Some New Adrenergic Neurone Blocking Agents
INTERFERENCE with the release of the adrenergic transmitter, noradrenaline, by chemical blockade of post-ganglionic adrenergic neurones has become anaccepted tool in the management of the hypertensive state 1 . The chemical structures involved 2 indicate that the presence of a cationic head with str...
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| Veröffentlicht in: | Nature (London) 1964-02, Vol.201 (4919), p.628-629 |
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| creator | AUGSTEIN, J GREEN, S. M |
| description | INTERFERENCE with the release of the adrenergic transmitter, noradrenaline, by chemical blockade of post-ganglionic adrenergic neurones has become anaccepted tool in the management of the hypertensive state
1
. The chemical structures involved
2
indicate that the presence of a cationic head with strong basicity, such as quaternary ammonium or guanidine
3
, is required for adrenergic neurone-blocking property, imparting a high degree of ionization to the molecule. The molecular mechanism of this type of drug interference is unknown. Failure of nerve impulse transmission, however, might occur by hyper-polarization or by depolarization of the terminal nerve membrane, initiated by the charge-carrying molecules. Significant inhibition of the biosynthesis of the transmitter by the foregoing compounds can be excluded as a possible mode of action on account of more recent work
4
. |
| doi_str_mv | 10.1038/201628a0 |
| format | Article |
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1
. The chemical structures involved
2
indicate that the presence of a cationic head with strong basicity, such as quaternary ammonium or guanidine
3
, is required for adrenergic neurone-blocking property, imparting a high degree of ionization to the molecule. The molecular mechanism of this type of drug interference is unknown. Failure of nerve impulse transmission, however, might occur by hyper-polarization or by depolarization of the terminal nerve membrane, initiated by the charge-carrying molecules. Significant inhibition of the biosynthesis of the transmitter by the foregoing compounds can be excluded as a possible mode of action on account of more recent work
4
.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/201628a0</identifier><identifier>PMID: 14160665</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adrenergic Agents ; Adrenergic Antagonists ; Animals ; Antihypertensive Agents ; Cats ; Dogs ; Guanidine ; Guanidines ; Humanities and Social Sciences ; letter ; multidisciplinary ; Old Medline ; Pharmacology ; Science ; Science (multidisciplinary) ; Sympatholytics</subject><ispartof>Nature (London), 1964-02, Vol.201 (4919), p.628-629</ispartof><rights>Springer Nature Limited 1964</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c338t-ee9bb7aa3aea05c0ffa7d5b34bf82a18ef4d72a079aab86887bbbf8128ec04e23</citedby><cites>FETCH-LOGICAL-c338t-ee9bb7aa3aea05c0ffa7d5b34bf82a18ef4d72a079aab86887bbbf8128ec04e23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2727,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14160665$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>AUGSTEIN, J</creatorcontrib><creatorcontrib>GREEN, S. M</creatorcontrib><title>Some New Adrenergic Neurone Blocking Agents</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>INTERFERENCE with the release of the adrenergic transmitter, noradrenaline, by chemical blockade of post-ganglionic adrenergic neurones has become anaccepted tool in the management of the hypertensive state
1
. The chemical structures involved
2
indicate that the presence of a cationic head with strong basicity, such as quaternary ammonium or guanidine
3
, is required for adrenergic neurone-blocking property, imparting a high degree of ionization to the molecule. The molecular mechanism of this type of drug interference is unknown. Failure of nerve impulse transmission, however, might occur by hyper-polarization or by depolarization of the terminal nerve membrane, initiated by the charge-carrying molecules. Significant inhibition of the biosynthesis of the transmitter by the foregoing compounds can be excluded as a possible mode of action on account of more recent work
4
.</description><subject>Adrenergic Agents</subject><subject>Adrenergic Antagonists</subject><subject>Animals</subject><subject>Antihypertensive Agents</subject><subject>Cats</subject><subject>Dogs</subject><subject>Guanidine</subject><subject>Guanidines</subject><subject>Humanities and Social Sciences</subject><subject>letter</subject><subject>multidisciplinary</subject><subject>Old Medline</subject><subject>Pharmacology</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Sympatholytics</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1964</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1LwzAUhoMobk7BXyC9EkWqJ02aZJfb8AuGXqjXJUlPS2ebzqRF_PdWNuedV4eX9-GB8xJySuGaAlM3CVCRKA17ZEy5FDEXSu6TMUCiYlBMjMhRCCsASKnkh2REORUgRDomVy9tg9ETfkaz3KNDX1Z2iL1vHUbzurXvlSujWYmuC8fkoNB1wJPtnZC3u9vXxUO8fL5_XMyWsWVMdTHi1BipNdOoIbVQFFrmqWHcFCrRVGHBc5lokFOtjRJKSWOGiiYKLXBM2IScb7xr3370GLqsqYLFutYO2z5kinGZcjkdwIsNaH0bgsciW_uq0f4ro5D9DJP9DjOgZ1tnbxrM_8DtEgNwuQHCULkSfbZqe--GP_-ROd31HneyHfANsplz6g</recordid><startdate>19640208</startdate><enddate>19640208</enddate><creator>AUGSTEIN, J</creator><creator>GREEN, S. M</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19640208</creationdate><title>Some New Adrenergic Neurone Blocking Agents</title><author>AUGSTEIN, J ; GREEN, S. M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-ee9bb7aa3aea05c0ffa7d5b34bf82a18ef4d72a079aab86887bbbf8128ec04e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1964</creationdate><topic>Adrenergic Agents</topic><topic>Adrenergic Antagonists</topic><topic>Animals</topic><topic>Antihypertensive Agents</topic><topic>Cats</topic><topic>Dogs</topic><topic>Guanidine</topic><topic>Guanidines</topic><topic>Humanities and Social Sciences</topic><topic>letter</topic><topic>multidisciplinary</topic><topic>Old Medline</topic><topic>Pharmacology</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Sympatholytics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>AUGSTEIN, J</creatorcontrib><creatorcontrib>GREEN, S. M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>AUGSTEIN, J</au><au>GREEN, S. M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Some New Adrenergic Neurone Blocking Agents</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1964-02-08</date><risdate>1964</risdate><volume>201</volume><issue>4919</issue><spage>628</spage><epage>629</epage><pages>628-629</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>INTERFERENCE with the release of the adrenergic transmitter, noradrenaline, by chemical blockade of post-ganglionic adrenergic neurones has become anaccepted tool in the management of the hypertensive state
1
. The chemical structures involved
2
indicate that the presence of a cationic head with strong basicity, such as quaternary ammonium or guanidine
3
, is required for adrenergic neurone-blocking property, imparting a high degree of ionization to the molecule. The molecular mechanism of this type of drug interference is unknown. Failure of nerve impulse transmission, however, might occur by hyper-polarization or by depolarization of the terminal nerve membrane, initiated by the charge-carrying molecules. Significant inhibition of the biosynthesis of the transmitter by the foregoing compounds can be excluded as a possible mode of action on account of more recent work
4
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| source | MEDLINE; Nature; Alma/SFX Local Collection |
| subjects | Adrenergic Agents Adrenergic Antagonists Animals Antihypertensive Agents Cats Dogs Guanidine Guanidines Humanities and Social Sciences letter multidisciplinary Old Medline Pharmacology Science Science (multidisciplinary) Sympatholytics |
| title | Some New Adrenergic Neurone Blocking Agents |
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