Mannosyltransfer reactions in rabbit liver microsomes
Rabbit liver microsomes catalyzed mannosyltransfer from GDP-[14C]mannose to free D -mannose resulting in the synthesis of α-1,2-, α-1,3-, and α-1,6-mannosyl-mannose. Whereas formation of α-1,2-mannosyl-mannose was stimulated by the addition of manganese chloride or nickel chloride and was inhibited...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1976-07, Vol.71 (1), p.203-211 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Schutzbach, J.S. Verma, A.K. |
| description | Rabbit liver microsomes catalyzed mannosyltransfer from GDP-[14C]mannose to free
D
-mannose resulting in the synthesis of α-1,2-, α-1,3-, and α-1,6-mannosyl-mannose. Whereas formation of α-1,2-mannosyl-mannose was stimulated by the addition of manganese chloride or nickel chloride and was inhibited by EDTA, synthesis of α-1,3-mannosyl-mannose was unaffected by manganese or EDTA and was inhibited by nickel. Formation of α-1,6-mannosyl-mannose appeared to be stimulated by manganese and inhibited by nickel. These results suggest that three different mannosyltransferases were involved in the synthesis of mannosyl-mannose glycosidic linkages in rabbit liver. |
| doi_str_mv | 10.1016/0006-291X(76)90269-2 |
| format | Article |
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D
-mannose resulting in the synthesis of α-1,2-, α-1,3-, and α-1,6-mannosyl-mannose. Whereas formation of α-1,2-mannosyl-mannose was stimulated by the addition of manganese chloride or nickel chloride and was inhibited by EDTA, synthesis of α-1,3-mannosyl-mannose was unaffected by manganese or EDTA and was inhibited by nickel. Formation of α-1,6-mannosyl-mannose appeared to be stimulated by manganese and inhibited by nickel. These results suggest that three different mannosyltransferases were involved in the synthesis of mannosyl-mannose glycosidic linkages in rabbit liver.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/0006-291X(76)90269-2</identifier><identifier>PMID: 822847</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Edetic Acid - pharmacology ; Guanosine Diphosphate Mannose ; Hexosyltransferases - metabolism ; Lipids ; Manganese - pharmacology ; Mannose ; Mannosidases ; Mannosyltransferases - metabolism ; Microsomes, Liver - enzymology ; Nickel - pharmacology ; Rabbits</subject><ispartof>Biochemical and biophysical research communications, 1976-07, Vol.71 (1), p.203-211</ispartof><rights>1976</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-cdecc45f077272eadbdc5e8637e52c618d57c4015a00158f74309df890707e5c3</citedby><cites>FETCH-LOGICAL-c356t-cdecc45f077272eadbdc5e8637e52c618d57c4015a00158f74309df890707e5c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0006291X76902692$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/822847$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schutzbach, J.S.</creatorcontrib><creatorcontrib>Verma, A.K.</creatorcontrib><title>Mannosyltransfer reactions in rabbit liver microsomes</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Rabbit liver microsomes catalyzed mannosyltransfer from GDP-[14C]mannose to free
D
-mannose resulting in the synthesis of α-1,2-, α-1,3-, and α-1,6-mannosyl-mannose. Whereas formation of α-1,2-mannosyl-mannose was stimulated by the addition of manganese chloride or nickel chloride and was inhibited by EDTA, synthesis of α-1,3-mannosyl-mannose was unaffected by manganese or EDTA and was inhibited by nickel. Formation of α-1,6-mannosyl-mannose appeared to be stimulated by manganese and inhibited by nickel. These results suggest that three different mannosyltransferases were involved in the synthesis of mannosyl-mannose glycosidic linkages in rabbit liver.</description><subject>Animals</subject><subject>Edetic Acid - pharmacology</subject><subject>Guanosine Diphosphate Mannose</subject><subject>Hexosyltransferases - metabolism</subject><subject>Lipids</subject><subject>Manganese - pharmacology</subject><subject>Mannose</subject><subject>Mannosidases</subject><subject>Mannosyltransferases - metabolism</subject><subject>Microsomes, Liver - enzymology</subject><subject>Nickel - pharmacology</subject><subject>Rabbits</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKxDAUhoN4G0ffYBZdiS6qJ2lz6UaQwRuMuFFwF9LkFCK9jElnYN7e1g4uXZ3Ff-E_HyELCjcUqLgFAJGygn5eSXFdABNFyg7IjEIBKaOQH5LZn-WUnMX4BUBpLooTcqwYU7mcEf5q2raLu7oPpo0VhiSgsb3v2pj4NgmmLH2f1H47KI23oYtdg_GcHFWmjnixv3Py8fjwvnxOV29PL8v7VWozLvrUOrQ25xVIySRD40pnOSqRSeTMCqoclzYHys0wjKtK5hkUrlIFSBgsNpuTy6l3HbrvDcZeNz5arGvTYreJWmWcKpWzwZhPxnFhDFjpdfCNCTtNQY-w9EhCjyS0FPoXlh5ji33_pmzQ_YUmOoN8N8k4_Lj1GHS0HluLzge0vXad_7__B-7ZeLg</recordid><startdate>19760712</startdate><enddate>19760712</enddate><creator>Schutzbach, J.S.</creator><creator>Verma, A.K.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19760712</creationdate><title>Mannosyltransfer reactions in rabbit liver microsomes</title><author>Schutzbach, J.S. ; Verma, A.K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-cdecc45f077272eadbdc5e8637e52c618d57c4015a00158f74309df890707e5c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>Animals</topic><topic>Edetic Acid - pharmacology</topic><topic>Guanosine Diphosphate Mannose</topic><topic>Hexosyltransferases - metabolism</topic><topic>Lipids</topic><topic>Manganese - pharmacology</topic><topic>Mannose</topic><topic>Mannosidases</topic><topic>Mannosyltransferases - metabolism</topic><topic>Microsomes, Liver - enzymology</topic><topic>Nickel - pharmacology</topic><topic>Rabbits</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schutzbach, J.S.</creatorcontrib><creatorcontrib>Verma, A.K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schutzbach, J.S.</au><au>Verma, A.K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mannosyltransfer reactions in rabbit liver microsomes</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1976-07-12</date><risdate>1976</risdate><volume>71</volume><issue>1</issue><spage>203</spage><epage>211</epage><pages>203-211</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Rabbit liver microsomes catalyzed mannosyltransfer from GDP-[14C]mannose to free
D
-mannose resulting in the synthesis of α-1,2-, α-1,3-, and α-1,6-mannosyl-mannose. Whereas formation of α-1,2-mannosyl-mannose was stimulated by the addition of manganese chloride or nickel chloride and was inhibited by EDTA, synthesis of α-1,3-mannosyl-mannose was unaffected by manganese or EDTA and was inhibited by nickel. Formation of α-1,6-mannosyl-mannose appeared to be stimulated by manganese and inhibited by nickel. These results suggest that three different mannosyltransferases were involved in the synthesis of mannosyl-mannose glycosidic linkages in rabbit liver.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>822847</pmid><doi>10.1016/0006-291X(76)90269-2</doi><tpages>9</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Edetic Acid - pharmacology Guanosine Diphosphate Mannose Hexosyltransferases - metabolism Lipids Manganese - pharmacology Mannose Mannosidases Mannosyltransferases - metabolism Microsomes, Liver - enzymology Nickel - pharmacology Rabbits |
| title | Mannosyltransfer reactions in rabbit liver microsomes |
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