MICROBIAL PRODUCTION OF AMPHOTERICIN B-3H AND THE SYNTHESIS OF ITS SODIUM DESOXYCHOLATE (CARBOXYL-14C) COMPLEX AND METHYL-14C-ESTER

Amphotericin B-3H with a specific radioactivity in excess of 4 μCi/mg was produced by fermentation of Streptomyces nodosus IMRU 3694 in a complex medium, using acetate-3H as a precursor. The medium employed gave a production yield of 2.5-3.5 mg/ml of amphotericin B. The most efficient incorporation...

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Veröffentlicht in:	Journal of antibiotics 1976, Vol.29(4), pp.438-443
Hauptverfasser:	MONJI, NOBUO, MECHLINSKI, WITOLD, SCHAFFNER, CARL P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - metabolism Alcohols - pharmacology Amphotericin B - analogs & derivatives Amphotericin B - isolation & purification Amphotericin B - metabolism Deoxycholic Acid - chemical synthesis Depression, Chemical Esters - chemical synthesis Fermentation Streptomyces - drug effects Streptomyces - metabolism
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