The ultrastructure of benign pigmented naevi and melanocarcinomas in man
Nine benign pigmented naevi and 16 melanocarcinomas (malignant melanomas) were studied by light and transmission electron microscopy and the fine structure of benign and malignant melanocytes is described. It was found that malignant melanocytes generally exhibit a range of abnormalities of structur...
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| Veröffentlicht in: | The Journal of pathology 1976-07, Vol.119 (3), p.135-146 |
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| container_title | The Journal of pathology |
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| creator | Curran, R. C. McCann, B. G. |
| description | Nine benign pigmented naevi and 16 melanocarcinomas (malignant melanomas) were studied by light and transmission electron microscopy and the fine structure of benign and malignant melanocytes is described. It was found that malignant melanocytes generally exhibit a range of abnormalities of structure of nuclei and cytoplasmic organelles which distinguish them clearly from their benign counterparts. Of the abnormalities, those affecting the specific organelle of the melanocyte, the melanosome, were the most constantly present. No firm evidence was found for the existence of two types of melanosome or two types of melanocarcinoma. Although electron microscopy is capable of showing in great detail within individual melanocytes many changes which are clearly associated with malignancy, the technique does not appear to offer significant advantages over light microscopy in determining the diagnosis and prognosis in this group of conditions. |
| doi_str_mv | 10.1002/path.1711190303 |
| format | Article |
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C. ; McCann, B. G.</creator><creatorcontrib>Curran, R. C. ; McCann, B. G.</creatorcontrib><description>Nine benign pigmented naevi and 16 melanocarcinomas (malignant melanomas) were studied by light and transmission electron microscopy and the fine structure of benign and malignant melanocytes is described. It was found that malignant melanocytes generally exhibit a range of abnormalities of structure of nuclei and cytoplasmic organelles which distinguish them clearly from their benign counterparts. Of the abnormalities, those affecting the specific organelle of the melanocyte, the melanosome, were the most constantly present. No firm evidence was found for the existence of two types of melanosome or two types of melanocarcinoma. Although electron microscopy is capable of showing in great detail within individual melanocytes many changes which are clearly associated with malignancy, the technique does not appear to offer significant advantages over light microscopy in determining the diagnosis and prognosis in this group of conditions.</description><identifier>ISSN: 0022-3417</identifier><identifier>EISSN: 1096-9896</identifier><identifier>DOI: 10.1002/path.1711190303</identifier><identifier>PMID: 956954</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Basement Membrane - ultrastructure ; Cell Nucleus - ultrastructure ; Child ; Child, Preschool ; Desmosomes - ultrastructure ; Female ; Humans ; Male ; Melanins - analysis ; Melanocytes - ultrastructure ; Melanoma - pathology ; Middle Aged ; Mitochondria - ultrastructure ; Nevus, Pigmented - pathology ; Organoids - ultrastructure ; Prognosis ; Skin Neoplasms - pathology</subject><ispartof>The Journal of pathology, 1976-07, Vol.119 (3), p.135-146</ispartof><rights>Copyright © 1976 The Pathological Society of Great Britain and Ireland</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3813-acae303b4f90958c18b1cf911db312a2e68ceb63167254fc56da085b8ce071e3</citedby><cites>FETCH-LOGICAL-c3813-acae303b4f90958c18b1cf911db312a2e68ceb63167254fc56da085b8ce071e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpath.1711190303$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpath.1711190303$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/956954$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Curran, R. C.</creatorcontrib><creatorcontrib>McCann, B. G.</creatorcontrib><title>The ultrastructure of benign pigmented naevi and melanocarcinomas in man</title><title>The Journal of pathology</title><addtitle>J. Pathol</addtitle><description>Nine benign pigmented naevi and 16 melanocarcinomas (malignant melanomas) were studied by light and transmission electron microscopy and the fine structure of benign and malignant melanocytes is described. It was found that malignant melanocytes generally exhibit a range of abnormalities of structure of nuclei and cytoplasmic organelles which distinguish them clearly from their benign counterparts. Of the abnormalities, those affecting the specific organelle of the melanocyte, the melanosome, were the most constantly present. No firm evidence was found for the existence of two types of melanosome or two types of melanocarcinoma. Although electron microscopy is capable of showing in great detail within individual melanocytes many changes which are clearly associated with malignancy, the technique does not appear to offer significant advantages over light microscopy in determining the diagnosis and prognosis in this group of conditions.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Basement Membrane - ultrastructure</subject><subject>Cell Nucleus - ultrastructure</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Desmosomes - ultrastructure</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Melanins - analysis</subject><subject>Melanocytes - ultrastructure</subject><subject>Melanoma - pathology</subject><subject>Middle Aged</subject><subject>Mitochondria - ultrastructure</subject><subject>Nevus, Pigmented - pathology</subject><subject>Organoids - ultrastructure</subject><subject>Prognosis</subject><subject>Skin Neoplasms - pathology</subject><issn>0022-3417</issn><issn>1096-9896</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDtP7DAUhC10eSyPmuYWrugCPnHsxLoVQrCLhADBSpSW45yAIXEWO-Hx7wkKAlHd6khnvhmNhpB9YIfAWHq0Mv3DIeQAoBhnfI3MgCmZqELJP2Q2EmnCM8i3yHaMj4wxpYTYJBtKSCWyGVksH5AOTR9M7MNg-yEg7Wpaonf3nq7cfYu-x4p6gy-OGl_RFhvjO2uCdb5rTaTO09b4XbJemybi3tfdIcuz0-XJIrm4mp-fHF8klhfAE2MNjjXLrFZMicJCUYKtFUBVckhNirKwWEoOMk9FVlshK8MKUY5flgPyHXIwxa5C9zxg7HXrosVm7ITdEHXBs5xLpUbwaAJt6GIMWOtVcK0J7xqY_lxOfy6nf5YbHX-_ooeyxeqbn6Ya5X-T_OoafP9fmr4-Xi5-hSeT28Ue377dJjxpmfNc6LvLuVZ36nIxv5X6hn8ALFmKvQ</recordid><startdate>197607</startdate><enddate>197607</enddate><creator>Curran, R. C.</creator><creator>McCann, B. G.</creator><general>John Wiley & Sons, Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197607</creationdate><title>The ultrastructure of benign pigmented naevi and melanocarcinomas in man</title><author>Curran, R. C. ; McCann, B. G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3813-acae303b4f90958c18b1cf911db312a2e68ceb63167254fc56da085b8ce071e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Basement Membrane - ultrastructure</topic><topic>Cell Nucleus - ultrastructure</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Desmosomes - ultrastructure</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Melanins - analysis</topic><topic>Melanocytes - ultrastructure</topic><topic>Melanoma - pathology</topic><topic>Middle Aged</topic><topic>Mitochondria - ultrastructure</topic><topic>Nevus, Pigmented - pathology</topic><topic>Organoids - ultrastructure</topic><topic>Prognosis</topic><topic>Skin Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Curran, R. C.</creatorcontrib><creatorcontrib>McCann, B. G.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Curran, R. C.</au><au>McCann, B. G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The ultrastructure of benign pigmented naevi and melanocarcinomas in man</atitle><jtitle>The Journal of pathology</jtitle><addtitle>J. Pathol</addtitle><date>1976-07</date><risdate>1976</risdate><volume>119</volume><issue>3</issue><spage>135</spage><epage>146</epage><pages>135-146</pages><issn>0022-3417</issn><eissn>1096-9896</eissn><abstract>Nine benign pigmented naevi and 16 melanocarcinomas (malignant melanomas) were studied by light and transmission electron microscopy and the fine structure of benign and malignant melanocytes is described. It was found that malignant melanocytes generally exhibit a range of abnormalities of structure of nuclei and cytoplasmic organelles which distinguish them clearly from their benign counterparts. Of the abnormalities, those affecting the specific organelle of the melanocyte, the melanosome, were the most constantly present. No firm evidence was found for the existence of two types of melanosome or two types of melanocarcinoma. Although electron microscopy is capable of showing in great detail within individual melanocytes many changes which are clearly associated with malignancy, the technique does not appear to offer significant advantages over light microscopy in determining the diagnosis and prognosis in this group of conditions.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>956954</pmid><doi>10.1002/path.1711190303</doi><tpages>12</tpages></addata></record> |
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| ispartof | The Journal of pathology, 1976-07, Vol.119 (3), p.135-146 |
| issn | 0022-3417 1096-9896 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adult Aged Basement Membrane - ultrastructure Cell Nucleus - ultrastructure Child Child, Preschool Desmosomes - ultrastructure Female Humans Male Melanins - analysis Melanocytes - ultrastructure Melanoma - pathology Middle Aged Mitochondria - ultrastructure Nevus, Pigmented - pathology Organoids - ultrastructure Prognosis Skin Neoplasms - pathology |
| title | The ultrastructure of benign pigmented naevi and melanocarcinomas in man |
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