The adrenergic antagonism of amiodarone

Inhibition by amiodarone and propranolol of the chronotropic effect of isoproterenol on spontaneously beating rabbit right atria has been studied in vitro. Propranolol behaved like a typical competitive β 1-adrenoceptor antagonist with a p A 2 value of 8.33. Amiodarone acted as a non-competitive inh...

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Veröffentlicht in:	Biochemical pharmacology 1976-01, Vol.25 (2), p.131-134
Hauptverfasser:	Polster, P., Broekhuysen, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amiodarone - pharmacology Animals Aorta, Thoracic - drug effects Aorta, Thoracic - physiology Atrial Function Benzofurans - pharmacology Dose-Response Relationship, Drug Female Heart Atria - drug effects Heart Rate - drug effects Isoproterenol - pharmacology Male Norepinephrine - pharmacology Propranolol - pharmacology Rabbits Receptors, Adrenergic Stimulation, Chemical
Online-Zugang:	Volltext
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