Hypocholesterolemic agents IV: inhibition of beta-hydroxy-beta-methyglutaryl coenzyme A reductase by arylalkenyl and arylepoxy hydrogen succinates and glutarates

Two series of half acid esters of succinic and glutaric acids were synthesized and assayed for inhibition of rat liver beta-hydroxy-beta-methylglutaryl coenzyme A reductase. Irreversible inhibition was studied by incorporation of a potential alkylating group (the epoxide function) into the side chai...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1976-05, Vol.65 (5), p.724-727
Hauptverfasser:	Boots, M R, Marecki, P E, Boots, S G, Guyer, K E
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Oxidoreductases - antagonists & inhibitors Alkenes - chemical synthesis Alkenes - pharmacology Animals Anticholesteremic Agents - pharmacology Chemical Phenomena Chemistry Epoxy Compounds - chemical synthesis Epoxy Compounds - pharmacology Ethers, Cyclic - pharmacology Glutarates - chemical synthesis Glutarates - pharmacology Hydroxymethylglutaryl-CoA Reductase Inhibitors In Vitro Techniques Microsomes, Liver - enzymology Rats Succinates - chemical synthesis Succinates - pharmacology
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