Rapid determination of theophylline in human plasma by high-pressure liquid chromatography
A rapid, specific, high-pressure liquid chromatographic method for the determination of theophylline in plasma was developed. The procedure is fast enough (21min from receipt of blood to reporting value) to be used for emergency determinations. The sensitivity, precision, and accuracy are sufficient...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1976-06, Vol.65 (6), p.865-868 |
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| Hauptverfasser: | , |
| Format: | Artikel |
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| container_end_page | 868 |
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| container_issue | 6 |
| container_start_page | 865 |
| container_title | Journal of pharmaceutical sciences |
| container_volume | 65 |
| creator | Weddle, Orville H. Mason, William D. |
| description | A rapid, specific, high-pressure liquid chromatographic method for the determination of theophylline in plasma was developed. The procedure is fast enough (21min from receipt of blood to reporting value) to be used for emergency determinations. The sensitivity, precision, and accuracy are sufficient for routine monitoring of therapeutic levels in patients. The assay is specific enough to be valid in the presence of caffeine and theobromine. Metabolites of theophylline as well as a number of drugs do not interfere with the assay. |
| doi_str_mv | 10.1002/jps.2600650616 |
| format | Article |
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The procedure is fast enough (21min from receipt of blood to reporting value) to be used for emergency determinations. The sensitivity, precision, and accuracy are sufficient for routine monitoring of therapeutic levels in patients. The assay is specific enough to be valid in the presence of caffeine and theobromine. Metabolites of theophylline as well as a number of drugs do not interfere with the assay.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600650616</identifier><identifier>PMID: 932972</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Chromatography, High Pressure Liquid ; high-pressure liquid chromatographic analysis ; High-pressure liquid chromatography-analysis ; High-pressure liquid chromatography—analysis, theophylline, plasma ; plasma ; Relaxants ; Relaxants, smooth muscle—theophylline, high-pressure liquid chromatographic analysis, plasma ; smooth muscle-theophylline ; theophylline ; Theophylline - blood ; Theophylline-high-pressure liquid chromatographic analysis ; Theophylline—high-pressure liquid chromatographic analysis, plasma</subject><ispartof>Journal of pharmaceutical sciences, 1976-06, Vol.65 (6), p.865-868</ispartof><rights>1976 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1976 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4266-40df05ef8ff4f6c758544bad5c8350811b85d9a3369920165c6a47263deba97f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600650616$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600650616$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/932972$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weddle, Orville H.</creatorcontrib><creatorcontrib>Mason, William D.</creatorcontrib><title>Rapid determination of theophylline in human plasma by high-pressure liquid chromatography</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>A rapid, specific, high-pressure liquid chromatographic method for the determination of theophylline in plasma was developed. The procedure is fast enough (21min from receipt of blood to reporting value) to be used for emergency determinations. The sensitivity, precision, and accuracy are sufficient for routine monitoring of therapeutic levels in patients. The assay is specific enough to be valid in the presence of caffeine and theobromine. Metabolites of theophylline as well as a number of drugs do not interfere with the assay.</description><subject>Chromatography, High Pressure Liquid</subject><subject>high-pressure liquid chromatographic analysis</subject><subject>High-pressure liquid chromatography-analysis</subject><subject>High-pressure liquid chromatography—analysis, theophylline, plasma</subject><subject>plasma</subject><subject>Relaxants</subject><subject>Relaxants, smooth muscle—theophylline, high-pressure liquid chromatographic analysis, plasma</subject><subject>smooth muscle-theophylline</subject><subject>theophylline</subject><subject>Theophylline - blood</subject><subject>Theophylline-high-pressure liquid chromatographic analysis</subject><subject>Theophylline—high-pressure liquid chromatographic analysis, plasma</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi3E17Jw5cTBJ25Z_BE7yREVWgqrAgWExMVy7HHjksSpnUD332OUqogD4jJzmOd9pXkQekrJjhLCXlxOacckIVIQSeUdtKGCkUISWt1FmwywgouyeYgepXRJMkaEeIDuN5w1Fdugb-d68hZbmCEOftSzDyMODs8dhKk79L0fAfsRd8ugRzz1Og0atwfc-YuumCKktETAvb9acovpYhj0HC6iztnH6J7TfYInN3uLvhy__nz0pti_Pzk9erkvTMmkLEpiHRHgaudKJ00lalGWrbbC1FyQmtK2FrbRnMumYYRKYaQuKya5hVY3leNb9HztnWK4WiDNavDJQN_rEcKSVM15U7M8t2i3giaGlCI4NUU_6HhQlKjfLlV2qf64zIFnN81LO4C9xVd5-dys55--h8N_ytTbD5_-qi7WrE8zXN9mdfyuZMUrob6enSj57uMrsj8_U8eZr1cesskfHqJKxsNowPoIZlY2-H998Qu4eaL2</recordid><startdate>197606</startdate><enddate>197606</enddate><creator>Weddle, Orville H.</creator><creator>Mason, William D.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197606</creationdate><title>Rapid determination of theophylline in human plasma by high-pressure liquid chromatography</title><author>Weddle, Orville H. ; Mason, William D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4266-40df05ef8ff4f6c758544bad5c8350811b85d9a3369920165c6a47263deba97f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>Chromatography, High Pressure Liquid</topic><topic>high-pressure liquid chromatographic analysis</topic><topic>High-pressure liquid chromatography-analysis</topic><topic>High-pressure liquid chromatography—analysis, theophylline, plasma</topic><topic>plasma</topic><topic>Relaxants</topic><topic>Relaxants, smooth muscle—theophylline, high-pressure liquid chromatographic analysis, plasma</topic><topic>smooth muscle-theophylline</topic><topic>theophylline</topic><topic>Theophylline - blood</topic><topic>Theophylline-high-pressure liquid chromatographic analysis</topic><topic>Theophylline—high-pressure liquid chromatographic analysis, plasma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weddle, Orville H.</creatorcontrib><creatorcontrib>Mason, William D.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weddle, Orville H.</au><au>Mason, William D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rapid determination of theophylline in human plasma by high-pressure liquid chromatography</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1976-06</date><risdate>1976</risdate><volume>65</volume><issue>6</issue><spage>865</spage><epage>868</epage><pages>865-868</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>A rapid, specific, high-pressure liquid chromatographic method for the determination of theophylline in plasma was developed. The procedure is fast enough (21min from receipt of blood to reporting value) to be used for emergency determinations. The sensitivity, precision, and accuracy are sufficient for routine monitoring of therapeutic levels in patients. The assay is specific enough to be valid in the presence of caffeine and theobromine. Metabolites of theophylline as well as a number of drugs do not interfere with the assay.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>932972</pmid><doi>10.1002/jps.2600650616</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1976-06, Vol.65 (6), p.865-868 |
| issn | 0022-3549 1520-6017 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83398283 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Chromatography, High Pressure Liquid high-pressure liquid chromatographic analysis High-pressure liquid chromatography-analysis High-pressure liquid chromatography—analysis, theophylline, plasma plasma Relaxants Relaxants, smooth muscle—theophylline, high-pressure liquid chromatographic analysis, plasma smooth muscle-theophylline theophylline Theophylline - blood Theophylline-high-pressure liquid chromatographic analysis Theophylline—high-pressure liquid chromatographic analysis, plasma |
| title | Rapid determination of theophylline in human plasma by high-pressure liquid chromatography |
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