglobulin M - analysis ; Liver Diseases - immunology ; Species Specificity</subject><ispartof>Japanese Journal of Medical Science and Biology, 1976, Vol.29(1), pp.1-9</ispartof><rights>author</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c409t-6936bd09c0da361852206b73dc823dbb70dd3e84427adb5bbac11369d9788483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/60503$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>YASUDA, JUNICHI</creatorcontrib><creatorcontrib>ARAI, KAYOKO</creatorcontrib><title>ANTIGLOBULIN FACTOR IN SERA FROM PATIENTS WITH LIVER DISEASE</title><title>Japanese Journal of Medical Science and Biology</title><addtitle>JJMSB</addtitle><description>(1) An antiglobulin factor, non-neutralizable by human γ-globulin, was demonstrated in sera of two patients with liver disease. (2) By absorption and elution techniques, two fractions were differentiated in a serum: one is reactive to rabbit antibody and the other seems cross-reactive to rabbit and human antibodies. (3) In double immunodiffusion test, the antiglobulin factor formed a precipitation band with heat-aggregated human IgG as did rheumatoid arthritis serum. (4) While the antiglobulin activity to rabbit antibody was demonstrated in both the IgM and IgG fractions, the reactivity to human antibody was localized in the IgM fraction. (5) From its selective reactivity to individual anti-D sera (sensitizers), at least a part of the specificity of the antiglobulin factor must be related to anti-Gm (1), and consequently can be regarded as auto-reactive.</description><subject>Antibodies, Anti-Idiotypic - analysis</subject><subject>Autoantibodies - analysis</subject><subject>Cross Reactions</subject><subject>Epitopes</subject><subject>gamma-Globulins</subject><subject>Humans</subject><subject>Immunoglobulin Allotypes</subject><subject>Immunoglobulin D</subject><subject>Immunoglobulin M - analysis</subject><subject>Liver Diseases - immunology</subject><subject>Species Specificity</subject><issn>0021-5112</issn><issn>1884-2828</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkM1Pg0AQxTfGRpvaqxcvnLyB-wHLknhBpC0JFgOox82yu9UqLZWlh_73ojQ9OIeZSX5vXjIPgGsEHZ8xcndovvQWBR52cOCgMzBGjLk2ZpidgzGEGNkeQvgSTI35hH1R7HsuuwAjCj1IxuA-XJbJPM0eXtJkac3CqMxyq9-KOA-tWZ49Wc9hmcTLsrDeknJhpclrnFuPSRGHRXwFRitRGz09zgkoZ3EZLew0mydRmNrShUFn04DQSsFAQiUIRczDGNLKJ0oyTFRV-VApopnrYl-oyqsqIREiNFBB_6LLyATcDra7tvnea9PxzdpIXddiq5u94Yx4BFJCe6EzCGXbGNPqFd-1641oDxxB_hsXP8XFccBRf3BzdN5XG61O8r9wehoN9NN04l2fqGi7taz1P7OhoROVH6Llekt-AHPbd7I</recordid><startdate>19760101</startdate><enddate>19760101</enddate><creator>YASUDA, JUNICHI</creator><creator>ARAI, KAYOKO</creator><general>National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19760101</creationdate><title>ANTIGLOBULIN FACTOR IN SERA FROM PATIENTS WITH LIVER DISEASE</title><author>YASUDA, JUNICHI ; ARAI, KAYOKO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-6936bd09c0da361852206b73dc823dbb70dd3e84427adb5bbac11369d9788483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>Antibodies, Anti-Idiotypic - analysis</topic><topic>Autoantibodies - analysis</topic><topic>Cross Reactions</topic><topic>Epitopes</topic><topic>gamma-Globulins</topic><topic>Humans</topic><topic>Immunoglobulin Allotypes</topic><topic>Immunoglobulin D</topic><topic>Immunoglobulin M - analysis</topic><topic>Liver Diseases - immunology</topic><topic>Species Specificity</topic><toplevel>online_resources</toplevel><creatorcontrib>YASUDA, JUNICHI</creatorcontrib><creatorcontrib>ARAI, KAYOKO</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese Journal of Medical Science and Biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YASUDA, JUNICHI</au><au>ARAI, KAYOKO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ANTIGLOBULIN FACTOR IN SERA FROM PATIENTS WITH LIVER DISEASE</atitle><jtitle>Japanese Journal of Medical Science and Biology</jtitle><addtitle>JJMSB</addtitle><date>1976-01-01</date><risdate>1976</risdate><volume>29</volume><issue>1</issue><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>0021-5112</issn><eissn>1884-2828</eissn><abstract>(1) An antiglobulin factor, non-neutralizable by human γ-globulin, was demonstrated in sera of two patients with liver disease. (2) By absorption and elution techniques, two fractions were differentiated in a serum: one is reactive to rabbit antibody and the other seems cross-reactive to rabbit and human antibodies. (3) In double immunodiffusion test, the antiglobulin factor formed a precipitation band with heat-aggregated human IgG as did rheumatoid arthritis serum. (4) While the antiglobulin activity to rabbit antibody was demonstrated in both the IgM and IgG fractions, the reactivity to human antibody was localized in the IgM fraction. (5) From its selective reactivity to individual anti-D sera (sensitizers), at least a part of the specificity of the antiglobulin factor must be related to anti-Gm (1), and consequently can be regarded as auto-reactive.</abstract><cop>Japan</cop><pub>National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee</pub><pmid>60503</pmid><doi>10.7883/yoken1952.29.1</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Japanese Journal of Medical Science and Biology, 1976, Vol.29(1), pp.1-9 |
| issn | 0021-5112 1884-2828 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83530636 |
| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Antibodies, Anti-Idiotypic - analysis Autoantibodies - analysis Cross Reactions Epitopes gamma-Globulins Humans Immunoglobulin Allotypes Immunoglobulin D Immunoglobulin M - analysis Liver Diseases - immunology Species Specificity |
| title | ANTIGLOBULIN FACTOR IN SERA FROM PATIENTS WITH LIVER DISEASE |
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