Capacity of Old Versus Young Female Rats to Secrete LH, FSH and Prolactin
Serum LH, FSH and prolactin levels were measured by radioimmunoassays before and after ovariectomy and during and after estradiol benzoate (EB) treatment in 4-5 month old young mature female rats, in 22-24 month old constant estrous and pseudopregnant rats, and in 26-30 month old anestrous rats. Ser...
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| Veröffentlicht in: | Biology of reproduction 1976-06, Vol.14 (5), p.538-543 |
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| creator | Huang, H H Marshall, S Meites, J |
| description | Serum LH, FSH and prolactin levels were measured by radioimmunoassays before and after
ovariectomy and during and after estradiol benzoate (EB) treatment in 4-5 month old young
mature female rats, in 22-24 month old constant estrous and pseudopregnant rats, and in 26-30
month old anestrous rats. Serum LH in intact old constant estrous rats was significantly higher
than in young rats on the day of estrus, about the same in intact old pseudopregnant rats as in
young rats in diestrus, and was undetectable in the old anestrous rats. By 7 weeks after
ovariectomy, serum LH rose about 26 fold in young rats, only about 3 fold in the old constant
estrous rats, about 14 fold in the old pseudopregnant rats, and remained unmeasurable in the old
anestrous rats. After daily EB injection for 8 days, the relative fall in serum LH in old constant
estrous and pseudopregnant rats was significantly smaller than in the young rats, and 2 weeks after
estrogen treatment was terminated the rise in serum LH was significantly less in the old constant
estrous and pseudopregnant than in young rats. Serum LH in the old anestrous rats remained
undetectable.
Intact old constant estrous and pseudopregnant rats showed about the same serum FSH values
as young rats on the day of estrus, but exhibited a significantly smaller FSH rise after
ovariectomy and a smaller FSH fall after 8 days of EB administration than the young rats. Intact
old anestrous rats had as low serum FSH levels as young rats in diestrus, showed only a small rise in
serum FSH after ovariectomy and no change after estrogen injections. After estrogen treatment
was withdrawn, the rise in serum FSH in the old constant estrous and pseudopregnant rats was
significantly less than in the young rats, and showed no increase in the old anestrous rats. The
intact old constant estrous rats had 2 to 3 times more serum prolactin than young rats, and the
intact old pseudopregnant rats had about as much serum prolactin as young rats on the day of
estrus. Serum prolactin in intact old anestrous rats was twice as high as in old constant estrous rats
and 4 to 8 times greater than in old pseudopregnant or young rats. After ovariectomy, serum
prolactin decreased significantly in the old constant estrous and young rats, but not in the old
pseudopregnant or anestrous rats. EB administration increased serum prolactin in all categories of
rats, and fell after estrogen treatment was terminated. These observations suggest that the
hypothalamo-pituitar |
| doi_str_mv | 10.1095/biolreprod14.5.538 |
| format | Article |
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ovariectomy and during and after estradiol benzoate (EB) treatment in 4-5 month old young
mature female rats, in 22-24 month old constant estrous and pseudopregnant rats, and in 26-30
month old anestrous rats. Serum LH in intact old constant estrous rats was significantly higher
than in young rats on the day of estrus, about the same in intact old pseudopregnant rats as in
young rats in diestrus, and was undetectable in the old anestrous rats. By 7 weeks after
ovariectomy, serum LH rose about 26 fold in young rats, only about 3 fold in the old constant
estrous rats, about 14 fold in the old pseudopregnant rats, and remained unmeasurable in the old
anestrous rats. After daily EB injection for 8 days, the relative fall in serum LH in old constant
estrous and pseudopregnant rats was significantly smaller than in the young rats, and 2 weeks after
estrogen treatment was terminated the rise in serum LH was significantly less in the old constant
estrous and pseudopregnant than in young rats. Serum LH in the old anestrous rats remained
undetectable.
Intact old constant estrous and pseudopregnant rats showed about the same serum FSH values
as young rats on the day of estrus, but exhibited a significantly smaller FSH rise after
ovariectomy and a smaller FSH fall after 8 days of EB administration than the young rats. Intact
old anestrous rats had as low serum FSH levels as young rats in diestrus, showed only a small rise in
serum FSH after ovariectomy and no change after estrogen injections. After estrogen treatment
was withdrawn, the rise in serum FSH in the old constant estrous and pseudopregnant rats was
significantly less than in the young rats, and showed no increase in the old anestrous rats. The
intact old constant estrous rats had 2 to 3 times more serum prolactin than young rats, and the
intact old pseudopregnant rats had about as much serum prolactin as young rats on the day of
estrus. Serum prolactin in intact old anestrous rats was twice as high as in old constant estrous rats
and 4 to 8 times greater than in old pseudopregnant or young rats. After ovariectomy, serum
prolactin decreased significantly in the old constant estrous and young rats, but not in the old
pseudopregnant or anestrous rats. EB administration increased serum prolactin in all categories of
rats, and fell after estrogen treatment was terminated. These observations suggest that the
hypothalamo-pituitary system of old female rats has less capacity to secrete FSH and LH and more
capacity to secrete prolactin than young cycling female rats, and are believed to largely explain
why old female rats cease to cycle.</description><identifier>ISSN: 0006-3363</identifier><identifier>EISSN: 1529-7268</identifier><identifier>DOI: 10.1095/biolreprod14.5.538</identifier><identifier>PMID: 945081</identifier><language>eng</language><publisher>United States: Society for the Study of Reproduction</publisher><subject>Aging ; Anestrus ; Animals ; Body Weight ; Estrus ; Female ; Follicle Stimulating Hormone - blood ; Follicle Stimulating Hormone - metabolism ; Luteinizing Hormone - blood ; Luteinizing Hormone - metabolism ; Organ Size ; Ovary - anatomy & histology ; Pituitary Gland - anatomy & histology ; Pregnancy ; Prolactin - blood ; Prolactin - metabolism ; Pseudopregnancy ; Rats - physiology</subject><ispartof>Biology of reproduction, 1976-06, Vol.14 (5), p.538-543</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-c0aba4e71d4f27cf481dae56ae94ffd7cb59a56bda77fc15feb939a31d65a733</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/945081$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, H H</creatorcontrib><creatorcontrib>Marshall, S</creatorcontrib><creatorcontrib>Meites, J</creatorcontrib><title>Capacity of Old Versus Young Female Rats to Secrete LH, FSH and Prolactin</title><title>Biology of reproduction</title><addtitle>Biol Reprod</addtitle><description>Serum LH, FSH and prolactin levels were measured by radioimmunoassays before and after
ovariectomy and during and after estradiol benzoate (EB) treatment in 4-5 month old young
mature female rats, in 22-24 month old constant estrous and pseudopregnant rats, and in 26-30
month old anestrous rats. Serum LH in intact old constant estrous rats was significantly higher
than in young rats on the day of estrus, about the same in intact old pseudopregnant rats as in
young rats in diestrus, and was undetectable in the old anestrous rats. By 7 weeks after
ovariectomy, serum LH rose about 26 fold in young rats, only about 3 fold in the old constant
estrous rats, about 14 fold in the old pseudopregnant rats, and remained unmeasurable in the old
anestrous rats. After daily EB injection for 8 days, the relative fall in serum LH in old constant
estrous and pseudopregnant rats was significantly smaller than in the young rats, and 2 weeks after
estrogen treatment was terminated the rise in serum LH was significantly less in the old constant
estrous and pseudopregnant than in young rats. Serum LH in the old anestrous rats remained
undetectable.
Intact old constant estrous and pseudopregnant rats showed about the same serum FSH values
as young rats on the day of estrus, but exhibited a significantly smaller FSH rise after
ovariectomy and a smaller FSH fall after 8 days of EB administration than the young rats. Intact
old anestrous rats had as low serum FSH levels as young rats in diestrus, showed only a small rise in
serum FSH after ovariectomy and no change after estrogen injections. After estrogen treatment
was withdrawn, the rise in serum FSH in the old constant estrous and pseudopregnant rats was
significantly less than in the young rats, and showed no increase in the old anestrous rats. The
intact old constant estrous rats had 2 to 3 times more serum prolactin than young rats, and the
intact old pseudopregnant rats had about as much serum prolactin as young rats on the day of
estrus. Serum prolactin in intact old anestrous rats was twice as high as in old constant estrous rats
and 4 to 8 times greater than in old pseudopregnant or young rats. After ovariectomy, serum
prolactin decreased significantly in the old constant estrous and young rats, but not in the old
pseudopregnant or anestrous rats. EB administration increased serum prolactin in all categories of
rats, and fell after estrogen treatment was terminated. These observations suggest that the
hypothalamo-pituitary system of old female rats has less capacity to secrete FSH and LH and more
capacity to secrete prolactin than young cycling female rats, and are believed to largely explain
why old female rats cease to cycle.</description><subject>Aging</subject><subject>Anestrus</subject><subject>Animals</subject><subject>Body Weight</subject><subject>Estrus</subject><subject>Female</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Follicle Stimulating Hormone - metabolism</subject><subject>Luteinizing Hormone - blood</subject><subject>Luteinizing Hormone - metabolism</subject><subject>Organ Size</subject><subject>Ovary - anatomy & histology</subject><subject>Pituitary Gland - anatomy & histology</subject><subject>Pregnancy</subject><subject>Prolactin - blood</subject><subject>Prolactin - metabolism</subject><subject>Pseudopregnancy</subject><subject>Rats - physiology</subject><issn>0006-3363</issn><issn>1529-7268</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkF1LwzAUhoP4Nad_QLzIjV7ZmTRN017KcG4wmLgheBVOk5NZ6daZtIz9eysbw6tz8b7vA-ch5JazAWe5fCrKuvK48bXlyUAOpMhOSI_LOI9UnGanpMcYSyMhUnFJrkL4ZownIhYX5DxPJMt4j0yGsAFTNjtaOzqrLP1AH9pAP-t2vaQjXEGF9B2aQJuaztF4bJBOx490NB9TWFv65usKTFOur8mZgyrgzeH2yWL0shiOo-nsdTJ8nkZGKN5EhkEBCSpuExcr45KMW0CZAuaJc1aZQuYg08KCUs5w6bDIRQ6C21SCEqJPHvbY7uufFkOjV2UwWFWwxroNOhOJyBRXXTHeF42vQ_Do9MaXK_A7zZn-s6f_29NSd_a60d2B3hYrtMfJXlcX3-_jr3L5tS096tAJqrqy0Nvt9oj5BdtdeqI</recordid><startdate>197606</startdate><enddate>197606</enddate><creator>Huang, H H</creator><creator>Marshall, S</creator><creator>Meites, J</creator><general>Society for the Study of Reproduction</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197606</creationdate><title>Capacity of Old Versus Young Female Rats to Secrete LH, FSH and Prolactin</title><author>Huang, H H ; Marshall, S ; Meites, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-c0aba4e71d4f27cf481dae56ae94ffd7cb59a56bda77fc15feb939a31d65a733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>Aging</topic><topic>Anestrus</topic><topic>Animals</topic><topic>Body Weight</topic><topic>Estrus</topic><topic>Female</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Follicle Stimulating Hormone - metabolism</topic><topic>Luteinizing Hormone - blood</topic><topic>Luteinizing Hormone - metabolism</topic><topic>Organ Size</topic><topic>Ovary - anatomy & histology</topic><topic>Pituitary Gland - anatomy & histology</topic><topic>Pregnancy</topic><topic>Prolactin - blood</topic><topic>Prolactin - metabolism</topic><topic>Pseudopregnancy</topic><topic>Rats - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, H H</creatorcontrib><creatorcontrib>Marshall, S</creatorcontrib><creatorcontrib>Meites, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biology of reproduction</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, H H</au><au>Marshall, S</au><au>Meites, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Capacity of Old Versus Young Female Rats to Secrete LH, FSH and Prolactin</atitle><jtitle>Biology of reproduction</jtitle><addtitle>Biol Reprod</addtitle><date>1976-06</date><risdate>1976</risdate><volume>14</volume><issue>5</issue><spage>538</spage><epage>543</epage><pages>538-543</pages><issn>0006-3363</issn><eissn>1529-7268</eissn><abstract>Serum LH, FSH and prolactin levels were measured by radioimmunoassays before and after
ovariectomy and during and after estradiol benzoate (EB) treatment in 4-5 month old young
mature female rats, in 22-24 month old constant estrous and pseudopregnant rats, and in 26-30
month old anestrous rats. Serum LH in intact old constant estrous rats was significantly higher
than in young rats on the day of estrus, about the same in intact old pseudopregnant rats as in
young rats in diestrus, and was undetectable in the old anestrous rats. By 7 weeks after
ovariectomy, serum LH rose about 26 fold in young rats, only about 3 fold in the old constant
estrous rats, about 14 fold in the old pseudopregnant rats, and remained unmeasurable in the old
anestrous rats. After daily EB injection for 8 days, the relative fall in serum LH in old constant
estrous and pseudopregnant rats was significantly smaller than in the young rats, and 2 weeks after
estrogen treatment was terminated the rise in serum LH was significantly less in the old constant
estrous and pseudopregnant than in young rats. Serum LH in the old anestrous rats remained
undetectable.
Intact old constant estrous and pseudopregnant rats showed about the same serum FSH values
as young rats on the day of estrus, but exhibited a significantly smaller FSH rise after
ovariectomy and a smaller FSH fall after 8 days of EB administration than the young rats. Intact
old anestrous rats had as low serum FSH levels as young rats in diestrus, showed only a small rise in
serum FSH after ovariectomy and no change after estrogen injections. After estrogen treatment
was withdrawn, the rise in serum FSH in the old constant estrous and pseudopregnant rats was
significantly less than in the young rats, and showed no increase in the old anestrous rats. The
intact old constant estrous rats had 2 to 3 times more serum prolactin than young rats, and the
intact old pseudopregnant rats had about as much serum prolactin as young rats on the day of
estrus. Serum prolactin in intact old anestrous rats was twice as high as in old constant estrous rats
and 4 to 8 times greater than in old pseudopregnant or young rats. After ovariectomy, serum
prolactin decreased significantly in the old constant estrous and young rats, but not in the old
pseudopregnant or anestrous rats. EB administration increased serum prolactin in all categories of
rats, and fell after estrogen treatment was terminated. These observations suggest that the
hypothalamo-pituitary system of old female rats has less capacity to secrete FSH and LH and more
capacity to secrete prolactin than young cycling female rats, and are believed to largely explain
why old female rats cease to cycle.</abstract><cop>United States</cop><pub>Society for the Study of Reproduction</pub><pmid>945081</pmid><doi>10.1095/biolreprod14.5.538</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-3363 |
| ispartof | Biology of reproduction, 1976-06, Vol.14 (5), p.538-543 |
| issn | 0006-3363 1529-7268 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83438717 |
| source | MEDLINE; Free E-Journal (出版社公開部分のみ） |
| subjects | Aging Anestrus Animals Body Weight Estrus Female Follicle Stimulating Hormone - blood Follicle Stimulating Hormone - metabolism Luteinizing Hormone - blood Luteinizing Hormone - metabolism Organ Size Ovary - anatomy & histology Pituitary Gland - anatomy & histology Pregnancy Prolactin - blood Prolactin - metabolism Pseudopregnancy Rats - physiology |
| title | Capacity of Old Versus Young Female Rats to Secrete LH, FSH and Prolactin |
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