Metabolism of digitoxin in man and its modification by spironolactone

The effect of spironolactone on the metabolism of intravenously administered 3H-digitoxin (80 muCi) was investigated in eight patients. In three of them the labelled glycoside was given on a second occasion after spironolactone treatment had been discontinued for at least 65 days. Of total urinary r...

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Veröffentlicht in:	European journal of clinical pharmacology 1976-03, Vol.9 (5-6), p.345-354
Hauptverfasser:	Wirth, K E, Frölich, J C, Hollifield, J W, Falkner, F C, Sweetman, B S, Oates, J A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Chromatography, Paper Chromatography, Thin Layer Digitoxin - administration & dosage Digitoxin - metabolism Female Half-Life Humans Injections, Intravenous Kinetics Male Mass Spectrometry Metabolic Clearance Rate Middle Aged Spironolactone - pharmacology
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