DNA turnover: Evidence from studies of steady-state bacterial populations
Since the work of Hershey (1954) most biologists have regarded DNA pools of bacterial cells as stable or conservative. Nonetheless, turnover was invoked as a possible explanation of mutation in non-replicating bacterial cells (Ryan, 1949) and in spheroplasts ( Ryan et al. , 1963 ). It also could acc...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1964-06, Vol.16 (2), p.124-128 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Contois, D.E. Seymour, W.F.K. |
| description | Since the work of
Hershey (1954) most biologists have regarded DNA pools of bacterial cells as stable or conservative. Nonetheless, turnover was invoked as a possible explanation of mutation in non-replicating bacterial cells (Ryan, 1949) and in spheroplasts (
Ryan
et
al.
, 1963
). It also could account for observations of mutation rates independent of growth rates in slowly growing cultures of
Escherichia
coli
(
Novick & Szilard, 1950;
Fox, 1955). Results of recent studies suggest DNA turnover in cultures of primary human amnion cells (
Chang & Vetrovs, 1963), mouse fibroblasts (
Thomson
et
al.
, 1957
), and bacteria (
Theil & Zamenhof, 1963). We have obtained evidence of DNA turnover from studies of carbon-flux through steady-state cultures of
Aerobacter
aerogenes
under conditions of nitrogen limitation. |
| doi_str_mv | 10.1016/0006-291X(64)90348-1 |
| format | Article |
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Hershey (1954) most biologists have regarded DNA pools of bacterial cells as stable or conservative. Nonetheless, turnover was invoked as a possible explanation of mutation in non-replicating bacterial cells (Ryan, 1949) and in spheroplasts (
Ryan
et
al.
, 1963
). It also could account for observations of mutation rates independent of growth rates in slowly growing cultures of
Escherichia
coli
(
Novick & Szilard, 1950;
Fox, 1955). Results of recent studies suggest DNA turnover in cultures of primary human amnion cells (
Chang & Vetrovs, 1963), mouse fibroblasts (
Thomson
et
al.
, 1957
), and bacteria (
Theil & Zamenhof, 1963). We have obtained evidence of DNA turnover from studies of carbon-flux through steady-state cultures of
Aerobacter
aerogenes
under conditions of nitrogen limitation.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/0006-291X(64)90348-1</identifier><identifier>PMID: 5871800</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Bacterial Proteins - metabolism ; Carbon Isotopes - metabolism ; DNA, Bacterial - metabolism ; Enterobacter - metabolism</subject><ispartof>Biochemical and biophysical research communications, 1964-06, Vol.16 (2), p.124-128</ispartof><rights>1964</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-694ba66aa483ac7b6243f32fb147bcc9caf4f239f921fb65523d51dcb9dda5343</citedby><cites>FETCH-LOGICAL-c357t-694ba66aa483ac7b6243f32fb147bcc9caf4f239f921fb65523d51dcb9dda5343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-291X(64)90348-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5871800$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Contois, D.E.</creatorcontrib><creatorcontrib>Seymour, W.F.K.</creatorcontrib><title>DNA turnover: Evidence from studies of steady-state bacterial populations</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Since the work of
Hershey (1954) most biologists have regarded DNA pools of bacterial cells as stable or conservative. Nonetheless, turnover was invoked as a possible explanation of mutation in non-replicating bacterial cells (Ryan, 1949) and in spheroplasts (
Ryan
et
al.
, 1963
). It also could account for observations of mutation rates independent of growth rates in slowly growing cultures of
Escherichia
coli
(
Novick & Szilard, 1950;
Fox, 1955). Results of recent studies suggest DNA turnover in cultures of primary human amnion cells (
Chang & Vetrovs, 1963), mouse fibroblasts (
Thomson
et
al.
, 1957
), and bacteria (
Theil & Zamenhof, 1963). We have obtained evidence of DNA turnover from studies of carbon-flux through steady-state cultures of
Aerobacter
aerogenes
under conditions of nitrogen limitation.</description><subject>Bacterial Proteins - metabolism</subject><subject>Carbon Isotopes - metabolism</subject><subject>DNA, Bacterial - metabolism</subject><subject>Enterobacter - metabolism</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1964</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF9LwzAUxYMoc06_gUKfRB-qSZOmjQ_CmFMHQ18UfAtp_kCkbWqSDvbtbd3Yo0_3wj3nXM4PgEsE7xBE9B5CSNOMoa8bSm4ZxKRM0RGYIshgmiFIjsH0IDkFZyF8Q4gQoWwCJnlZoBLCKVg9vc2T2PvWbbR_SJYbq3QrdWK8a5IQe2V1SJwZVi3UNg1RRJ1UQkbtraiTznV9LaJ1bTgHJ0bUQV_s5wx8Pi8_Fq_p-v1ltZivU4nzIqaUkUpQKgQpsZBFRTOCDc5MhUhRScmkMMRkmBmWIVPRPM-wypGSFVNK5JjgGbje5Xbe_fQ6RN7YIHVdi1a7PvASk4wO3QYh2QmldyF4bXjnbSP8liPIR4J8xMNHPJwS_keQo8F2tc_vq0arg2mPbLg_7u56KLmx2vMg7chMWa9l5MrZ_x_8Ar0lgHY</recordid><startdate>19640601</startdate><enddate>19640601</enddate><creator>Contois, D.E.</creator><creator>Seymour, W.F.K.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19640601</creationdate><title>DNA turnover: Evidence from studies of steady-state bacterial populations</title><author>Contois, D.E. ; Seymour, W.F.K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-694ba66aa483ac7b6243f32fb147bcc9caf4f239f921fb65523d51dcb9dda5343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1964</creationdate><topic>Bacterial Proteins - metabolism</topic><topic>Carbon Isotopes - metabolism</topic><topic>DNA, Bacterial - metabolism</topic><topic>Enterobacter - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Contois, D.E.</creatorcontrib><creatorcontrib>Seymour, W.F.K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Contois, D.E.</au><au>Seymour, W.F.K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DNA turnover: Evidence from studies of steady-state bacterial populations</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1964-06-01</date><risdate>1964</risdate><volume>16</volume><issue>2</issue><spage>124</spage><epage>128</epage><pages>124-128</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Since the work of
Hershey (1954) most biologists have regarded DNA pools of bacterial cells as stable or conservative. Nonetheless, turnover was invoked as a possible explanation of mutation in non-replicating bacterial cells (Ryan, 1949) and in spheroplasts (
Ryan
et
al.
, 1963
). It also could account for observations of mutation rates independent of growth rates in slowly growing cultures of
Escherichia
coli
(
Novick & Szilard, 1950;
Fox, 1955). Results of recent studies suggest DNA turnover in cultures of primary human amnion cells (
Chang & Vetrovs, 1963), mouse fibroblasts (
Thomson
et
al.
, 1957
), and bacteria (
Theil & Zamenhof, 1963). We have obtained evidence of DNA turnover from studies of carbon-flux through steady-state cultures of
Aerobacter
aerogenes
under conditions of nitrogen limitation.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>5871800</pmid><doi>10.1016/0006-291X(64)90348-1</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Biochemical and biophysical research communications, 1964-06, Vol.16 (2), p.124-128 |
| issn | 0006-291X 1090-2104 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83426800 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Bacterial Proteins - metabolism Carbon Isotopes - metabolism DNA, Bacterial - metabolism Enterobacter - metabolism |
| title | DNA turnover: Evidence from studies of steady-state bacterial populations |
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