Immunopathology of schistosomiasis in athymic mice
EOSINOPHILIA—tissue eosinophil infiltrates—granuloma and IgE formation are associated with helminth infections. Eosinophils phagocytose antigen-antibody complexes, neutralise histamine and serotonin, mediate inflammatory reactions and modify delayed hypersensitivity 1 . The tissue-invasive stage of...
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| Veröffentlicht in: | Nature (London) 1976-07, Vol.262 (5567), p.397-399 |
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| creator | Hsu, CHAO-KUANG Hsu, SUSAN H WHITNEY, ROBERT A HANSEN, CARL T |
| description | EOSINOPHILIA—tissue eosinophil infiltrates—granuloma and IgE formation are associated with helminth infections. Eosinophils phagocytose antigen-antibody complexes, neutralise histamine and serotonin, mediate inflammatory reactions and modify delayed hypersensitivity
1
. The tissue-invasive stage of some parasitic infections provides suitable antigen and stimulates the production of IgE, which in turn induce eosinophilotaxis. We have investigated the need of T-cell participation in the eosinophil response, IgE formation and granuloma formation in schistosomiasis in con-genitally athymic mice which have profound deficiency in T-cell dependent immune response. We looked in particular at eggs as they are important in the pathogenesis of schistosomiasis. They are trapped in tissues and induce chronic granulomatous inflammation with numerous eosinophils. Warren
et al.
2–6
reported that egg granuloma is a cell-mediated hypersensitivity reaction and it is significantly altered in immunosuppressed mice. |
| doi_str_mv | 10.1038/262397a0 |
| format | Article |
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1
. The tissue-invasive stage of some parasitic infections provides suitable antigen and stimulates the production of IgE, which in turn induce eosinophilotaxis. We have investigated the need of T-cell participation in the eosinophil response, IgE formation and granuloma formation in schistosomiasis in con-genitally athymic mice which have profound deficiency in T-cell dependent immune response. We looked in particular at eggs as they are important in the pathogenesis of schistosomiasis. They are trapped in tissues and induce chronic granulomatous inflammation with numerous eosinophils. Warren
et al.
2–6
reported that egg granuloma is a cell-mediated hypersensitivity reaction and it is significantly altered in immunosuppressed mice.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/262397a0</identifier><identifier>PMID: 1085416</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Antibody Formation ; B-Lymphocytes - immunology ; Blood Cell Count ; Eosinophils - immunology ; Granuloma - immunology ; Granuloma - pathology ; Humanities and Social Sciences ; Immunoglobulin Allotypes ; Immunoglobulin E - biosynthesis ; Immunoglobulin G - biosynthesis ; letter ; Liver - pathology ; Lymphocyte Activation ; Mice ; Mice, Nude - immunology ; multidisciplinary ; Schistosoma mansoni - immunology ; Schistosomiasis - blood ; Schistosomiasis - immunology ; Schistosomiasis - pathology ; Science ; T-Lymphocytes - immunology</subject><ispartof>Nature (London), 1976-07, Vol.262 (5567), p.397-399</ispartof><rights>Springer Nature Limited 1976</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c335t-28342ea999c450667eccaef4cd6b2d2e8f5316258e0d3919a09b1e3a6d382dae3</citedby><cites>FETCH-LOGICAL-c335t-28342ea999c450667eccaef4cd6b2d2e8f5316258e0d3919a09b1e3a6d382dae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/262397a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/262397a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,2725,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1085416$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hsu, CHAO-KUANG</creatorcontrib><creatorcontrib>Hsu, SUSAN H</creatorcontrib><creatorcontrib>WHITNEY, ROBERT A</creatorcontrib><creatorcontrib>HANSEN, CARL T</creatorcontrib><title>Immunopathology of schistosomiasis in athymic mice</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>EOSINOPHILIA—tissue eosinophil infiltrates—granuloma and IgE formation are associated with helminth infections. Eosinophils phagocytose antigen-antibody complexes, neutralise histamine and serotonin, mediate inflammatory reactions and modify delayed hypersensitivity
1
. The tissue-invasive stage of some parasitic infections provides suitable antigen and stimulates the production of IgE, which in turn induce eosinophilotaxis. We have investigated the need of T-cell participation in the eosinophil response, IgE formation and granuloma formation in schistosomiasis in con-genitally athymic mice which have profound deficiency in T-cell dependent immune response. We looked in particular at eggs as they are important in the pathogenesis of schistosomiasis. They are trapped in tissues and induce chronic granulomatous inflammation with numerous eosinophils. Warren
et al.
2–6
reported that egg granuloma is a cell-mediated hypersensitivity reaction and it is significantly altered in immunosuppressed mice.</description><subject>Animals</subject><subject>Antibody Formation</subject><subject>B-Lymphocytes - immunology</subject><subject>Blood Cell Count</subject><subject>Eosinophils - immunology</subject><subject>Granuloma - immunology</subject><subject>Granuloma - pathology</subject><subject>Humanities and Social Sciences</subject><subject>Immunoglobulin Allotypes</subject><subject>Immunoglobulin E - biosynthesis</subject><subject>Immunoglobulin G - biosynthesis</subject><subject>letter</subject><subject>Liver - pathology</subject><subject>Lymphocyte Activation</subject><subject>Mice</subject><subject>Mice, Nude - immunology</subject><subject>multidisciplinary</subject><subject>Schistosoma mansoni - immunology</subject><subject>Schistosomiasis - blood</subject><subject>Schistosomiasis - immunology</subject><subject>Schistosomiasis - pathology</subject><subject>Science</subject><subject>T-Lymphocytes - immunology</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkDtPwzAURi0EKqUg8QdAmRAMgetHHHtEFY9KlVhgjlznpk3VxMVOhv57DCkVA4N1h3N0JH-EXFK4p8DVA5OM69zAERlTkctUSJUfkzEAUykoLk_JWQhrAMhoLkZkREFlgsoxYbOm6Vu3Nd3Kbdxyl7gqCXZVh84F19Qm1CGp2yTiXVPbJD48JyeV2QS82N8J-Xh-ep--pvO3l9n0cZ5azrMuZYoLhkZrbUUGUuZorcFK2FIuWMlQVRmnkmUKoeSaagN6QZEbWXLFSoN8Qm6G7ta7zx5DVzR1sLjZmBZdH4rYFxpyEcXbQbTeheCxKra-bozfFRSK73mK33mierVv9osGyz_izx6R3w08RNIu0Rdr1_s2fvO_1vXgtqbrPR5aB-ELNyd2NQ</recordid><startdate>19760729</startdate><enddate>19760729</enddate><creator>Hsu, CHAO-KUANG</creator><creator>Hsu, SUSAN H</creator><creator>WHITNEY, ROBERT A</creator><creator>HANSEN, CARL T</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19760729</creationdate><title>Immunopathology of schistosomiasis in athymic mice</title><author>Hsu, CHAO-KUANG ; Hsu, SUSAN H ; WHITNEY, ROBERT A ; HANSEN, CARL T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-28342ea999c450667eccaef4cd6b2d2e8f5316258e0d3919a09b1e3a6d382dae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>Animals</topic><topic>Antibody Formation</topic><topic>B-Lymphocytes - immunology</topic><topic>Blood Cell Count</topic><topic>Eosinophils - immunology</topic><topic>Granuloma - immunology</topic><topic>Granuloma - pathology</topic><topic>Humanities and Social Sciences</topic><topic>Immunoglobulin Allotypes</topic><topic>Immunoglobulin E - biosynthesis</topic><topic>Immunoglobulin G - biosynthesis</topic><topic>letter</topic><topic>Liver - pathology</topic><topic>Lymphocyte Activation</topic><topic>Mice</topic><topic>Mice, Nude - immunology</topic><topic>multidisciplinary</topic><topic>Schistosoma mansoni - immunology</topic><topic>Schistosomiasis - blood</topic><topic>Schistosomiasis - immunology</topic><topic>Schistosomiasis - pathology</topic><topic>Science</topic><topic>T-Lymphocytes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hsu, CHAO-KUANG</creatorcontrib><creatorcontrib>Hsu, SUSAN H</creatorcontrib><creatorcontrib>WHITNEY, ROBERT A</creatorcontrib><creatorcontrib>HANSEN, CARL T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hsu, CHAO-KUANG</au><au>Hsu, SUSAN H</au><au>WHITNEY, ROBERT A</au><au>HANSEN, CARL T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunopathology of schistosomiasis in athymic mice</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1976-07-29</date><risdate>1976</risdate><volume>262</volume><issue>5567</issue><spage>397</spage><epage>399</epage><pages>397-399</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>EOSINOPHILIA—tissue eosinophil infiltrates—granuloma and IgE formation are associated with helminth infections. Eosinophils phagocytose antigen-antibody complexes, neutralise histamine and serotonin, mediate inflammatory reactions and modify delayed hypersensitivity
1
. The tissue-invasive stage of some parasitic infections provides suitable antigen and stimulates the production of IgE, which in turn induce eosinophilotaxis. We have investigated the need of T-cell participation in the eosinophil response, IgE formation and granuloma formation in schistosomiasis in con-genitally athymic mice which have profound deficiency in T-cell dependent immune response. We looked in particular at eggs as they are important in the pathogenesis of schistosomiasis. They are trapped in tissues and induce chronic granulomatous inflammation with numerous eosinophils. Warren
et al.
2–6
reported that egg granuloma is a cell-mediated hypersensitivity reaction and it is significantly altered in immunosuppressed mice.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>1085416</pmid><doi>10.1038/262397a0</doi><tpages>3</tpages></addata></record> |
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| ispartof | Nature (London), 1976-07, Vol.262 (5567), p.397-399 |
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| subjects | Animals Antibody Formation B-Lymphocytes - immunology Blood Cell Count Eosinophils - immunology Granuloma - immunology Granuloma - pathology Humanities and Social Sciences Immunoglobulin Allotypes Immunoglobulin E - biosynthesis Immunoglobulin G - biosynthesis letter Liver - pathology Lymphocyte Activation Mice Mice, Nude - immunology multidisciplinary Schistosoma mansoni - immunology Schistosomiasis - blood Schistosomiasis - immunology Schistosomiasis - pathology Science T-Lymphocytes - immunology |
| title | Immunopathology of schistosomiasis in athymic mice |
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