Physicochemical and pharmacological studies of some 8-substituted decahydroisoquinolines

Several compounds of a diastereoisomeric series of 8-substituted 2-methyldecahydroisoquinolines have been found to be equipotent or more potent than quinidine in prolonging the refractory period of isolated guinea pig atria. The effects of selected compounds on the intracellularly recorded transmemb...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 1976-03, Vol.19 (3), p.385-391
Hauptverfasser:	Mathison, Ian W., Morgan, Phillip H., Wojciechowski, Norbert J., Bandura, Jack P., Wennemark, James R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Action Potentials - drug effects Animals Cell Membrane - metabolism Chemical Phenomena Chemistry, Physical Dogs Electric Stimulation Guinea Pigs Heart Atria - drug effects Heart Rate - drug effects Humans In Vitro Techniques Isoquinolines - metabolism Isoquinolines - pharmacology Kinetics Membrane Potentials - drug effects Purkinje Fibers - drug effects Purkinje Fibers - physiology Refractory Period, Electrophysiological - drug effects Stereoisomerism Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!