Effects of benzydamine on the lipolytic system of fat cells

Benzydamine dose-dependently increased cyclic 3',5'-AMP levels in isolated fat cells and competitively inhibited phosphodiesterase activity ( K i = 1.1 mM). ATP levels of isolated cells and cyclic 3',5'-AMP-dependent protein kinase activity were not affected. However, benzydamine...

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Veröffentlicht in:	Biochemical pharmacology 1976-02, Vol.25 (3), p.299-303
Hauptverfasser:	Dinnendahl, Volker, Peters, Hans D., Schönhöfer, Peter S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Adipose Tissue - cytology Adipose Tissue - drug effects Adipose Tissue - metabolism Animals Benzydamine - pharmacology Cyclic AMP - metabolism In Vitro Techniques Lipase - metabolism Lipid Metabolism Male Phosphoric Diester Hydrolases - metabolism Protein Kinases - metabolism Pyrazoles - pharmacology Rats Time Factors
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Zusammenfassung:	Benzydamine dose-dependently increased cyclic 3',5'-AMP levels in isolated fat cells and competitively inhibited phosphodiesterase activity ( K i = 1.1 mM). ATP levels of isolated cells and cyclic 3',5'-AMP-dependent protein kinase activity were not affected. However, benzydamine caused a dose-dependent inhibition of lipolysis in isolated fat cells stimulated by norepinephrine or dibutyryl cyclic 3',5'-AMP. The enhancement of cyclic 3',5'-AMP formation may be due to the local anaesthetic properties of benzydamine. The antilipolytic effect appears to result from the direct inhibition of hormone sensitive triglyceride lipase.
ISSN:	0006-2952 1873-2968
DOI:	10.1016/0006-2952(76)90218-5