ROLE OF THE RENIN-ANGIOTENSIN SYSTEM IN HYPERTENSION PRODUCED BY UNILATERAL RENAL ARTERY CONSTRICTION IN THE RAT
SUMMARY 1. Conscious rats which had undergone unilateral renal artery constriction were infused for 1 h with a specific antagonist of angiotensin II, 1‐Sar‐8‐Ala‐angiotensin II (P‐113). 2. There was a highly significant correlation between the change in blood pressure induced by P‐113 and the pre‐in...
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| Veröffentlicht in: | Clinical and experimental pharmacology & physiology 1976-01, Vol.3 (1), p.95-98 |
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| container_title | Clinical and experimental pharmacology & physiology |
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| creator | Oates, Helen F. |
| description | SUMMARY
1. Conscious rats which had undergone unilateral renal artery constriction were infused for 1 h with a specific antagonist of angiotensin II, 1‐Sar‐8‐Ala‐angiotensin II (P‐113).
2. There was a highly significant correlation between the change in blood pressure induced by P‐113 and the pre‐infusion plasma renin concentration (PRC), regardless of initial blood pressure or the duration of stenosis. However, the blood pressure fall was not significantly greater in nineteen hypertensive rats than in eleven which remained normotensive. P‐113 did not abolish the hypertension.
3. The extent to which angiotensin II supports blood pressure in rats with renal artery constriction is directly related to the PRC. |
| doi_str_mv | 10.1111/j.1440-1681.1976.tb00594.x |
| format | Article |
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1. Conscious rats which had undergone unilateral renal artery constriction were infused for 1 h with a specific antagonist of angiotensin II, 1‐Sar‐8‐Ala‐angiotensin II (P‐113).
2. There was a highly significant correlation between the change in blood pressure induced by P‐113 and the pre‐infusion plasma renin concentration (PRC), regardless of initial blood pressure or the duration of stenosis. However, the blood pressure fall was not significantly greater in nineteen hypertensive rats than in eleven which remained normotensive. P‐113 did not abolish the hypertension.
3. The extent to which angiotensin II supports blood pressure in rats with renal artery constriction is directly related to the PRC.</description><identifier>ISSN: 0305-1870</identifier><identifier>EISSN: 1440-1681</identifier><identifier>DOI: 10.1111/j.1440-1681.1976.tb00594.x</identifier><identifier>PMID: 971555</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>angiotensin antagonist ; Angiotensin II - physiology ; Animals ; Blood Pressure - drug effects ; conscious rat ; Female ; plasma renin concentration ; Rats ; Renal Artery Obstruction - physiopathology ; Renin - blood ; Renin - physiology ; renin-angiotensin system ; renovascular hypertension ; Saralasin - pharmacology</subject><ispartof>Clinical and experimental pharmacology & physiology, 1976-01, Vol.3 (1), p.95-98</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4055-2969afe0f3f4dac98d8eeec332dc5752ad75a0936abd2cee2d954c5c2bec31123</citedby><cites>FETCH-LOGICAL-c4055-2969afe0f3f4dac98d8eeec332dc5752ad75a0936abd2cee2d954c5c2bec31123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1440-1681.1976.tb00594.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1440-1681.1976.tb00594.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/971555$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oates, Helen F.</creatorcontrib><title>ROLE OF THE RENIN-ANGIOTENSIN SYSTEM IN HYPERTENSION PRODUCED BY UNILATERAL RENAL ARTERY CONSTRICTION IN THE RAT</title><title>Clinical and experimental pharmacology & physiology</title><addtitle>Clin Exp Pharmacol Physiol</addtitle><description>SUMMARY
1. Conscious rats which had undergone unilateral renal artery constriction were infused for 1 h with a specific antagonist of angiotensin II, 1‐Sar‐8‐Ala‐angiotensin II (P‐113).
2. There was a highly significant correlation between the change in blood pressure induced by P‐113 and the pre‐infusion plasma renin concentration (PRC), regardless of initial blood pressure or the duration of stenosis. However, the blood pressure fall was not significantly greater in nineteen hypertensive rats than in eleven which remained normotensive. P‐113 did not abolish the hypertension.
3. The extent to which angiotensin II supports blood pressure in rats with renal artery constriction is directly related to the PRC.</description><subject>angiotensin antagonist</subject><subject>Angiotensin II - physiology</subject><subject>Animals</subject><subject>Blood Pressure - drug effects</subject><subject>conscious rat</subject><subject>Female</subject><subject>plasma renin concentration</subject><subject>Rats</subject><subject>Renal Artery Obstruction - physiopathology</subject><subject>Renin - blood</subject><subject>Renin - physiology</subject><subject>renin-angiotensin system</subject><subject>renovascular hypertension</subject><subject>Saralasin - pharmacology</subject><issn>0305-1870</issn><issn>1440-1681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkM2OmzAUha2qf-m0b9CF1UV3UBtjwJW6oIwnQSUmAtIqK8sxRkqaTFKcqJm3rxmi7OuFfeVzvnOlA8AnjHzszpetj8MQeThKsI9ZHPmnNUKUhf7lBZjcpJdgggiiHk5i9Ba8s3aLnAtF5A14zWJMKZ2AY1UWHJYPsJlxWHGRCy8V07xsuKhzAetV3fA5dNNsteDV828p4KIq75cZv4ffV3Ap8iJteJUWA-_u1NmqFcxKUTdVnjUD4AKeF6TNe_CqUztrPlzfO7B84E0284pymmdp4ekQUeoFLGKqM6gjXdgqzZI2McZoQoJW05gGqo2pQoxEat0G2pigZTTUVAdrZ8I4IHfg85h77A9_zsae5H5jtdnt1KM5nK1MSBiRKEbO-HU06v5gbW86eew3e9U_SYzk0LbcyqFSOVQqh7bltW15cfDH65bzem_aGzrW6-Rvo_x3szNP_xEsM75gA--N_MaezOXGq_63jGISU_lLTOU8WdTzefxD_iT_ACaYldI</recordid><startdate>19760101</startdate><enddate>19760101</enddate><creator>Oates, Helen F.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19760101</creationdate><title>ROLE OF THE RENIN-ANGIOTENSIN SYSTEM IN HYPERTENSION PRODUCED BY UNILATERAL RENAL ARTERY CONSTRICTION IN THE RAT</title><author>Oates, Helen F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4055-2969afe0f3f4dac98d8eeec332dc5752ad75a0936abd2cee2d954c5c2bec31123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>angiotensin antagonist</topic><topic>Angiotensin II - physiology</topic><topic>Animals</topic><topic>Blood Pressure - drug effects</topic><topic>conscious rat</topic><topic>Female</topic><topic>plasma renin concentration</topic><topic>Rats</topic><topic>Renal Artery Obstruction - physiopathology</topic><topic>Renin - blood</topic><topic>Renin - physiology</topic><topic>renin-angiotensin system</topic><topic>renovascular hypertension</topic><topic>Saralasin - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oates, Helen F.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental pharmacology & physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oates, Helen F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ROLE OF THE RENIN-ANGIOTENSIN SYSTEM IN HYPERTENSION PRODUCED BY UNILATERAL RENAL ARTERY CONSTRICTION IN THE RAT</atitle><jtitle>Clinical and experimental pharmacology & physiology</jtitle><addtitle>Clin Exp Pharmacol Physiol</addtitle><date>1976-01-01</date><risdate>1976</risdate><volume>3</volume><issue>1</issue><spage>95</spage><epage>98</epage><pages>95-98</pages><issn>0305-1870</issn><eissn>1440-1681</eissn><abstract>SUMMARY
1. Conscious rats which had undergone unilateral renal artery constriction were infused for 1 h with a specific antagonist of angiotensin II, 1‐Sar‐8‐Ala‐angiotensin II (P‐113).
2. There was a highly significant correlation between the change in blood pressure induced by P‐113 and the pre‐infusion plasma renin concentration (PRC), regardless of initial blood pressure or the duration of stenosis. However, the blood pressure fall was not significantly greater in nineteen hypertensive rats than in eleven which remained normotensive. P‐113 did not abolish the hypertension.
3. The extent to which angiotensin II supports blood pressure in rats with renal artery constriction is directly related to the PRC.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>971555</pmid><doi>10.1111/j.1440-1681.1976.tb00594.x</doi><tpages>4</tpages></addata></record> |
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| ispartof | Clinical and experimental pharmacology & physiology, 1976-01, Vol.3 (1), p.95-98 |
| issn | 0305-1870 1440-1681 |
| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | angiotensin antagonist Angiotensin II - physiology Animals Blood Pressure - drug effects conscious rat Female plasma renin concentration Rats Renal Artery Obstruction - physiopathology Renin - blood Renin - physiology renin-angiotensin system renovascular hypertension Saralasin - pharmacology |
| title | ROLE OF THE RENIN-ANGIOTENSIN SYSTEM IN HYPERTENSION PRODUCED BY UNILATERAL RENAL ARTERY CONSTRICTION IN THE RAT |
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