Immunological relationships among hexosaminidases of different species
The immunological inter-relationship between hexosaminidases of several mammals were established. Qualitative immunochemical analysis indicated similarity between the enzymes derived from man, Rhesus monkey, Iris maccaque, bovine, pig, goat and guinea-pig. Quantitation of the extent of antigenic sim...
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| Veröffentlicht in: | Immunochemistry (1965) 1976-06, Vol.13 (6), p.485-490 |
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| container_end_page | 490 |
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| container_title | Immunochemistry (1965) |
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| creator | Geiger, Benjamin Ben-Yoseph, Yoav Arnon, Ruth |
| description | The immunological inter-relationship between hexosaminidases of several mammals were established. Qualitative immunochemical analysis indicated similarity between the enzymes derived from man, Rhesus monkey, Iris maccaque, bovine, pig, goat and guinea-pig. Quantitation of the extent of antigenic similarity among the various species, using antigen binding assay and radioimmunoassay, correlated well with the phylogenetic relationships between the species investigated. The evolutionary distance between the species used as sources of enzyme and the immunized animal effects the capacity to distinguish between closely related enzymes. Thus, the use of closer animals for immunization enables the detection of subtle differences between the tested enzymes, whereas a phylogenetically remote animal recognizes better their similarity. |
| doi_str_mv | 10.1016/0019-2791(76)90323-2 |
| format | Article |
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Qualitative immunochemical analysis indicated similarity between the enzymes derived from man, Rhesus monkey, Iris maccaque, bovine, pig, goat and guinea-pig. Quantitation of the extent of antigenic similarity among the various species, using antigen binding assay and radioimmunoassay, correlated well with the phylogenetic relationships between the species investigated. The evolutionary distance between the species used as sources of enzyme and the immunized animal effects the capacity to distinguish between closely related enzymes. Thus, the use of closer animals for immunization enables the detection of subtle differences between the tested enzymes, whereas a phylogenetically remote animal recognizes better their similarity.</description><subject>Animals</subject><subject>Cattle</subject><subject>Chickens</subject><subject>Cross Reactions</subject><subject>Epitopes</subject><subject>Goats</subject><subject>Guinea Pigs</subject><subject>Haplorhini</subject><subject>Hexosaminidases - immunology</subject><subject>Humans</subject><subject>Immunodiffusion</subject><subject>Macaca</subject><subject>Mice</subject><subject>Phylogeny</subject><subject>Protein Binding</subject><subject>Rabbits</subject><subject>Radioimmunoassay</subject><subject>Rats</subject><subject>Species Specificity</subject><issn>0019-2791</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDFPwzAQhT1QQSn8AhgyIRgCdhwn8YKEKgqVKrHAbDn2pTVK4uJLEPx7krbqyHS6e_fe6T5Crhm9Z5RlD5QyGSe5ZLd5dicpT3icnJDpcXxGzhE_x1am8pRMhMykmJLFsmn61td-7YyuowC17pxvceO2GOnGt-toAz8edeNaZzUCRr6KrKsqCNB2EW7BOMALMql0jXB5qDPysXh-n7_Gq7eX5fxpFRsuRBeLfLieC8PAaGplQQuuWamTHCRjlhZFybLUljSrcs4EFFxQWUgmElkarbXlM3Kzz90G_9UDdqpxaKCudQu-R1XwNGVCyGEx3S-a4BEDVGobXKPDr2JUjcDUiEKNZFSeqR0wlQy2q0N-XzZgj6YdrUF93KswvPjtICgcnm8NWBfAdMp693_8H2hKfFM</recordid><startdate>197606</startdate><enddate>197606</enddate><creator>Geiger, Benjamin</creator><creator>Ben-Yoseph, Yoav</creator><creator>Arnon, Ruth</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197606</creationdate><title>Immunological relationships among hexosaminidases of different species</title><author>Geiger, Benjamin ; Ben-Yoseph, Yoav ; Arnon, Ruth</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c355t-5799475c1eca0d98083a1ba27e911d088b164db06f7315e83509891529bcaaad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>Animals</topic><topic>Cattle</topic><topic>Chickens</topic><topic>Cross Reactions</topic><topic>Epitopes</topic><topic>Goats</topic><topic>Guinea Pigs</topic><topic>Haplorhini</topic><topic>Hexosaminidases - immunology</topic><topic>Humans</topic><topic>Immunodiffusion</topic><topic>Macaca</topic><topic>Mice</topic><topic>Phylogeny</topic><topic>Protein Binding</topic><topic>Rabbits</topic><topic>Radioimmunoassay</topic><topic>Rats</topic><topic>Species Specificity</topic><toplevel>online_resources</toplevel><creatorcontrib>Geiger, Benjamin</creatorcontrib><creatorcontrib>Ben-Yoseph, Yoav</creatorcontrib><creatorcontrib>Arnon, Ruth</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Immunochemistry (1965)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Geiger, Benjamin</au><au>Ben-Yoseph, Yoav</au><au>Arnon, Ruth</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunological relationships among hexosaminidases of different species</atitle><jtitle>Immunochemistry (1965)</jtitle><addtitle>Immunochemistry</addtitle><date>1976-06</date><risdate>1976</risdate><volume>13</volume><issue>6</issue><spage>485</spage><epage>490</epage><pages>485-490</pages><issn>0019-2791</issn><abstract>The immunological inter-relationship between hexosaminidases of several mammals were established. Qualitative immunochemical analysis indicated similarity between the enzymes derived from man, Rhesus monkey, Iris maccaque, bovine, pig, goat and guinea-pig. Quantitation of the extent of antigenic similarity among the various species, using antigen binding assay and radioimmunoassay, correlated well with the phylogenetic relationships between the species investigated. The evolutionary distance between the species used as sources of enzyme and the immunized animal effects the capacity to distinguish between closely related enzymes. Thus, the use of closer animals for immunization enables the detection of subtle differences between the tested enzymes, whereas a phylogenetically remote animal recognizes better their similarity.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>59695</pmid><doi>10.1016/0019-2791(76)90323-2</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0019-2791 |
| ispartof | Immunochemistry (1965), 1976-06, Vol.13 (6), p.485-490 |
| issn | 0019-2791 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83441559 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Cattle Chickens Cross Reactions Epitopes Goats Guinea Pigs Haplorhini Hexosaminidases - immunology Humans Immunodiffusion Macaca Mice Phylogeny Protein Binding Rabbits Radioimmunoassay Rats Species Specificity |
| title | Immunological relationships among hexosaminidases of different species |
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