Proteins dealing with N-ethylmaleimide inhibition of pig heart mitochondrial phosphate transport system
Our data clearly demonstrate that protective effect of phosphate and protective effect of mersalyl against NEM-inhibition of phosphate transport act at the level of two kinds of proteins. (1)Two major components are phosphate and nigericin NEM sensitive. According to our previous data [13] it has be...
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| Veröffentlicht in: | FEBS letters 1976-05, Vol.65 (1), p.1-7 |
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| creator | Briand, Yves Touraille, Sylvie Debise, Roger Durand, Roger |
| description | Our data clearly demonstrate that protective effect of phosphate and protective effect of mersalyl against NEM-inhibition of phosphate transport act at the level of two kinds of proteins. (1)Two major components are phosphate and nigericin NEM sensitive. According to our previous data [13] it has been also demonstrated that these two proteins components are valinomycin NEM sensitive (results not shown here) suggesting a relationship between these proteins and the energy linked proton translocation process. Relationships between these proteins and the phosphate translocation process are not evident and are under further investigations. (2) Two other insoluble major components localised at the level of the subparticular fraction are mersalyl NEM sensitive. We can suggest that these proteins are implicated in the translocation of phosphate in pig heart mitochondria. |
| doi_str_mv | 10.1016/0014-5793(76)80608-4 |
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(1)Two major components are phosphate and nigericin NEM sensitive. According to our previous data [13] it has been also demonstrated that these two proteins components are valinomycin NEM sensitive (results not shown here) suggesting a relationship between these proteins and the energy linked proton translocation process. Relationships between these proteins and the phosphate translocation process are not evident and are under further investigations. (2) Two other insoluble major components localised at the level of the subparticular fraction are mersalyl NEM sensitive. We can suggest that these proteins are implicated in the translocation of phosphate in pig heart mitochondria.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/0014-5793(76)80608-4</identifier><identifier>PMID: 1278401</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>6,6′-dithionicotinic acid ; Animals ; Biological Transport - drug effects ; CPDS ; Ethylmaleimide - pharmacology ; Mersalyl - pharmacology ; Mitochondria, Muscle - analysis ; Mitochondria, Muscle - metabolism ; Muscle Proteins - analysis ; Muscle Proteins - metabolism ; Myocardium - ultrastructure ; N,N,N′,N′,-tetramethylenediamine ; N-ethylmeleimide ; NEM ; NIG ; nigericin ; Nigericin - pharmacology ; p-MB ; parachloromercuribenzoate ; Phosphates - metabolism ; Phosphates - pharmacology ; SDS ; sodium dodecyl sulfate ; Structure-Activity Relationship ; Swine ; TCA ; TEMED ; Trichloracetic acid ; Tris ; Tris (hydroxymethyl) aminomethane</subject><ispartof>FEBS letters, 1976-05, Vol.65 (1), p.1-7</ispartof><rights>1976</rights><rights>FEBS Letters 65 (1976) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4664-1bf2b453360a5670b4f4c959b36e90180cac1bc329b1f5b313f07328f54b1b9b3</citedby><cites>FETCH-LOGICAL-c4664-1bf2b453360a5670b4f4c959b36e90180cac1bc329b1f5b313f07328f54b1b9b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0014-5793(76)80608-4$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1278401$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Briand, Yves</creatorcontrib><creatorcontrib>Touraille, Sylvie</creatorcontrib><creatorcontrib>Debise, Roger</creatorcontrib><creatorcontrib>Durand, Roger</creatorcontrib><title>Proteins dealing with N-ethylmaleimide inhibition of pig heart mitochondrial phosphate transport system</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>Our data clearly demonstrate that protective effect of phosphate and protective effect of mersalyl against NEM-inhibition of phosphate transport act at the level of two kinds of proteins. (1)Two major components are phosphate and nigericin NEM sensitive. According to our previous data [13] it has been also demonstrated that these two proteins components are valinomycin NEM sensitive (results not shown here) suggesting a relationship between these proteins and the energy linked proton translocation process. Relationships between these proteins and the phosphate translocation process are not evident and are under further investigations. (2) Two other insoluble major components localised at the level of the subparticular fraction are mersalyl NEM sensitive. We can suggest that these proteins are implicated in the translocation of phosphate in pig heart mitochondria.</description><subject>6,6′-dithionicotinic acid</subject><subject>Animals</subject><subject>Biological Transport - drug effects</subject><subject>CPDS</subject><subject>Ethylmaleimide - pharmacology</subject><subject>Mersalyl - pharmacology</subject><subject>Mitochondria, Muscle - analysis</subject><subject>Mitochondria, Muscle - metabolism</subject><subject>Muscle Proteins - analysis</subject><subject>Muscle Proteins - metabolism</subject><subject>Myocardium - ultrastructure</subject><subject>N,N,N′,N′,-tetramethylenediamine</subject><subject>N-ethylmeleimide</subject><subject>NEM</subject><subject>NIG</subject><subject>nigericin</subject><subject>Nigericin - pharmacology</subject><subject>p-MB</subject><subject>parachloromercuribenzoate</subject><subject>Phosphates - metabolism</subject><subject>Phosphates - pharmacology</subject><subject>SDS</subject><subject>sodium dodecyl sulfate</subject><subject>Structure-Activity Relationship</subject><subject>Swine</subject><subject>TCA</subject><subject>TEMED</subject><subject>Trichloracetic acid</subject><subject>Tris</subject><subject>Tris (hydroxymethyl) aminomethane</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEFv1DAQhS0EKtvCPwDJJwSHgB07jnNBKlW3IFXAAc6W7Uw2g5I42F6q_fckTQU3xGk08968GX2EvODsLWdcvWOMy6KqG_G6Vm80U0wX8hHZcV2LQkilH5PdH8tTcp7SD7b0mjdn5IyXtZaM78jhawwZcEq0BTvgdKB3mHv6uYDcn4bRDoAjtkBx6tFhxjDR0NEZD7QHGzMdMQffh6mNaAc69yHNvc1Ac7RTmsPiSKeUYXxGnnR2SPD8oV6Q7_vrb1cfi9svN5-uLm8LL5WSBXdd6WQlhGK2UjVzspO-qRonFDTL88xbz50XZeN4VznBRcdqUequko67xXZBXm25cww_j5CyGTF5GAY7QTgmo4XQVaXlYpSb0ceQUoTOzBFHG0-GM7PyNSs8s8IztTL3fM269vIh_-hGaP8ubUAXfb_pdzjA6b8yzf76Q7kK67xW99P10PstCBZavxCiSR5h8tBiBJ9NG_Dfn_4GVhKefw</recordid><startdate>19760515</startdate><enddate>19760515</enddate><creator>Briand, Yves</creator><creator>Touraille, Sylvie</creator><creator>Debise, Roger</creator><creator>Durand, Roger</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19760515</creationdate><title>Proteins dealing with N-ethylmaleimide inhibition of pig heart mitochondrial phosphate transport system</title><author>Briand, Yves ; Touraille, Sylvie ; Debise, Roger ; Durand, Roger</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4664-1bf2b453360a5670b4f4c959b36e90180cac1bc329b1f5b313f07328f54b1b9b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>6,6′-dithionicotinic acid</topic><topic>Animals</topic><topic>Biological Transport - drug effects</topic><topic>CPDS</topic><topic>Ethylmaleimide - pharmacology</topic><topic>Mersalyl - pharmacology</topic><topic>Mitochondria, Muscle - analysis</topic><topic>Mitochondria, Muscle - metabolism</topic><topic>Muscle Proteins - analysis</topic><topic>Muscle Proteins - metabolism</topic><topic>Myocardium - ultrastructure</topic><topic>N,N,N′,N′,-tetramethylenediamine</topic><topic>N-ethylmeleimide</topic><topic>NEM</topic><topic>NIG</topic><topic>nigericin</topic><topic>Nigericin - pharmacology</topic><topic>p-MB</topic><topic>parachloromercuribenzoate</topic><topic>Phosphates - metabolism</topic><topic>Phosphates - pharmacology</topic><topic>SDS</topic><topic>sodium dodecyl sulfate</topic><topic>Structure-Activity Relationship</topic><topic>Swine</topic><topic>TCA</topic><topic>TEMED</topic><topic>Trichloracetic acid</topic><topic>Tris</topic><topic>Tris (hydroxymethyl) aminomethane</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Briand, Yves</creatorcontrib><creatorcontrib>Touraille, Sylvie</creatorcontrib><creatorcontrib>Debise, Roger</creatorcontrib><creatorcontrib>Durand, Roger</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Briand, Yves</au><au>Touraille, Sylvie</au><au>Debise, Roger</au><au>Durand, Roger</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proteins dealing with N-ethylmaleimide inhibition of pig heart mitochondrial phosphate transport system</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1976-05-15</date><risdate>1976</risdate><volume>65</volume><issue>1</issue><spage>1</spage><epage>7</epage><pages>1-7</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>Our data clearly demonstrate that protective effect of phosphate and protective effect of mersalyl against NEM-inhibition of phosphate transport act at the level of two kinds of proteins. (1)Two major components are phosphate and nigericin NEM sensitive. According to our previous data [13] it has been also demonstrated that these two proteins components are valinomycin NEM sensitive (results not shown here) suggesting a relationship between these proteins and the energy linked proton translocation process. Relationships between these proteins and the phosphate translocation process are not evident and are under further investigations. (2) Two other insoluble major components localised at the level of the subparticular fraction are mersalyl NEM sensitive. We can suggest that these proteins are implicated in the translocation of phosphate in pig heart mitochondria.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>1278401</pmid><doi>10.1016/0014-5793(76)80608-4</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | 6,6′-dithionicotinic acid Animals Biological Transport - drug effects CPDS Ethylmaleimide - pharmacology Mersalyl - pharmacology Mitochondria, Muscle - analysis Mitochondria, Muscle - metabolism Muscle Proteins - analysis Muscle Proteins - metabolism Myocardium - ultrastructure N,N,N′,N′,-tetramethylenediamine N-ethylmeleimide NEM NIG nigericin Nigericin - pharmacology p-MB parachloromercuribenzoate Phosphates - metabolism Phosphates - pharmacology SDS sodium dodecyl sulfate Structure-Activity Relationship Swine TCA TEMED Trichloracetic acid Tris Tris (hydroxymethyl) aminomethane |
| title | Proteins dealing with N-ethylmaleimide inhibition of pig heart mitochondrial phosphate transport system |
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