Pharmacokinetics and pharmacodynamics of rivaroxaban and its effect on biomarkers of hypercoagulability in patients with chronic heart failure

Background Heart failure (HF) is associated with a hypercoagulable state that predisposes to thromboembolism and anti-coagulation may improve clinical outcomes. The oral, direct Factor Xa inhibitor, rivaroxaban, has not been studied in patients with HF. We hypothesized that rivaroxaban would also re...

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Veröffentlicht in:	The Journal of heart and lung transplantation 2011-02, Vol.30 (2), p.218-226
Hauptverfasser:	Gheorghiade, Mihai, MD, Thyssen, An, PhD, Zolynas, Robert, DVM, MBA, Nadar, Venkatesh K., MD, Greenberg, Barry H., MD, Mehra, Mandeep, MD, Sun, Xiang, PhD, Tian, Hong, PhD, Plotnikov, Alexei N., MD, Burton, Paul, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over anti-coagulants Anticoagulants - adverse effects Anticoagulants - pharmacokinetics Anticoagulants - pharmacology Antithrombin III Biological and medical sciences Biomarkers - blood cardiac output Cardiology. Vascular system Chronic Disease Double-Blind Method drugs Enoxaparin - adverse effects Enoxaparin - pharmacokinetics Enoxaparin - pharmacology Factor Xa Inhibitors Female Fibrin Fibrinogen Degradation Products - metabolism Fibrinolytic Agents - adverse effects Fibrinolytic Agents - pharmacokinetics Fibrinolytic Agents - pharmacology Heart Heart Failure - blood Heart failure, cardiogenic pulmonary edema, cardiac enlargement Hematologic and hematopoietic diseases Humans Male Medical sciences Middle Aged Morpholines - adverse effects Morpholines - pharmacokinetics Morpholines - pharmacology Peptide Fragments - blood Peptide Hydrolases - blood pharmacokinetics Platelet diseases and coagulopathies Prothrombin Rivaroxaban Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart Thiophenes - adverse effects Thiophenes - pharmacokinetics Thiophenes - pharmacology Thrombophilia - blood thrombosis
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