miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1

Jian-Xun Wang et al . show that mitochondrial fission, which occurs during cell death, is regulated in cardiomyocytes by the microRNA miR-499 through a mechanism involving the phosphatase calcineurin and its substrate Drp1. Overexpression of miR-499 was able to reduce mitochondrial fission and apopt...

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