Quantitative assessment of initial retention of bone marrow mononuclear cells injected into the coronary arteries

Background Intracoronary injection of bone marrow mononuclear cells (BMMNC) is a common clinical protocol of cell transplantation for heart disease, but poor engraftment of donor cells in the heart, which will limit its therapeutic efficacy, is a major issue. Initial “retention” (endothelial adheren...

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Veröffentlicht in:	The Journal of heart and lung transplantation 2011-02, Vol.30 (2), p.227-233
Hauptverfasser:	Fukushima, Satsuki, MD, PhD, Campbell, Niall G., MRCP, Coppen, Steven R., PhD, Yamahara, Kenichi, MD, PhD, Yuen, Ada H.Y., BSc, Smolenski, Ryzard T., MD, PhD, Yacoub, Magdi H., FRS, Suzuki, Ken, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Ly - metabolism Biological and medical sciences Bone Marrow Cells - cytology Bone Marrow Cells - physiology Bone Marrow Transplantation - methods bone marrow–derived stem cell Cardiology. Vascular system CD18 Antigens - metabolism cell adhesion molecules Cell Communication - physiology cell transplantation Coronary Vessels - pathology Coronary Vessels - physiology Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Endothelium, Vascular - physiopathology Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism heart Intercellular Adhesion Molecule-1 - metabolism ischemia–reperfusion Medical sciences Membrane Glycoproteins - metabolism Membrane Proteins - metabolism Mice Mice, Inbred C57BL Mice, Transgenic Models, Animal Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - physiopathology Myocardial Reperfusion Injury - therapy P-Selectin - metabolism Regional Blood Flow - physiology Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart Vascular Cell Adhesion Molecule-1 - metabolism
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