Binding of Salicylate and Sulfathiazole by Whole Blood Constituents
The binding of salicylic acid and sulfathiazole to bovine whole blood, plasma proteins, and purified albumin fraction was investigated using a dynamic dialysis system. The binding profiles for salicylic acid were quite similar in bovine plasma and 4% bovine serum albumin. In contrast, the binding of...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1976-01, Vol.65 (1), p.33-37 |
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| container_title | Journal of pharmaceutical sciences |
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| creator | Cruze, Charles A. Meyer, Marvin C. |
| description | The binding of salicylic acid and sulfathiazole to bovine whole blood, plasma proteins, and purified albumin fraction was investigated using a dynamic dialysis system. The binding profiles for salicylic acid were quite similar in bovine plasma and 4% bovine serum albumin. In contrast, the binding of sulfathiazole was significantly greater in the plasma than in solutions of fraction V bovine serum albumin. Data from dynamic dialysis binding studies of the compounds, conducted in whole blood and suspended erythrocyte systems, did not lend themselves to analysis by classical methods. Hemolysis and alteration in the nature of the protein binding sites during the binding studies were shown to be factors that could explain the unusual binding observed in the whole blood system. |
| doi_str_mv | 10.1002/jps.2600650105 |
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The binding profiles for salicylic acid were quite similar in bovine plasma and 4% bovine serum albumin. In contrast, the binding of sulfathiazole was significantly greater in the plasma than in solutions of fraction V bovine serum albumin. Data from dynamic dialysis binding studies of the compounds, conducted in whole blood and suspended erythrocyte systems, did not lend themselves to analysis by classical methods. Hemolysis and alteration in the nature of the protein binding sites during the binding studies were shown to be factors that could explain the unusual binding observed in the whole blood system.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600650105</identifier><identifier>PMID: 1255431</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Albumin-purified fractions ; Albumin—purified fractions, compared to bovine whole blood and plasma protein binding of salicylate and sulfathiazole ; and purified albumin fractions compared ; Animals ; Binding Sites - drug effects ; Binding, Competitive - drug effects ; Binding-salicylate and sulfathiazole to bovine whole blood ; Binding—salicylate and sulfathiazole to bovine whole blood, plasma proteins, and purified albumin fractions compared ; Cattle ; compared to bovine whole blood and plasma protein binding of salicylate and sulfathiazole ; Erythrocytes - metabolism ; Hemolysis ; In Vitro Techniques ; Plasma - metabolism ; plasma proteins ; Plasma proteins-compared to bovine whole blood and purified albumin fraction binding of salicylate and sulfathiazole ; Protein Binding ; Salicylate-binding to bovine whole blood ; Salicylates - blood ; Salicylate—binding to bovine whole blood, plasma proteins, and purified albumin fractions compared ; Serum Albumin, Bovine - metabolism ; Sulfathiazole-binding to bovine whole blood ; Sulfathiazoles - blood ; Sulfathiazole—binding to bovine whole blood, plasma proteins, and purified albumin fractions compared ; Time Factors</subject><ispartof>Journal of pharmaceutical sciences, 1976-01, Vol.65 (1), p.33-37</ispartof><rights>1976 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1976 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4275-b289d750c8234e91d13e6a5af4c0dea010922f9255b73bd95d190b3da3ca36703</citedby><cites>FETCH-LOGICAL-c4275-b289d750c8234e91d13e6a5af4c0dea010922f9255b73bd95d190b3da3ca36703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600650105$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600650105$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1255431$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cruze, Charles A.</creatorcontrib><creatorcontrib>Meyer, Marvin C.</creatorcontrib><title>Binding of Salicylate and Sulfathiazole by Whole Blood Constituents</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>The binding of salicylic acid and sulfathiazole to bovine whole blood, plasma proteins, and purified albumin fraction was investigated using a dynamic dialysis system. The binding profiles for salicylic acid were quite similar in bovine plasma and 4% bovine serum albumin. In contrast, the binding of sulfathiazole was significantly greater in the plasma than in solutions of fraction V bovine serum albumin. Data from dynamic dialysis binding studies of the compounds, conducted in whole blood and suspended erythrocyte systems, did not lend themselves to analysis by classical methods. Hemolysis and alteration in the nature of the protein binding sites during the binding studies were shown to be factors that could explain the unusual binding observed in the whole blood system.</description><subject>Albumin-purified fractions</subject><subject>Albumin—purified fractions, compared to bovine whole blood and plasma protein binding of salicylate and sulfathiazole</subject><subject>and purified albumin fractions compared</subject><subject>Animals</subject><subject>Binding Sites - drug effects</subject><subject>Binding, Competitive - drug effects</subject><subject>Binding-salicylate and sulfathiazole to bovine whole blood</subject><subject>Binding—salicylate and sulfathiazole to bovine whole blood, plasma proteins, and purified albumin fractions compared</subject><subject>Cattle</subject><subject>compared to bovine whole blood and plasma protein binding of salicylate and sulfathiazole</subject><subject>Erythrocytes - metabolism</subject><subject>Hemolysis</subject><subject>In Vitro Techniques</subject><subject>Plasma - metabolism</subject><subject>plasma proteins</subject><subject>Plasma proteins-compared to bovine whole blood and purified albumin fraction binding of salicylate and sulfathiazole</subject><subject>Protein Binding</subject><subject>Salicylate-binding to bovine whole blood</subject><subject>Salicylates - blood</subject><subject>Salicylate—binding to bovine whole blood, plasma proteins, and purified albumin fractions compared</subject><subject>Serum Albumin, Bovine - metabolism</subject><subject>Sulfathiazole-binding to bovine whole blood</subject><subject>Sulfathiazoles - blood</subject><subject>Sulfathiazole—binding to bovine whole blood, plasma proteins, and purified albumin fractions compared</subject><subject>Time Factors</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDtPwzAURi0EglJY2ZAysaX4ESfNCBUUKl6ioI6WY9-AwY1LnADl12OUCsSAmGzpnu_TvQehPYIHBGN6-LTwA5pinHJMMF9DPcIpjlNMsnXUCwCNGU_yLbTt_RMOGOZ8E20SynnCSA-Njk2lTfUQuTKaSmvU0soGIlnpaNraUjaPRn44C1GxjGaPX59j65yORq7yjWlaqBq_gzZKaT3srt4-uj89uRudxRfX4_PR0UWsEprxuKDDXGccqyFlCeREEwap5LJMFNYgw_o5pWUeNisyVuica5LjgmnJlGRphlkfHXS9i9q9tOAbMTdegbWyAtd6MWSMk4TRAA46UNXO-xpKsajNXNZLQbD4siaCNfFjLQT2V81tMQf9g3eawjzv5m_GwvKfNjG5mf7qjrus8Q28f2dl_SzSjGVczK7G4pKdzSaTWy5Y4IcdD0Hlq4FaeGWgUqBNDaoR2pm_zvgEoU2Zbw</recordid><startdate>197601</startdate><enddate>197601</enddate><creator>Cruze, Charles A.</creator><creator>Meyer, Marvin C.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197601</creationdate><title>Binding of Salicylate and Sulfathiazole by Whole Blood Constituents</title><author>Cruze, Charles A. ; Meyer, Marvin C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4275-b289d750c8234e91d13e6a5af4c0dea010922f9255b73bd95d190b3da3ca36703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>Albumin-purified fractions</topic><topic>Albumin—purified fractions, compared to bovine whole blood and plasma protein binding of salicylate and sulfathiazole</topic><topic>and purified albumin fractions compared</topic><topic>Animals</topic><topic>Binding Sites - drug effects</topic><topic>Binding, Competitive - drug effects</topic><topic>Binding-salicylate and sulfathiazole to bovine whole blood</topic><topic>Binding—salicylate and sulfathiazole to bovine whole blood, plasma proteins, and purified albumin fractions compared</topic><topic>Cattle</topic><topic>compared to bovine whole blood and plasma protein binding of salicylate and sulfathiazole</topic><topic>Erythrocytes - metabolism</topic><topic>Hemolysis</topic><topic>In Vitro Techniques</topic><topic>Plasma - metabolism</topic><topic>plasma proteins</topic><topic>Plasma proteins-compared to bovine whole blood and purified albumin fraction binding of salicylate and sulfathiazole</topic><topic>Protein Binding</topic><topic>Salicylate-binding to bovine whole blood</topic><topic>Salicylates - blood</topic><topic>Salicylate—binding to bovine whole blood, plasma proteins, and purified albumin fractions compared</topic><topic>Serum Albumin, Bovine - metabolism</topic><topic>Sulfathiazole-binding to bovine whole blood</topic><topic>Sulfathiazoles - blood</topic><topic>Sulfathiazole—binding to bovine whole blood, plasma proteins, and purified albumin fractions compared</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cruze, Charles A.</creatorcontrib><creatorcontrib>Meyer, Marvin C.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cruze, Charles A.</au><au>Meyer, Marvin C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Binding of Salicylate and Sulfathiazole by Whole Blood Constituents</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1976-01</date><risdate>1976</risdate><volume>65</volume><issue>1</issue><spage>33</spage><epage>37</epage><pages>33-37</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>The binding of salicylic acid and sulfathiazole to bovine whole blood, plasma proteins, and purified albumin fraction was investigated using a dynamic dialysis system. The binding profiles for salicylic acid were quite similar in bovine plasma and 4% bovine serum albumin. In contrast, the binding of sulfathiazole was significantly greater in the plasma than in solutions of fraction V bovine serum albumin. Data from dynamic dialysis binding studies of the compounds, conducted in whole blood and suspended erythrocyte systems, did not lend themselves to analysis by classical methods. Hemolysis and alteration in the nature of the protein binding sites during the binding studies were shown to be factors that could explain the unusual binding observed in the whole blood system.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>1255431</pmid><doi>10.1002/jps.2600650105</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of pharmaceutical sciences, 1976-01, Vol.65 (1), p.33-37 |
| issn | 0022-3549 1520-6017 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Albumin-purified fractions Albumin—purified fractions, compared to bovine whole blood and plasma protein binding of salicylate and sulfathiazole and purified albumin fractions compared Animals Binding Sites - drug effects Binding, Competitive - drug effects Binding-salicylate and sulfathiazole to bovine whole blood Binding—salicylate and sulfathiazole to bovine whole blood, plasma proteins, and purified albumin fractions compared Cattle compared to bovine whole blood and plasma protein binding of salicylate and sulfathiazole Erythrocytes - metabolism Hemolysis In Vitro Techniques Plasma - metabolism plasma proteins Plasma proteins-compared to bovine whole blood and purified albumin fraction binding of salicylate and sulfathiazole Protein Binding Salicylate-binding to bovine whole blood Salicylates - blood Salicylate—binding to bovine whole blood, plasma proteins, and purified albumin fractions compared Serum Albumin, Bovine - metabolism Sulfathiazole-binding to bovine whole blood Sulfathiazoles - blood Sulfathiazole—binding to bovine whole blood, plasma proteins, and purified albumin fractions compared Time Factors |
| title | Binding of Salicylate and Sulfathiazole by Whole Blood Constituents |
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