Exaggerated avoidance of novel stimulation in rats partially recovered from central norepinephrine damage
Rats in which central norepinephrine lesions are made with 6-OHDA and a recovery period allowed show a behavioral syndrome distinct from controls, from rats with more extensive norepinephrine damage (lesioned with 6-OHDA, allowed to recover, and relesioned), and from rats with general depletion of s...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 1976-03, Vol.4 (3), p.343-346 |
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| container_end_page | 346 |
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| container_title | Pharmacology, biochemistry and behavior |
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| creator | Bresler, David E. Diaz, Jaime Ellison, Gaylord |
| description | Rats in which central norepinephrine lesions are made with 6-OHDA and a recovery period allowed show a behavioral syndrome distinct from controls, from rats with more extensive norepinephrine damage (lesioned with 6-OHDA, allowed to recover, and relesioned), and from rats with general depletion of serotonin (chronic PCPA). These rats administered central 6-OHDA injections and then allowed a recovery period rear less in open field than all other groups and are characterized by an exaggerated avoidance of novel visual stimulation in light onset and light escape tests. It is proposed that this reflects the hyperresponsivity of partially repaired, supersensitive norepinephrine circuitry to novel or intense stimulation. |
| doi_str_mv | 10.1016/0091-3057(76)90253-7 |
| format | Article |
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These rats administered central 6-OHDA injections and then allowed a recovery period rear less in open field than all other groups and are characterized by an exaggerated avoidance of novel visual stimulation in light onset and light escape tests. It is proposed that this reflects the hyperresponsivity of partially repaired, supersensitive norepinephrine circuitry to novel or intense stimulation.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/0091-3057(76)90253-7</identifier><identifier>PMID: 935205</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>6-OHDA ; Animals ; Attentional deficits ; Biogenic Amines - analysis ; Brain Chemistry - drug effects ; Electroshock ; Escape Reaction - drug effects ; Hydroxydopamines - pharmacology ; Hyperkinesis ; Male ; NE lesions ; Norepinephrine - physiology ; Photic Stimulation ; Rats ; Recovery and supersensitivity ; Time Factors</subject><ispartof>Pharmacology, biochemistry and behavior, 1976-03, Vol.4 (3), p.343-346</ispartof><rights>1976</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-d84b378a6c9ab7dc55423e71109511bcfd9b9cd4fb46291e1e5e8703276ed3123</citedby><cites>FETCH-LOGICAL-c356t-d84b378a6c9ab7dc55423e71109511bcfd9b9cd4fb46291e1e5e8703276ed3123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0091-3057(76)90253-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/935205$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bresler, David E.</creatorcontrib><creatorcontrib>Diaz, Jaime</creatorcontrib><creatorcontrib>Ellison, Gaylord</creatorcontrib><title>Exaggerated avoidance of novel stimulation in rats partially recovered from central norepinephrine damage</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>Rats in which central norepinephrine lesions are made with 6-OHDA and a recovery period allowed show a behavioral syndrome distinct from controls, from rats with more extensive norepinephrine damage (lesioned with 6-OHDA, allowed to recover, and relesioned), and from rats with general depletion of serotonin (chronic PCPA). These rats administered central 6-OHDA injections and then allowed a recovery period rear less in open field than all other groups and are characterized by an exaggerated avoidance of novel visual stimulation in light onset and light escape tests. It is proposed that this reflects the hyperresponsivity of partially repaired, supersensitive norepinephrine circuitry to novel or intense stimulation.</description><subject>6-OHDA</subject><subject>Animals</subject><subject>Attentional deficits</subject><subject>Biogenic Amines - analysis</subject><subject>Brain Chemistry - drug effects</subject><subject>Electroshock</subject><subject>Escape Reaction - drug effects</subject><subject>Hydroxydopamines - pharmacology</subject><subject>Hyperkinesis</subject><subject>Male</subject><subject>NE lesions</subject><subject>Norepinephrine - physiology</subject><subject>Photic Stimulation</subject><subject>Rats</subject><subject>Recovery and supersensitivity</subject><subject>Time Factors</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQhi3EVyn8gw6eEAwBO47jZEFCVfmQKrHAbDn2pRglcbDTiv57XFJ1ZLkb7nlf6R6EZpTcUULze0JKmjDCxY3Ib0uScpaIIzShhWAJp0Ico8kBOUcXIXwRQrI0F2fotGQ8JXyC7OJHrVbg1QAGq42zRnUasKtx5zbQ4DDYdt2owboO2w5HLuBe-cGqptliDzpSPkZr71qsoRu8amLUQ2876D99nNioVq3gEp3Uqglwtd9T9PG0eJ-_JMu359f54zLRjOdDYoqsYqJQuS5VJYzmPEsZCEpJySmtdG3KqtQmq6ssT0sKFDgUgrBU5GAYTdkUXY-9vXffawiDbG3Q0DSqA7cOsmBZSguaRTAbQe1dCB5q2XvbKr-VlMidYLmzJ3f2pMjln2ApYmy2719XLZhDaDQazw_jGeKPGwteBm0hOjU22hqkcfb__l8bu4vT</recordid><startdate>197603</startdate><enddate>197603</enddate><creator>Bresler, David E.</creator><creator>Diaz, Jaime</creator><creator>Ellison, Gaylord</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197603</creationdate><title>Exaggerated avoidance of novel stimulation in rats partially recovered from central norepinephrine damage</title><author>Bresler, David E. ; Diaz, Jaime ; Ellison, Gaylord</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-d84b378a6c9ab7dc55423e71109511bcfd9b9cd4fb46291e1e5e8703276ed3123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>6-OHDA</topic><topic>Animals</topic><topic>Attentional deficits</topic><topic>Biogenic Amines - analysis</topic><topic>Brain Chemistry - drug effects</topic><topic>Electroshock</topic><topic>Escape Reaction - drug effects</topic><topic>Hydroxydopamines - pharmacology</topic><topic>Hyperkinesis</topic><topic>Male</topic><topic>NE lesions</topic><topic>Norepinephrine - physiology</topic><topic>Photic Stimulation</topic><topic>Rats</topic><topic>Recovery and supersensitivity</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bresler, David E.</creatorcontrib><creatorcontrib>Diaz, Jaime</creatorcontrib><creatorcontrib>Ellison, Gaylord</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bresler, David E.</au><au>Diaz, Jaime</au><au>Ellison, Gaylord</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exaggerated avoidance of novel stimulation in rats partially recovered from central norepinephrine damage</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>1976-03</date><risdate>1976</risdate><volume>4</volume><issue>3</issue><spage>343</spage><epage>346</epage><pages>343-346</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><abstract>Rats in which central norepinephrine lesions are made with 6-OHDA and a recovery period allowed show a behavioral syndrome distinct from controls, from rats with more extensive norepinephrine damage (lesioned with 6-OHDA, allowed to recover, and relesioned), and from rats with general depletion of serotonin (chronic PCPA). These rats administered central 6-OHDA injections and then allowed a recovery period rear less in open field than all other groups and are characterized by an exaggerated avoidance of novel visual stimulation in light onset and light escape tests. It is proposed that this reflects the hyperresponsivity of partially repaired, supersensitive norepinephrine circuitry to novel or intense stimulation.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>935205</pmid><doi>10.1016/0091-3057(76)90253-7</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-3057 |
| ispartof | Pharmacology, biochemistry and behavior, 1976-03, Vol.4 (3), p.343-346 |
| issn | 0091-3057 1873-5177 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83421814 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | 6-OHDA Animals Attentional deficits Biogenic Amines - analysis Brain Chemistry - drug effects Electroshock Escape Reaction - drug effects Hydroxydopamines - pharmacology Hyperkinesis Male NE lesions Norepinephrine - physiology Photic Stimulation Rats Recovery and supersensitivity Time Factors |
| title | Exaggerated avoidance of novel stimulation in rats partially recovered from central norepinephrine damage |
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