Unique “delta lock” structure of telmisartan is involved in its strongest binding affinity to angiotensin II type 1 receptor

► Telmisartan was the strongest ARB for the reduction of BP in patients with essential hypertension. ► Telmisartan had a unique binding mode to the AT1 receptor due to its distal benzimidazole portion. ► Due to its “delta lock” structure, telmisartan may be superior to other ARBs in halting cardiova...

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Veröffentlicht in:	Biochemical and biophysical research communications 2011-01, Vol.404 (1), p.434-437
Hauptverfasser:	Ohno, Kazuki, Amano, Yasushi, Kakuta, Hirotoshi, Niimi, Tatsuya, Takakura, Shoji, Orita, Masaya, Miyata, Keiji, Sakashita, Hitoshi, Takeuchi, Makoto, Komuro, Issei, Higaki, Jitsuo, Horiuchi, Masatsugu, Kim-Mitsuyama, Shokei, Mori, Yutaka, Morishita, Ryuichi, Yamagishi, Sho-ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	angiotensin II Angiotensin II type 1 receptor blockers Angiotensin II Type 1 Receptor Blockers - chemistry Angiotensin II Type 1 Receptor Blockers - pharmacology Animals Antihypertensive Agents - chemistry Antihypertensive Agents - pharmacology benzimidazole Benzimidazoles - chemistry Benzimidazoles - pharmacology Benzoates - chemistry Benzoates - pharmacology binding capacity blood pressure Cattle Crystallography, X-Ray Docking model Humans hydrophobicity Hypertension Hypertension - drug therapy Hypertension - metabolism meta-analysis Models, Molecular patients Receptor, Angiotensin, Type 1 - chemistry receptors Telmisartan
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