Activation of the alternative complement pathway by lymphoblastoid cell lines derived from patients with Burkitt's lymphoma and infectious mononucleosis
Cultured human lymphoblastoid cell lines derived from patients with Burkitt's lymphoma or infectious mononucleosis were shown to activate the alternative pathway of complement fixation. This reaction does not require any conventional antibody directed against the cells. Although the reaction sh...
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| Veröffentlicht in: | Cellular immunology 1976-03, Vol.22 (1), p.98-109 |
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| container_title | Cellular immunology |
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| creator | Budzko, Delia B. Lachmann, P.J. McConnell, I. |
| description | Cultured human lymphoblastoid cell lines derived from patients with Burkitt's lymphoma or infectious mononucleosis were shown to activate the alternative pathway of complement fixation. This reaction does not require any conventional antibody directed against the cells. Although the reaction showed an absolute dependence on the presence of factor B it was relatively independent of the presence of factor D or of properdin. To this extent activation of the alternative pathway by lymphoblastoid cells resembles that produced by “C3-nephritic factor.” Rat and mouse complement were activated in a manner similar to human complement, but guinea pig complement was inactive. Chicken complement, unlike any of the mammalian complements tested, was able to bring about
lysis of the lymphoblastoid cell lines by the alternative pathway. |
| doi_str_mv | 10.1016/0008-8749(76)90011-3 |
| format | Article |
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lysis of the lymphoblastoid cell lines by the alternative pathway.</description><identifier>ISSN: 0008-8749</identifier><identifier>EISSN: 1090-2163</identifier><identifier>DOI: 10.1016/0008-8749(76)90011-3</identifier><identifier>PMID: 1277295</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Binding, Competitive ; Burkitt Lymphoma - immunology ; Cell Line ; Complement C3 - metabolism ; Complement System Proteins - metabolism ; Humans ; Immune Adherence Reaction ; Infectious Mononucleosis - immunology ; Lymphocytes - immunology ; Time Factors</subject><ispartof>Cellular immunology, 1976-03, Vol.22 (1), p.98-109</ispartof><rights>1976</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-7b4460378cbf141638ab0c167311f83cb2389a27f1a48bcc343f06e29f331be03</citedby><cites>FETCH-LOGICAL-c357t-7b4460378cbf141638ab0c167311f83cb2389a27f1a48bcc343f06e29f331be03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0008-8749(76)90011-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1277295$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Budzko, Delia B.</creatorcontrib><creatorcontrib>Lachmann, P.J.</creatorcontrib><creatorcontrib>McConnell, I.</creatorcontrib><title>Activation of the alternative complement pathway by lymphoblastoid cell lines derived from patients with Burkitt's lymphoma and infectious mononucleosis</title><title>Cellular immunology</title><addtitle>Cell Immunol</addtitle><description>Cultured human lymphoblastoid cell lines derived from patients with Burkitt's lymphoma or infectious mononucleosis were shown to activate the alternative pathway of complement fixation. This reaction does not require any conventional antibody directed against the cells. Although the reaction showed an absolute dependence on the presence of factor B it was relatively independent of the presence of factor D or of properdin. To this extent activation of the alternative pathway by lymphoblastoid cells resembles that produced by “C3-nephritic factor.” Rat and mouse complement were activated in a manner similar to human complement, but guinea pig complement was inactive. Chicken complement, unlike any of the mammalian complements tested, was able to bring about
lysis of the lymphoblastoid cell lines by the alternative pathway.</description><subject>Binding, Competitive</subject><subject>Burkitt Lymphoma - immunology</subject><subject>Cell Line</subject><subject>Complement C3 - metabolism</subject><subject>Complement System Proteins - metabolism</subject><subject>Humans</subject><subject>Immune Adherence Reaction</subject><subject>Infectious Mononucleosis - immunology</subject><subject>Lymphocytes - immunology</subject><subject>Time Factors</subject><issn>0008-8749</issn><issn>1090-2163</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcuOFSEQhonRjMfRN9CElZdFKzQ9Db0xGSfekknc6JoAXeSgXFqgz-S8iY8r7TnRnSuSqv8r6v8LoaeUvKaEjm8IIaITfJhe8vHVRAilHbuHdpRMpOvpyO6j3V_JQ_SolO-bZpjIBbqgPef9dLVDv65NdQdVXYo4WVz3gJWvkGMrHQCbFBYPAWLFi6r7O3XE-oj9MSz7pL0qNbkZG_Aeexeh4Blyw2Zscwob4RpZ8J2re_xuzT9crS_KGQ8KqzhjFy20FdJacEgxxdV4SMWVx-iBVb7Ak_N7ib59eP_15lN3--Xj55vr286wK147rodhJIwLoy0dmmuhNDF05IxSK5jRPROT6rmlahDaGDYwS0boJ8sY1UDYJXp-mrvk9HOFUmVwZXOkIrSlpGBMkJHRJhxOQpNTKRmsXLILKh8lJXI7iNzSllvako_yz0Eka9iz8_xVB5j_QacLtP7bUx-ayYODLItpqRmYXW7ByDm5_3_wG2BHngU</recordid><startdate>19760301</startdate><enddate>19760301</enddate><creator>Budzko, Delia B.</creator><creator>Lachmann, P.J.</creator><creator>McConnell, I.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19760301</creationdate><title>Activation of the alternative complement pathway by lymphoblastoid cell lines derived from patients with Burkitt's lymphoma and infectious mononucleosis</title><author>Budzko, Delia B. ; Lachmann, P.J. ; McConnell, I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-7b4460378cbf141638ab0c167311f83cb2389a27f1a48bcc343f06e29f331be03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>Binding, Competitive</topic><topic>Burkitt Lymphoma - immunology</topic><topic>Cell Line</topic><topic>Complement C3 - metabolism</topic><topic>Complement System Proteins - metabolism</topic><topic>Humans</topic><topic>Immune Adherence Reaction</topic><topic>Infectious Mononucleosis - immunology</topic><topic>Lymphocytes - immunology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Budzko, Delia B.</creatorcontrib><creatorcontrib>Lachmann, P.J.</creatorcontrib><creatorcontrib>McConnell, I.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cellular immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Budzko, Delia B.</au><au>Lachmann, P.J.</au><au>McConnell, I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activation of the alternative complement pathway by lymphoblastoid cell lines derived from patients with Burkitt's lymphoma and infectious mononucleosis</atitle><jtitle>Cellular immunology</jtitle><addtitle>Cell Immunol</addtitle><date>1976-03-01</date><risdate>1976</risdate><volume>22</volume><issue>1</issue><spage>98</spage><epage>109</epage><pages>98-109</pages><issn>0008-8749</issn><eissn>1090-2163</eissn><abstract>Cultured human lymphoblastoid cell lines derived from patients with Burkitt's lymphoma or infectious mononucleosis were shown to activate the alternative pathway of complement fixation. This reaction does not require any conventional antibody directed against the cells. Although the reaction showed an absolute dependence on the presence of factor B it was relatively independent of the presence of factor D or of properdin. To this extent activation of the alternative pathway by lymphoblastoid cells resembles that produced by “C3-nephritic factor.” Rat and mouse complement were activated in a manner similar to human complement, but guinea pig complement was inactive. Chicken complement, unlike any of the mammalian complements tested, was able to bring about
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| ispartof | Cellular immunology, 1976-03, Vol.22 (1), p.98-109 |
| issn | 0008-8749 1090-2163 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Binding, Competitive Burkitt Lymphoma - immunology Cell Line Complement C3 - metabolism Complement System Proteins - metabolism Humans Immune Adherence Reaction Infectious Mononucleosis - immunology Lymphocytes - immunology Time Factors |
| title | Activation of the alternative complement pathway by lymphoblastoid cell lines derived from patients with Burkitt's lymphoma and infectious mononucleosis |
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