The ATP-dependent reductive carboxylation of 2-oxoglutarate using cytosol from rat liver

An enzyme system (isocitrate synthase) catalysing the conversion of 2-oxoglutarate to isocitrate has been detected in and partially purified from rat liver. The activity of this enzyme system is dependent on the presence of Mg 2+, ATP, HCO 3 − and NADPH. The major proportion of the isocitrate syntha...

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Veröffentlicht in:	Biochemical and biophysical research communications 1976-08, Vol.71 (3), p.712-718
Hauptverfasser:	Keech, D.Bruce, Mattoo, Autar K., Carabott, Mary J.J., Wallace, John C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - pharmacology Animals Cytosol - drug effects Cytosol - enzymology Enzyme Activation - drug effects Isocitrate Dehydrogenase - isolation & purification Isocitrate Dehydrogenase - metabolism Liver - enzymology Magnesium - pharmacology Multienzyme Complexes - metabolism NAD Rats
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