Synthesis of 5-hydroxy-1-((5-(p-nitrophenyl)furfurylidene)-amino) hydantoin, a metabolite of dantrolene

Synthesis of 5-hydroxy-1-((5-(p-nitrophenyl)furfurylidene)-amino) hydantoin, a metabolite of dantrolene

The synthesis and structural elucidation of 5-hydroxyl-1-[[5-(p-nitrophenyl)furfurylidene]amino]hydantoin, a compound proposed as a metabolite of dantrolene sodium, are reported. In addition, a chromatographic comparison of the biological and synthesized materials is made.

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Veröffentlicht in:Journal of pharmaceutical sciences 1976-01, Vol.65 (1), p.UNKNOWN-UNKNOWN
Hauptverfasser: White, R L, Schwan, T J
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Sprache:eng
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Dantrolene - analogs & derivatives
Dantrolene - chemical synthesis
Dantrolene - metabolism
Hydantoins - analogs & derivatives
Methods
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container_title Journal of pharmaceutical sciences
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creator White, R L
Schwan, T J
description The synthesis and structural elucidation of 5-hydroxyl-1-[[5-(p-nitrophenyl)furfurylidene]amino]hydantoin, a compound proposed as a metabolite of dantrolene sodium, are reported. In addition, a chromatographic comparison of the biological and synthesized materials is made.
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source MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection
subjects Dantrolene - analogs & derivatives
Dantrolene - chemical synthesis
Dantrolene - metabolism
Hydantoins - analogs & derivatives
Methods
title Synthesis of 5-hydroxy-1-((5-(p-nitrophenyl)furfurylidene)-amino) hydantoin, a metabolite of dantrolene
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