Response of Luteinizing Hormone and Follicle-Stimulating Hormone to Different Doses of D-Leucine-6-Lh-Rh Ethylamide in Oligospermic Patients
The rise in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels after intramuscular administration of D-leucine-6-LH-RH ethylamide was studied in seven patients with idiopathic normogonadotropic oligospermia. Four tests with 2.5, 5.0, 10.0, and 20.0 μg of the analog, respectively,...
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| Veröffentlicht in: | Fertility and sterility 1976-05, Vol.27 (5), p.545-548 |
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| creator | Turner, Diego Turner, Elda A. Aparicio, Néstor J. Schwarzstein, Luis Coy, David H. Schally, Andrew V. |
| description | The rise in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels after intramuscular administration of D-leucine-6-LH-RH ethylamide was studied in seven patients with idiopathic normogonadotropic oligospermia. Four tests with 2.5, 5.0, 10.0, and 20.0 μg of the analog, respectively, were carried out at 8 A.M. on each subject. The interval between tests was 1 week. Serum levels of LH and FSH were determined by radioimmunoassay before (−15 and 0 minutes) and 2, 4, 6,12, and 24 hours after each injection. No differences in the basal values for either hormone were observed. D-Leucine-6-LH-RH ethylamide produced significant increases in LH and FSH levels for 6 to 12 hours after the injection. Peak values were obtained between 4 and 6 hours. A doseresponse relationship for both gonadotropins was observed. The highest average levels of LH and FSH were obtained after injection of 20.0 μg of the drug. A great individual variation in magnitude of response was observed which seemed to be related to the functional reserve of the pituitary. It is suggested that doses of 10.0 to 20.0 μg of D-leucine-6-LH-RH ethylamide/day could be used for chronic treatment in male infertility. |
| doi_str_mv | 10.1016/S0015-0282(16)41837-6 |
| format | Article |
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Four tests with 2.5, 5.0, 10.0, and 20.0 μg of the analog, respectively, were carried out at 8 A.M. on each subject. The interval between tests was 1 week. Serum levels of LH and FSH were determined by radioimmunoassay before (−15 and 0 minutes) and 2, 4, 6,12, and 24 hours after each injection. No differences in the basal values for either hormone were observed. D-Leucine-6-LH-RH ethylamide produced significant increases in LH and FSH levels for 6 to 12 hours after the injection. Peak values were obtained between 4 and 6 hours. A doseresponse relationship for both gonadotropins was observed. The highest average levels of LH and FSH were obtained after injection of 20.0 μg of the drug. A great individual variation in magnitude of response was observed which seemed to be related to the functional reserve of the pituitary. It is suggested that doses of 10.0 to 20.0 μg of D-leucine-6-LH-RH ethylamide/day could be used for chronic treatment in male infertility.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/S0015-0282(16)41837-6</identifier><identifier>PMID: 776707</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Dose-Response Relationship, Drug ; Follicle Stimulating Hormone - blood ; Gonadotropin-Releasing Hormone - administration & dosage ; Gonadotropin-Releasing Hormone - analogs & derivatives ; Gonadotropin-Releasing Hormone - pharmacology ; Gonadotropin-Releasing Hormone - therapeutic use ; Humans ; Injections, Intramuscular ; Luteinizing Hormone - blood ; Male ; Oligospermia - blood ; Oligospermia - drug therapy</subject><ispartof>Fertility and sterility, 1976-05, Vol.27 (5), p.545-548</ispartof><rights>1976 American Society for Reproductive Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-b89ed1521c74babd02f7bc47c52f611a62d513c8a83750ae7e7dc96dff4d2c083</citedby><cites>FETCH-LOGICAL-c406t-b89ed1521c74babd02f7bc47c52f611a62d513c8a83750ae7e7dc96dff4d2c083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0015-0282(16)41837-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/776707$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Turner, Diego</creatorcontrib><creatorcontrib>Turner, Elda A.</creatorcontrib><creatorcontrib>Aparicio, Néstor J.</creatorcontrib><creatorcontrib>Schwarzstein, Luis</creatorcontrib><creatorcontrib>Coy, David H.</creatorcontrib><creatorcontrib>Schally, Andrew V.</creatorcontrib><title>Response of Luteinizing Hormone and Follicle-Stimulating Hormone to Different Doses of D-Leucine-6-Lh-Rh Ethylamide in Oligospermic Patients</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>The rise in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels after intramuscular administration of D-leucine-6-LH-RH ethylamide was studied in seven patients with idiopathic normogonadotropic oligospermia. Four tests with 2.5, 5.0, 10.0, and 20.0 μg of the analog, respectively, were carried out at 8 A.M. on each subject. The interval between tests was 1 week. Serum levels of LH and FSH were determined by radioimmunoassay before (−15 and 0 minutes) and 2, 4, 6,12, and 24 hours after each injection. No differences in the basal values for either hormone were observed. D-Leucine-6-LH-RH ethylamide produced significant increases in LH and FSH levels for 6 to 12 hours after the injection. Peak values were obtained between 4 and 6 hours. A doseresponse relationship for both gonadotropins was observed. The highest average levels of LH and FSH were obtained after injection of 20.0 μg of the drug. A great individual variation in magnitude of response was observed which seemed to be related to the functional reserve of the pituitary. It is suggested that doses of 10.0 to 20.0 μg of D-leucine-6-LH-RH ethylamide/day could be used for chronic treatment in male infertility.</description><subject>Adult</subject><subject>Dose-Response Relationship, Drug</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Gonadotropin-Releasing Hormone - administration & dosage</subject><subject>Gonadotropin-Releasing Hormone - analogs & derivatives</subject><subject>Gonadotropin-Releasing Hormone - pharmacology</subject><subject>Gonadotropin-Releasing Hormone - therapeutic use</subject><subject>Humans</subject><subject>Injections, Intramuscular</subject><subject>Luteinizing Hormone - blood</subject><subject>Male</subject><subject>Oligospermia - blood</subject><subject>Oligospermia - drug therapy</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUV1rFDEUDeLXWv0HCnmS-hBNZibJ7JNIt7XCQKXV55BJbrqRmWSbZIT2N_ijzXZL8c2ny-WeD-45CL1j9COjTHy6opRxQpu-OWbiQ8f6VhLxBK0Y54JwwdunaPUIeYle5fyLUiqYbF6g51IKSeUK_bmEvIshA44OD0sBH_ydD9f4PKY5BsA6WHwWp8mbCchV8fMy6fIvoES88c5BglDwJmbIe6kNGWAxPgARZNiSyy0-LdvbSc_eAvYBX0z-OuYdpNkb_L0qVnZ-jZ45PWV48zCP0M-z0x8n52S4-Prt5MtATEdFIWO_Bst4w4zsRj1a2jg5mk4a3jjBmBaN5aw1va6JcKpBgrRmLaxznW0M7dsj9P6gu0vxZoFc1OyzgWnSAeKSVd92fSfXvAL5AWhSzDmBU7vkZ51uFaNqX4K6L0HtE1Z1uy9Bicp7-2CwjDPYR9Yh9Xr-fDhDffK3h6SyqQEYsD6BKcpG_x-DvwsWmH4</recordid><startdate>197605</startdate><enddate>197605</enddate><creator>Turner, Diego</creator><creator>Turner, Elda A.</creator><creator>Aparicio, Néstor J.</creator><creator>Schwarzstein, Luis</creator><creator>Coy, David H.</creator><creator>Schally, Andrew V.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197605</creationdate><title>Response of Luteinizing Hormone and Follicle-Stimulating Hormone to Different Doses of D-Leucine-6-Lh-Rh Ethylamide in Oligospermic Patients</title><author>Turner, Diego ; Turner, Elda A. ; Aparicio, Néstor J. ; Schwarzstein, Luis ; Coy, David H. ; Schally, Andrew V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-b89ed1521c74babd02f7bc47c52f611a62d513c8a83750ae7e7dc96dff4d2c083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>Adult</topic><topic>Dose-Response Relationship, Drug</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Gonadotropin-Releasing Hormone - administration & dosage</topic><topic>Gonadotropin-Releasing Hormone - analogs & derivatives</topic><topic>Gonadotropin-Releasing Hormone - pharmacology</topic><topic>Gonadotropin-Releasing Hormone - therapeutic use</topic><topic>Humans</topic><topic>Injections, Intramuscular</topic><topic>Luteinizing Hormone - blood</topic><topic>Male</topic><topic>Oligospermia - blood</topic><topic>Oligospermia - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Turner, Diego</creatorcontrib><creatorcontrib>Turner, Elda A.</creatorcontrib><creatorcontrib>Aparicio, Néstor J.</creatorcontrib><creatorcontrib>Schwarzstein, Luis</creatorcontrib><creatorcontrib>Coy, David H.</creatorcontrib><creatorcontrib>Schally, Andrew V.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Turner, Diego</au><au>Turner, Elda A.</au><au>Aparicio, Néstor J.</au><au>Schwarzstein, Luis</au><au>Coy, David H.</au><au>Schally, Andrew V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Response of Luteinizing Hormone and Follicle-Stimulating Hormone to Different Doses of D-Leucine-6-Lh-Rh Ethylamide in Oligospermic Patients</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>1976-05</date><risdate>1976</risdate><volume>27</volume><issue>5</issue><spage>545</spage><epage>548</epage><pages>545-548</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><abstract>The rise in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels after intramuscular administration of D-leucine-6-LH-RH ethylamide was studied in seven patients with idiopathic normogonadotropic oligospermia. Four tests with 2.5, 5.0, 10.0, and 20.0 μg of the analog, respectively, were carried out at 8 A.M. on each subject. The interval between tests was 1 week. Serum levels of LH and FSH were determined by radioimmunoassay before (−15 and 0 minutes) and 2, 4, 6,12, and 24 hours after each injection. No differences in the basal values for either hormone were observed. D-Leucine-6-LH-RH ethylamide produced significant increases in LH and FSH levels for 6 to 12 hours after the injection. Peak values were obtained between 4 and 6 hours. A doseresponse relationship for both gonadotropins was observed. The highest average levels of LH and FSH were obtained after injection of 20.0 μg of the drug. A great individual variation in magnitude of response was observed which seemed to be related to the functional reserve of the pituitary. It is suggested that doses of 10.0 to 20.0 μg of D-leucine-6-LH-RH ethylamide/day could be used for chronic treatment in male infertility.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>776707</pmid><doi>10.1016/S0015-0282(16)41837-6</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Fertility and sterility, 1976-05, Vol.27 (5), p.545-548 |
| issn | 0015-0282 1556-5653 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Dose-Response Relationship, Drug Follicle Stimulating Hormone - blood Gonadotropin-Releasing Hormone - administration & dosage Gonadotropin-Releasing Hormone - analogs & derivatives Gonadotropin-Releasing Hormone - pharmacology Gonadotropin-Releasing Hormone - therapeutic use Humans Injections, Intramuscular Luteinizing Hormone - blood Male Oligospermia - blood Oligospermia - drug therapy |
| title | Response of Luteinizing Hormone and Follicle-Stimulating Hormone to Different Doses of D-Leucine-6-Lh-Rh Ethylamide in Oligospermic Patients |
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