Induction of a Protein Inhibitor to Ornithine Decarboxylase by the end Products of Its Reaction

Putrescine, the end-product of ornithine decarboxylase (ODC; L-ornithine carboxylyase, EC; 4.1.1.17) action, induces the synthesis of a protein(s), in L1210, neuroblastoma, and H-35 cells as well as in rat liver, which inhibits ODC activity. Spermidine and spermine, distal products of ODC activity,...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1976-06, Vol.73 (6), p.1858-1862
Hauptverfasser: Heller, J. S., Fong, W. F., Canellakis, E. S.
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Sprache:eng
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