Manganese in Melanin
AQUEOUS systems were reported earlier in which a manganese-phenothiazine auto-oxidation led to the emergence of semiquinone free-radicals of the drugs 1 . The mildness of the required conditions permitted the postulation that this interaction might be relevant to the pharmacological action of these...
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| Veröffentlicht in: | Nature (London) 1964-03, Vol.201 (4925), p.1228-1229 |
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| creator | COTZIAS, GEORGE C. PAPAVASILIOU, PAUL S. MILLER, SAMUEL T. |
| description | AQUEOUS systems were reported earlier in which a manganese-phenothiazine auto-oxidation led to the emergence of semiquinone free-radicals of the drugs
1
. The mildness of the required conditions permitted the postulation that this interaction might be relevant to the pharmacological action of these agents
2
. However, a direct biological demonstration of this specific phenomenon might require extensive technical development. Therefore, a pilot experiment was designed to discover whether manganese offered promise as a generator of free radicals in some other system of obvious biological significance. It was assumed that manganese must abound within an anatomical locus which is rich in free radicals, if this metal is indeed a biological generator of such radicals. |
| doi_str_mv | 10.1038/2011228a0 |
| format | Article |
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1
. The mildness of the required conditions permitted the postulation that this interaction might be relevant to the pharmacological action of these agents
2
. However, a direct biological demonstration of this specific phenomenon might require extensive technical development. Therefore, a pilot experiment was designed to discover whether manganese offered promise as a generator of free radicals in some other system of obvious biological significance. It was assumed that manganese must abound within an anatomical locus which is rich in free radicals, if this metal is indeed a biological generator of such radicals.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/2011228a0</identifier><identifier>PMID: 14151382</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Activation Analysis ; Animals ; Cattle ; Chemistry Techniques, Analytical ; Conjunctiva ; Dogs ; Hair ; Humanities and Social Sciences ; letter ; Manganese ; Melanins ; multidisciplinary ; Nails ; Old Medline ; Pigmentation ; Poultry ; Radioisotopes ; Science ; Science (multidisciplinary)</subject><ispartof>Nature (London), 1964-03, Vol.201 (4925), p.1228-1229</ispartof><rights>Springer Nature Limited 1964</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-e2e95407ac4817eea4ca648a4a3850634dca7795c3d9fc7c5fd1f555c4ddb6563</citedby><cites>FETCH-LOGICAL-c316t-e2e95407ac4817eea4ca648a4a3850634dca7795c3d9fc7c5fd1f555c4ddb6563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/2011228a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/2011228a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14151382$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>COTZIAS, GEORGE C.</creatorcontrib><creatorcontrib>PAPAVASILIOU, PAUL S.</creatorcontrib><creatorcontrib>MILLER, SAMUEL T.</creatorcontrib><title>Manganese in Melanin</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>AQUEOUS systems were reported earlier in which a manganese-phenothiazine auto-oxidation led to the emergence of semiquinone free-radicals of the drugs
1
. The mildness of the required conditions permitted the postulation that this interaction might be relevant to the pharmacological action of these agents
2
. However, a direct biological demonstration of this specific phenomenon might require extensive technical development. Therefore, a pilot experiment was designed to discover whether manganese offered promise as a generator of free radicals in some other system of obvious biological significance. It was assumed that manganese must abound within an anatomical locus which is rich in free radicals, if this metal is indeed a biological generator of such radicals.</description><subject>Activation Analysis</subject><subject>Animals</subject><subject>Cattle</subject><subject>Chemistry Techniques, Analytical</subject><subject>Conjunctiva</subject><subject>Dogs</subject><subject>Hair</subject><subject>Humanities and Social Sciences</subject><subject>letter</subject><subject>Manganese</subject><subject>Melanins</subject><subject>multidisciplinary</subject><subject>Nails</subject><subject>Old Medline</subject><subject>Pigmentation</subject><subject>Poultry</subject><subject>Radioisotopes</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1964</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkD1LA0EQhhdRTIwWgrWkEhROZ24_rwzBL0iw0XrZ7M2FC8le3M0V_ntXErSxmmIenpn3ZewS4R6Bm4cSEMvSODhiQxRaFUIZfcyGAKUpwHA1YGcprQBAohanbIACJXJTDtnV3IWlC5Ro3IbxnNYutOGcnTRunejiMEfs4-nxffpSzN6eX6eTWeE5ql1BJVVSgHZeGNRETninhHHCcSNBcVF7p3UlPa-rxmsvmxobKaUXdb1QUvERu9l7t7H77Cnt7KZNntb5Cer6ZA2XKPKpDN7uQR-7lCI1dhvbjYtfFsH-VGB_K8js9UHaLzZU_5GHzBm42wMpr8KSol11fQw56D-2b6ETYOQ</recordid><startdate>19640321</startdate><enddate>19640321</enddate><creator>COTZIAS, GEORGE C.</creator><creator>PAPAVASILIOU, PAUL S.</creator><creator>MILLER, SAMUEL T.</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19640321</creationdate><title>Manganese in Melanin</title><author>COTZIAS, GEORGE C. ; PAPAVASILIOU, PAUL S. ; MILLER, SAMUEL T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-e2e95407ac4817eea4ca648a4a3850634dca7795c3d9fc7c5fd1f555c4ddb6563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1964</creationdate><topic>Activation Analysis</topic><topic>Animals</topic><topic>Cattle</topic><topic>Chemistry Techniques, Analytical</topic><topic>Conjunctiva</topic><topic>Dogs</topic><topic>Hair</topic><topic>Humanities and Social Sciences</topic><topic>letter</topic><topic>Manganese</topic><topic>Melanins</topic><topic>multidisciplinary</topic><topic>Nails</topic><topic>Old Medline</topic><topic>Pigmentation</topic><topic>Poultry</topic><topic>Radioisotopes</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>COTZIAS, GEORGE C.</creatorcontrib><creatorcontrib>PAPAVASILIOU, PAUL S.</creatorcontrib><creatorcontrib>MILLER, SAMUEL T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>COTZIAS, GEORGE C.</au><au>PAPAVASILIOU, PAUL S.</au><au>MILLER, SAMUEL T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Manganese in Melanin</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1964-03-21</date><risdate>1964</risdate><volume>201</volume><issue>4925</issue><spage>1228</spage><epage>1229</epage><pages>1228-1229</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>AQUEOUS systems were reported earlier in which a manganese-phenothiazine auto-oxidation led to the emergence of semiquinone free-radicals of the drugs
1
. The mildness of the required conditions permitted the postulation that this interaction might be relevant to the pharmacological action of these agents
2
. However, a direct biological demonstration of this specific phenomenon might require extensive technical development. Therefore, a pilot experiment was designed to discover whether manganese offered promise as a generator of free radicals in some other system of obvious biological significance. It was assumed that manganese must abound within an anatomical locus which is rich in free radicals, if this metal is indeed a biological generator of such radicals.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>14151382</pmid><doi>10.1038/2011228a0</doi><tpages>2</tpages></addata></record> |
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| ispartof | Nature (London), 1964-03, Vol.201 (4925), p.1228-1229 |
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| source | MEDLINE; SpringerLink Journals; Nature Journals Online |
| subjects | Activation Analysis Animals Cattle Chemistry Techniques, Analytical Conjunctiva Dogs Hair Humanities and Social Sciences letter Manganese Melanins multidisciplinary Nails Old Medline Pigmentation Poultry Radioisotopes Science Science (multidisciplinary) |
| title | Manganese in Melanin |
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